153 research outputs found
Swarm Learning for decentralized and confidential clinical machine learning
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine1,2. Patients with leukaemia can be identified using machine learning on the basis of their blood transcriptomes3. However, there is an increasing divide between what is technically possible and what is allowed, because of privacy legislation4,5. Here, to facilitate the integration of any medical data from any data owner worldwide without violating privacy laws, we introduce Swarm Learning—a decentralized machine-learning approach that unites edge computing, blockchain-based peer-to-peer networking and coordination while maintaining confidentiality without the need for a central coordinator, thereby going beyond federated learning. To illustrate the feasibility of using Swarm Learning to develop disease classifiers using distributed data, we chose four use cases of heterogeneous diseases (COVID-19, tuberculosis, leukaemia and lung pathologies). With more than 16,400 blood transcriptomes derived from 127 clinical studies with non-uniform distributions of cases and controls and substantial study biases, as well as more than 95,000 chest X-ray images, we show that Swarm Learning classifiers outperform those developed at individual sites. In addition, Swarm Learning completely fulfils local confidentiality regulations by design. We believe that this approach will notably accelerate the introduction of precision medicine
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Artificial Immune Systems - Models, algorithms and applications
Copyright © 2010 Academic Research Publishing Agency.This article has been made available through the Brunel Open Access Publishing Fund.Artificial Immune Systems (AIS) are computational paradigms that belong to the computational intelligence family and are inspired by the biological immune system. During the past decade, they have attracted a lot of interest from researchers aiming to develop immune-based models and techniques to solve complex computational or engineering problems. This work presents a survey of existing AIS models and algorithms with a focus on the last five years.This article is available through the Brunel Open Access Publishing Fun
Guided Deep Reinforcement Learning for Swarm Systems
In this paper, we investigate how to learn to control a group of cooperative
agents with limited sensing capabilities such as robot swarms. The agents have
only very basic sensor capabilities, yet in a group they can accomplish
sophisticated tasks, such as distributed assembly or search and rescue tasks.
Learning a policy for a group of agents is difficult due to distributed partial
observability of the state. Here, we follow a guided approach where a critic
has central access to the global state during learning, which simplifies the
policy evaluation problem from a reinforcement learning point of view. For
example, we can get the positions of all robots of the swarm using a camera
image of a scene. This camera image is only available to the critic and not to
the control policies of the robots. We follow an actor-critic approach, where
the actors base their decisions only on locally sensed information. In
contrast, the critic is learned based on the true global state. Our algorithm
uses deep reinforcement learning to approximate both the Q-function and the
policy. The performance of the algorithm is evaluated on two tasks with simple
simulated 2D agents: 1) finding and maintaining a certain distance to each
others and 2) locating a target.Comment: 15 pages, 8 figures, accepted at the AAMAS 2017 Autonomous Robots and
Multirobot Systems (ARMS) Worksho
Direct prediction of genetic aberrations from pathology images in gastric cancer with swarm learning.
BACKGROUND
Computational pathology uses deep learning (DL) to extract biomarkers from routine pathology slides. Large multicentric datasets improve performance, but such datasets are scarce for gastric cancer. This limitation could be overcome by Swarm Learning (SL).
METHODS
Here, we report the results of a multicentric retrospective study of SL for prediction of molecular biomarkers in gastric cancer. We collected tissue samples with known microsatellite instability (MSI) and Epstein-Barr Virus (EBV) status from four patient cohorts from Switzerland, Germany, the UK and the USA, storing each dataset on a physically separate computer.
RESULTS
On an external validation cohort, the SL-based classifier reached an area under the receiver operating curve (AUROC) of 0.8092 (± 0.0132) for MSI prediction and 0.8372 (± 0.0179) for EBV prediction. The centralized model, which was trained on all datasets on a single computer, reached a similar performance.
CONCLUSIONS
Our findings demonstrate the feasibility of SL-based molecular biomarkers in gastric cancer. In the future, SL could be used for collaborative training and, thus, improve the performance of these biomarkers. This may ultimately result in clinical-grade performance and generalizability
Swarm Learning for decentralized and confidential clinical machine learning
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine. Patients with leukaemia can be identified using machine learning on the basis of their blood transcriptomes. However, there is an increasing divide between what is technically possible and what is allowed, because of privacy legislation. Here, to facilitate the integration of any medical data from any data owner worldwide without violating privacy laws, we introduce Swarm Learning—a decentralized machine-learning approach that unites edge computing, blockchain-based peer-to-peer networking and coordination while maintaining confidentiality without the need for a central coordinator, thereby going beyond federated learning. To illustrate the feasibility of using Swarm Learning to develop disease classifiers using distributed data, we chose four use cases of heterogeneous diseases (COVID-19, tuberculosis, leukaemia and lung pathologies). With more than 16,400 blood transcriptomes derived from 127 clinical studies with non-uniform distributions of cases and controls and substantial study biases, as well as more than 95,000 chest X-ray images, we show that Swarm Learning classifiers outperform those developed at individual sites. In addition, Swarm Learning completely fulfils local confidentiality regulations by design. We believe that this approach will notably accelerate the introduction of precision medicine
A Design Toolbox for the Development of Collaborative Distributed Machine Learning Systems
To leverage training data for the sufficient training of ML models from multiple parties in a confidentiality-preserving way, various collaborative distributed machine learning (CDML) system designs have been developed, for example, to perform assisted learning, federated learning, and split learning. CDML system designs show different traits, for example, high agent autonomy, machine learning (ML) model confidentiality, and fault tolerance. Facing a wide variety of CDML system designs with different traits, it is difficult for developers to design CDML systems with traits that match use case requirements in a targeted way. However, inappropriate CDML system designs may result in CDML systems failing their envisioned purposes. We developed a CDML design toolbox that can guide the development of CDML systems. Based on the CDML design toolbox, we present CDML system archetypes with distinct key traits that can support the design of CDML systems to meet use case requirements
Unrolled Graph Learning for Multi-Agent Collaboration
Multi-agent learning has gained increasing attention to tackle distributed
machine learning scenarios under constrictions of data exchanging. However,
existing multi-agent learning models usually consider data fusion under fixed
and compulsory collaborative relations among agents, which is not as flexible
and autonomous as human collaboration. To fill this gap, we propose a
distributed multi-agent learning model inspired by human collaboration, in
which the agents can autonomously detect suitable collaborators and refer to
collaborators' model for better performance. To implement such adaptive
collaboration, we use a collaboration graph to indicate the pairwise
collaborative relation. The collaboration graph can be obtained by graph
learning techniques based on model similarity between different agents. Since
model similarity can not be formulated by a fixed graphical optimization, we
design a graph learning network by unrolling, which can learn underlying
similar features among potential collaborators. By testing on both regression
and classification tasks, we validate that our proposed collaboration model can
figure out accurate collaborative relationship and greatly improve agents'
learning performance
MentalHealthAI: Utilizing Personal Health Device Data to Optimize Psychiatry Treatment
Mental health disorders remain a significant challenge in modern healthcare,
with diagnosis and treatment often relying on subjective patient descriptions
and past medical history. To address this issue, we propose a personalized
mental health tracking and mood prediction system that utilizes patient
physiological data collected through personal health devices. Our system
leverages a decentralized learning mechanism that combines transfer and
federated machine learning concepts using smart contracts, allowing data to
remain on users' devices and enabling effective tracking of mental health
conditions for psychiatric treatment and management in a privacy-aware and
accountable manner. We evaluate our model using a popular mental health dataset
that demonstrates promising results. By utilizing connected health systems and
machine learning models, our approach offers a novel solution to the challenge
of providing psychiatrists with further insight into their patients' mental
health outside of traditional office visits.Comment: Accepted at AMIA 2023 Annual Symposiu
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