Surface enhanced Raman spectroscopy on single mode nanophotonic-plasmonic waveguides

We analyze the generation of Surface Enhanced Raman Spectroscopy signals from integrated bowtie antennas, excited and collected by a single mode silicon nitride waveguide, and discuss strategies to enhance the Signal-to-Noise Ratio

Gold nanoparticle coated silicon nitride chips for intracellular surface-enhanced raman spectroscopy

Using surface-enhanced Raman spectroscopy on gold-nanoparticle-decorated silicon nitride chips, we monitor the release of dextran-rhodamin molecules from capsules inside living cells. This demonstrates the feasibility of using photonic chips for intracellular sensing at visible wavelengths

Surface-enhanced Raman spectroscopy: nonlocal limitations

Giant field enhancement and field singularities are a natural consequence of the commonly employed local-response framework. We show that a more general nonlocal treatment of the plasmonic response leads to new and possibly fundamental limitations on field enhancement with important consequences for our understanding of surface-enhanced Raman spectroscopy (SERS). The intrinsic length scale of the electron gas serves to smear out assumed field singularities, leaving the SERS enhancement factor finite, even for geometries with infinitely sharp features. For silver nanogroove structures, mimicked by periodic arrays of half-cylinders (up to 120 nm in radius), we find no enhancement factors exceeding 10 orders of magnitude (1010).</p

Surface enhanced Raman spectroscopy of neurotransmitters

The surface‐enhanced Raman spectra (SERS) of neurotransmitters in biological matrices and synthetic solutions are described. The effects of protein adsorption on cathecholamine SERS intensity are discussed. Techniques for obtaining dopamine SERS spectra in cerebrospinal fluid and rat brain dialysate are demonstrated. Preliminary SERS of histamine and tel‐methylhistamine are presented.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87497/2/707_1.pd

Gold nanodome-patterned microchips for intracellular surface-enhanced Raman spectroscopy

While top-down substrates for surface-enhanced Raman spectroscopy (SERS) offer outstanding control and reproducibility of the gold nanopatterns and their related localized surface plasmon resonance, intracellular SERS experiments heavily rely on gold nanoparticles. These nanoparticles often result in varying and uncontrollable enhancement factors. Here we demonstrate the use of top-down gold-nanostructured microchips for intracellular sensing. We develop a tunable and reproducible fabrication scheme for these microchips. Furthermore we observe the intracellular uptake of these structures, and find no immediate influence on cell viability. Finally, we perform a proof-of-concept intracellular SERS experiment by the label-free detection of extraneous molecules. By bringing top-down SERS substrates to the intracellular world, we set an important step towards time-dependent and quantitative intracellular SERS