Impaired extraction of speech rhythm from temporal modulation patterns in speech in developmental dyslexia

Dyslexia is associated with impaired neural representation of the sound structure of words (phonology). The “phonological deficit” in dyslexia may arise in part from impaired speech rhythm perception, thought to depend on neural oscillatory phase-locking to slow amplitude modulation (AM) patterns in the speech envelope. Speech contains AM patterns at multiple temporal rates, and these different AM rates are associated with phonological units of different grain sizes, e.g., related to stress, syllables or phonemes. Here, we assess the ability of adults with dyslexia to use speech AMs to identify rhythm patterns (RPs). We study 3 important temporal rates: “Stress” (~2 Hz), “Syllable” (~4 Hz) and “Sub-beat” (reduced syllables, ~14 Hz). 21 dyslexics and 21 controls listened to nursery rhyme sentences that had been tone-vocoded using either single AM rates from the speech envelope (Stress only, Syllable only, Sub-beat only) or pairs of AM rates (Stress + Syllable, Syllable + Sub-beat). They were asked to use the acoustic rhythm of the stimulus to identity the original nursery rhyme sentence. The data showed that dyslexics were significantly poorer at detecting rhythm compared to controls when they had to utilize multi-rate temporal information from pairs of AMs (Stress + Syllable or Syllable + Sub-beat). These data suggest that dyslexia is associated with a reduced ability to utilize AMs <20 Hz for rhythm recognition. This perceptual deficit in utilizing AM patterns in speech could be underpinned by less efficient neuronal phase alignment and cross-frequency neuronal oscillatory synchronization in dyslexia. Dyslexics' perceptual difficulties in capturing the full spectro-temporal complexity of speech over multiple timescales could contribute to the development of impaired phonological representations for words, the cognitive hallmark of dyslexia across languages

The Acoustic Change Complex for Measuring Speech Perceptual Performance in Normal Hearing Listeners in Noise, Cochlear Implant Users, and Second Language Listeners

A series of experiments recorded the acoustic change complex (ACC) to a broad range of speech stimuli. The ACC is an electrophysiological response to an acoustic change within an on-going stimulus. Recordings were obtained from normal hearing (NH) listeners in noise, cochlear implanted (CI) listeners, and second language listeners. Chapter 2 presented a mixture of transitions between four vowels and four fricatives in quiet and at three noise levels to NH listeners. We investigated how the ACC was affected by noise, and how the ACC relates to individuals’ behavioural speech-in-noise ability. Chapter 3 details a CI study using the same fricative and vowel stimuli but in quiet only. The ACC was measured and again compared to behavioural speech perception performance. Participants’ neural entrainment to continuous speech was also measured, and compared to their speech perception performance and ACC responses. Chapter 4 details an ACC study using a mixture of transitions between eight voiceless fricatives presented to native English, Finnish and Polish speakers. The ACC magnitude was used to create similarity matrices that were analysed by non-metric MDS and an acoustic analysis of the fricative stimuli was performed. The ACC and its relationship to the spectra of the stimuli were used to investigate cross language differences between the groups. Overall, results suggest that the ACC is not merely a measure of general auditory detection as it is often described, but rather it is a measure at the border between auditory and linguistic processing in the auditory cortex. Furthermore, the results indicate that the ACC has potential for further use in research in a variety of listener populations, as well as potential clinical benefits

Representation of statistical sound properties in human auditory cortex

The work carried out in this doctoral thesis investigated the representation of statistical sound properties in human auditory cortex. It addressed four key aspects in auditory neuroscience: the representation of different analysis time windows in auditory cortex; mechanisms for the analysis and segregation of auditory objects; information-theoretic constraints on pitch sequence processing; and the analysis of local and global pitch patterns. The majority of the studies employed a parametric design in which the statistical properties of a single acoustic parameter were altered along a continuum, while keeping other sound properties fixed. The thesis is divided into four parts. Part I (Chapter 1) examines principles of anatomical and functional organisation that constrain the problems addressed. Part II (Chapter 2) introduces approaches to digital stimulus design, principles of functional magnetic resonance imaging (fMRI), and the analysis of fMRI data. Part III (Chapters 3-6) reports five experimental studies. Study 1 controlled the spectrotemporal correlation in complex acoustic spectra and showed that activity in auditory association cortex increases as a function of spectrotemporal correlation. Study 2 demonstrated a functional hierarchy of the representation of auditory object boundaries and object salience. Studies 3 and 4 investigated cortical mechanisms for encoding entropy in pitch sequences and showed that the planum temporale acts as a computational hub, requiring more computational resources for sequences with high entropy than for those with high redundancy. Study 5 provided evidence for a hierarchical organisation of local and global pitch pattern processing in neurologically normal participants. Finally, Part IV (Chapter 7) concludes with a general discussion of the results and future perspectives

Audiovisual speech perception in cochlear implant patients

Hearing with a cochlear implant (CI) is very different compared to a normal-hearing (NH) experience, as the CI can only provide limited auditory input. Nevertheless, the central auditory system is capable of learning how to interpret such limited auditory input such that it can extract meaningful information within a few months after implant switch-on. The capacity of the auditory cortex to adapt to new auditory stimuli is an example of intra-modal plasticity — changes within a sensory cortical region as a result of altered statistics of the respective sensory input. However, hearing deprivation before implantation and restoration of hearing capacities after implantation can also induce cross-modal plasticity — changes within a sensory cortical region as a result of altered statistics of a different sensory input. Thereby, a preserved cortical region can, for example, support a deprived cortical region, as in the case of CI users which have been shown to exhibit cross-modal visual-cortex activation for purely auditory stimuli. Before implantation, during the period of hearing deprivation, CI users typically rely on additional visual cues like lip-movements for understanding speech. Therefore, it has been suggested that CI users show a pronounced binding of the auditory and visual systems, which may allow them to integrate auditory and visual speech information more efficiently. The projects included in this thesis investigate auditory, and particularly audiovisual speech processing in CI users. Four event-related potential (ERP) studies approach the matter from different perspectives, each with a distinct focus. The first project investigates how audiovisually presented syllables are processed by CI users with bilateral hearing loss compared to NH controls. Previous ERP studies employing non-linguistic stimuli and studies using different neuroimaging techniques found distinct audiovisual interactions in CI users. However, the precise timecourse of cross-modal visual-cortex recruitment and enhanced audiovisual interaction for speech related stimuli is unknown. With our ERP study we fill this gap, and we present differences in the timecourse of audiovisual interactions as well as in cortical source configurations between CI users and NH controls. The second study focuses on auditory processing in single-sided deaf (SSD) CI users. SSD CI patients experience a maximally asymmetric hearing condition, as they have a CI on one ear and a contralateral NH ear. Despite the intact ear, several behavioural studies have demonstrated a variety of beneficial effects of restoring binaural hearing, but there are only few ERP studies which investigate auditory processing in SSD CI users. Our study investigates whether the side of implantation affects auditory processing and whether auditory processing via the NH ear of SSD CI users works similarly as in NH controls. Given the distinct hearing conditions of SSD CI users, the question arises whether there are any quantifiable differences between CI user with unilateral hearing loss and bilateral hearing loss. In general, ERP studies on SSD CI users are rather scarce, and there is no study on audiovisual processing in particular. Furthermore, there are no reports on lip-reading abilities of SSD CI users. To this end, in the third project we extend the first study by including SSD CI users as a third experimental group. The study discusses both differences and similarities between CI users with bilateral hearing loss and CI users with unilateral hearing loss as well as NH controls and provides — for the first time — insights into audiovisual interactions in SSD CI users. The fourth project investigates the influence of background noise on audiovisual interactions in CI users and whether a noise-reduction algorithm can modulate these interactions. It is known that in environments with competing background noise listeners generally rely more strongly on visual cues for understanding speech and that such situations are particularly difficult for CI users. As shown in previous auditory behavioural studies, the recently introduced noise-reduction algorithm "ForwardFocus" can be a useful aid in such cases. However, the questions whether employing the algorithm is beneficial in audiovisual conditions as well and whether using the algorithm has a measurable effect on cortical processing have not been investigated yet. In this ERP study, we address these questions with an auditory and audiovisual syllable discrimination task. Taken together, the projects included in this thesis contribute to a better understanding of auditory and especially audiovisual speech processing in CI users, revealing distinct processing strategies employed to overcome the limited input provided by a CI. The results have clinical implications, as they suggest that clinical hearing assessments, which are currently purely auditory, should be extended to audiovisual assessments. Furthermore, they imply that rehabilitation including audiovisual training methods may be beneficial for all CI user groups for quickly achieving the most effective CI implantation outcome

The effects of adverse conditions on speech recognition by non-native listeners: Electrophysiological and behavioural evidence

This thesis investigated speech recognition by native (L1) and non-native (L2) listeners (i.e., native English and Korean speakers) in diverse adverse conditions using electroencephalography (EEG) and behavioural measures. Study 1 investigated speech recognition in noise for read and casually produced, spontaneous speech using behavioural measures. The results showed that the detrimental effect of casual speech was greater for L2 than L1 listeners, demonstrating real-life L2 speech recognition problems caused by casual speech. Intelligibility was also shown to decrease when the accents of the talker and listener did not match when listening to casual speech as well as read speech. Study 2 set out to develop EEG methods to measure L2 speech processing difficulties for natural, continuous speech. This study thus examined neural entrainment to the amplitude envelope of speech (i.e., slow amplitude fluctuations in speech) while subjects listened to their L1, L2 and a language that they did not understand. The results demonstrate that neural entrainment to the speech envelope is not modulated by whether or not listeners understand the language, opposite to previously reported positive relationships between speech entrainment and intelligibility. Study 3 investigated speech processing in a two-talker situation using measures of neural entrainment and N400, combined with a behavioural speech recognition task. L2 listeners had greater entrainment for target talkers than did L1 listeners, likely because their difficulty with L2 speech comprehension caused them to focus greater attention on the speech signal. L2 listeners also had a greater degree of lexical processing (i.e., larger N400) for highly predictable words than did native listeners, while native listeners had greater lexical processing when listening to foreign-accented speech. The results suggest that the increased listening effort experienced by L2 listeners during speech recognition modulates their auditory and lexical processing

Physiology, Psychoacoustics and Cognition in Normal and Impaired Hearing

​The International Symposium on Hearing is a prestigious, triennial gathering where world-class scientists present and discuss the most recent advances in the field of human and animal hearing research. The 2015 edition will particularly focus on integrative approaches linking physiological, psychophysical and cognitive aspects of normal and impaired hearing. Like previous editions, the proceedings will contain about 50 chapters ranging from basic to applied research, and of interest to neuroscientists, psychologists, audiologists, engineers, otolaryngologists, and artificial intelligence researchers.