8,763 research outputs found
Optimally Stabilized PET Image Denoising Using Trilateral Filtering
Low-resolution and signal-dependent noise distribution in positron emission
tomography (PET) images makes denoising process an inevitable step prior to
qualitative and quantitative image analysis tasks. Conventional PET denoising
methods either over-smooth small-sized structures due to resolution limitation
or make incorrect assumptions about the noise characteristics. Therefore,
clinically important quantitative information may be corrupted. To address
these challenges, we introduced a novel approach to remove signal-dependent
noise in the PET images where the noise distribution was considered as
Poisson-Gaussian mixed. Meanwhile, the generalized Anscombe's transformation
(GAT) was used to stabilize varying nature of the PET noise. Other than noise
stabilization, it is also desirable for the noise removal filter to preserve
the boundaries of the structures while smoothing the noisy regions. Indeed, it
is important to avoid significant loss of quantitative information such as
standard uptake value (SUV)-based metrics as well as metabolic lesion volume.
To satisfy all these properties, we extended bilateral filtering method into
trilateral filtering through multiscaling and optimal Gaussianization process.
The proposed method was tested on more than 50 PET-CT images from various
patients having different cancers and achieved the superior performance
compared to the widely used denoising techniques in the literature.Comment: 8 pages, 3 figures; to appear in the Lecture Notes in Computer
Science (MICCAI 2014
3D mesh processing using GAMer 2 to enable reaction-diffusion simulations in realistic cellular geometries
Recent advances in electron microscopy have enabled the imaging of single
cells in 3D at nanometer length scale resolutions. An uncharted frontier for in
silico biology is the ability to simulate cellular processes using these
observed geometries. Enabling such simulations requires watertight meshing of
electron micrograph images into 3D volume meshes, which can then form the basis
of computer simulations of such processes using numerical techniques such as
the Finite Element Method. In this paper, we describe the use of our recently
rewritten mesh processing software, GAMer 2, to bridge the gap between poorly
conditioned meshes generated from segmented micrographs and boundary marked
tetrahedral meshes which are compatible with simulation. We demonstrate the
application of a workflow using GAMer 2 to a series of electron micrographs of
neuronal dendrite morphology explored at three different length scales and show
that the resulting meshes are suitable for finite element simulations. This
work is an important step towards making physical simulations of biological
processes in realistic geometries routine. Innovations in algorithms to
reconstruct and simulate cellular length scale phenomena based on emerging
structural data will enable realistic physical models and advance discovery at
the interface of geometry and cellular processes. We posit that a new frontier
at the intersection of computational technologies and single cell biology is
now open.Comment: 39 pages, 14 figures. High resolution figures and supplemental movies
available upon reques
Robust Cardiac Motion Estimation using Ultrafast Ultrasound Data: A Low-Rank-Topology-Preserving Approach
Cardiac motion estimation is an important diagnostic tool to detect heart
diseases and it has been explored with modalities such as MRI and conventional
ultrasound (US) sequences. US cardiac motion estimation still presents
challenges because of the complex motion patterns and the presence of noise. In
this work, we propose a novel approach to estimate the cardiac motion using
ultrafast ultrasound data. -- Our solution is based on a variational
formulation characterized by the L2-regularized class. The displacement is
represented by a lattice of b-splines and we ensure robustness by applying a
maximum likelihood type estimator. While this is an important part of our
solution, the main highlight of this paper is to combine a low-rank data
representation with topology preservation. Low-rank data representation
(achieved by finding the k-dominant singular values of a Casorati Matrix
arranged from the data sequence) speeds up the global solution and achieves
noise reduction. On the other hand, topology preservation (achieved by
monitoring the Jacobian determinant) allows to radically rule out distortions
while carefully controlling the size of allowed expansions and contractions.
Our variational approach is carried out on a realistic dataset as well as on a
simulated one. We demonstrate how our proposed variational solution deals with
complex deformations through careful numerical experiments. While maintaining
the accuracy of the solution, the low-rank preprocessing is shown to speed up
the convergence of the variational problem. Beyond cardiac motion estimation,
our approach is promising for the analysis of other organs that experience
motion.Comment: 15 pages, 10 figures, Physics in Medicine and Biology, 201
Unified Heat Kernel Regression for Diffusion, Kernel Smoothing and Wavelets on Manifolds and Its Application to Mandible Growth Modeling in CT Images
We present a novel kernel regression framework for smoothing scalar surface
data using the Laplace-Beltrami eigenfunctions. Starting with the heat kernel
constructed from the eigenfunctions, we formulate a new bivariate kernel
regression framework as a weighted eigenfunction expansion with the heat kernel
as the weights. The new kernel regression is mathematically equivalent to
isotropic heat diffusion, kernel smoothing and recently popular diffusion
wavelets. Unlike many previous partial differential equation based approaches
involving diffusion, our approach represents the solution of diffusion
analytically, reducing numerical inaccuracy and slow convergence. The numerical
implementation is validated on a unit sphere using spherical harmonics. As an
illustration, we have applied the method in characterizing the localized growth
pattern of mandible surfaces obtained in CT images from subjects between ages 0
and 20 years by regressing the length of displacement vectors with respect to
the template surface.Comment: Accepted in Medical Image Analysi
Invertible Orientation Scores of 3D Images
The enhancement and detection of elongated structures in noisy image data is
relevant for many biomedical applications. To handle complex crossing
structures in 2D images, 2D orientation scores were introduced, which already
showed their use in a variety of applications. Here we extend this work to 3D
orientation scores. First, we construct the orientation score from a given
dataset, which is achieved by an invertible coherent state type of transform.
For this transformation we introduce 3D versions of the 2D cake-wavelets, which
are complex wavelets that can simultaneously detect oriented structures and
oriented edges. For efficient implementation of the different steps in the
wavelet creation we use a spherical harmonic transform. Finally, we show some
first results of practical applications of 3D orientation scores.Comment: ssvm 2015 published version in LNCS contains a mistake (a switch
notation spherical angles) that is corrected in this arxiv versio
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