A Neural Network Model for Cursive Script Production

This article describes a neural network model, called the VITEWRITE model, for generating handwriting movements. The model consists of a sequential controller, or motor program, that interacts with a trajectory generator to move a. hand with redundant degrees of freedom. The neural trajectory generator is the Vector Integration to Endpoint (VITE) model for synchronous variable-speed control of multijoint movements. VITE properties enable a simple control strategy to generate complex handwritten script if the hand model contains redundant degrees of freedom. The proposed controller launches transient directional commands to independent hand synergies at times when the hand begins to move, or when a velocity peak in a given synergy is achieved. The VITE model translates these temporally disjoint synergy commands into smooth curvilinear trajectories among temporally overlapping synergetic movements. The separate "score" of onset times used in most prior models is hereby replaced by a self-scaling activity-released "motor program" that uses few memory resources, enables each synergy to exhibit a unimodal velocity profile during any stroke, generates letters that are invariant under speed and size rescaling, and enables effortless. connection of letter shapes into words. Speed and size rescaling are achieved by scalar GO and GRO signals that express computationally simple volitional commands. Psychophysical data concerning band movements, such as the isochrony principle, asymmetric velocity profiles, and the two-thirds power law relating movement curvature and velocity arise as emergent properties of model interactions.National Science Foundation (IRI 90-24877, IRI 87-16960); Office of Naval Research (N00014-92-J-1309); Air Force Office of Scientific Research (F49620-92-J-0499); Defense Advanced Research Projects Agency (90-0083

Neural Models of Temporally Organized Behaviors: Handwriting Production and Working Memory

Advanced Research Projects Agency (ONR N00014-92-J-4015); Office of Naval Research (N00014-91-J-4100, N00014-92-J-1309

Formal verification of safety properties in timed circuits

The incorporation of timing makes circuit verification computationally expensive. This paper proposes a new approach for the verification of timed circuits. Rather than calculating the exact timed stare space, a conservative overestimation that fulfills the property under verification is derived. Timing analysis with absolute delays is efficiently performed at the level of event structures and transformed into a set of relative timing constraints. With this approach, conventional symbolic techniques for reachability analysis can be efficiently combined with timing analysis. Moreover the set of timing constraints used to prove the correctness of the circuit can also be reported for backannotation purposes. Some preliminary results obtained by a naive implementation of the approach show that systems with more than 10/sup 6/ untimed states can be verified.Peer ReviewedPostprint (published version

A Vector-Integration-to-Endpoint Model for Performance of Viapoint Movements

Viapoint (VP) movements are movements to a desired point that are constrained to pass through an intermediate point. Studies have shown that VP movements possess properties, such as smooth curvature around the VP, that are not explicable by treating VP movements as strict concatenations of simpler point-to-point (PTP) movements. Such properties have led some theorists to propose whole-trajectory optimization models, which imply that the entire trajectory is pre-computed before movement initiation. This paper reports new experiments conducted to systematically compare VP with PTP trajectories. Analyses revealed a statistically significant early directional deviation in VP movements but no associated curvature change. An explanation of this effect is offered by extending the Vector-Integration-To-Endpoint (VITE) model (Bullock and Grossberg, 1988), which postulates that voluntary movement trajectories emerge as internal gating signals control the integration of continuously computed vector commands based on the evolving, perceptible difference between desired and actual position variables. The model explains the observed trajectories of VP and PTP movements as emergent properties of a dynamical system that does not precompute entire trajectories before movement initiation. The new model includes a working memory and a stage sensitive to time-to-contact information. These cooperate to control serial performance. The structural and functional relationships proposed in the model are consistent with available data on forebrain physiology and anatomy.Office of Naval Research (N00014-92-J-1309, N00014-93-1-1364, N0014-95-1-0409

Neural Dynamics of Autistic Behaviors: Cognitive, Emotional, and Timing Substrates

What brain mechanisms underlie autism and how do they give rise to autistic behavioral symptoms? This article describes a neural model, called the iSTART model, which proposes how cognitive, emotional, timing, and motor processes may interact together to create and perpetuate autistic symptoms. These model processes were originally developed to explain data concerning how the brain controls normal behaviors. The iSTART model shows how autistic behavioral symptoms may arise from prescribed breakdowns in these brain processes.Air Force Office of Scientific Research (F49620-01-1-0397); Office of Naval Research (N00014-01-1-0624

Specifications and programs for computer software validation

Three software products developed during the study are reported and include: (1) FORTRAN Automatic Code Evaluation System, (2) the Specification Language System, and (3) the Array Index Validation System

Doctor of Philosophy

dissertationThe design of integrated circuit (IC) requires an exhaustive verification and a thorough test mechanism to ensure the functionality and robustness of the circuit. This dissertation employs the theory of relative timing that has the advantage of enabling designers to create designs that have significant power and performance over traditional clocked designs. Research has been carried out to enable the relative timing approach to be supported by commercial electronic design automation (EDA) tools. This allows asynchronous and sequential designs to be designed using commercial cad tools. However, two very significant holes in the flow exist: the lack of support for timing verification and manufacturing test. Relative timing (RT) utilizes circuit delay to enforce and measure event sequencing on circuit design. Asynchronous circuits can optimize power-performance product by adjusting the circuit timing. A thorough analysis on the timing characteristic of each and every timing path is required to ensure the robustness and correctness of RT designs. All timing paths have to conform to the circuit timing constraints. This dissertation addresses back-end design robustness by validating full cyclical path timing verification with static timing analysis and implementing design for testability (DFT). Circuit reliability and correctness are necessary aspects for the technology to become commercially ready. In this study, scan-chain, a commercial DFT implementation, is applied to burst-mode RT designs. In addition, a novel testing approach is developed along with scan-chain to over achieve 90% fault coverage on two fault models: stuck-at fault model and delay fault model. This work evaluates the cost of DFT and its coverage trade-off then determines the best implementation. Designs such as a 64-point fast Fourier transform (FFT) design, an I2C design, and a mixed-signal design are built to demonstrate power, area, performance advantages of the relative timing methodology and are used as a platform for developing the backend robustness. Results are verified by performing post-silicon timing validation and test. This work strengthens overall relative timed circuit flow, reliability, and testability

Petri nets for systems and synthetic biology

We give a description of a Petri net-based framework for modelling and analysing biochemical pathways, which uni¯es the qualita- tive, stochastic and continuous paradigms. Each perspective adds its con- tribution to the understanding of the system, thus the three approaches do not compete, but complement each other. We illustrate our approach by applying it to an extended model of the three stage cascade, which forms the core of the ERK signal transduction pathway. Consequently our focus is on transient behaviour analysis. We demonstrate how quali- tative descriptions are abstractions over stochastic or continuous descrip- tions, and show that the stochastic and continuous models approximate each other. Although our framework is based on Petri nets, it can be applied more widely to other formalisms which are used to model and analyse biochemical networks