17,459 research outputs found
Order out of Randomness : Self-Organization Processes in Astrophysics
Self-organization is a property of dissipative nonlinear processes that are
governed by an internal driver and a positive feedback mechanism, which creates
regular geometric and/or temporal patterns and decreases the entropy, in
contrast to random processes. Here we investigate for the first time a
comprehensive number of 16 self-organization processes that operate in
planetary physics, solar physics, stellar physics, galactic physics, and
cosmology. Self-organizing systems create spontaneous {\sl order out of chaos},
during the evolution from an initially disordered system to an ordered
stationary system, via quasi-periodic limit-cycle dynamics, harmonic mechanical
resonances, or gyromagnetic resonances. The internal driver can be gravity,
rotation, thermal pressure, or acceleration of nonthermal particles, while the
positive feedback mechanism is often an instability, such as the
magneto-rotational instability, the Rayleigh-B\'enard convection instability,
turbulence, vortex attraction, magnetic reconnection, plasma condensation, or
loss-cone instability. Physical models of astrophysical self-organization
processes involve hydrodynamic, MHD, and N-body formulations of Lotka-Volterra
equation systems.Comment: 61 pages, 38 Figure
Computational Particle Physics for Event Generators and Data Analysis
High-energy physics data analysis relies heavily on the comparison between
experimental and simulated data as stressed lately by the Higgs search at LHC
and the recent identification of a Higgs-like new boson. The first link in the
full simulation chain is the event generation both for background and for
expected signals. Nowadays event generators are based on the automatic
computation of matrix element or amplitude for each process of interest.
Moreover, recent analysis techniques based on the matrix element likelihood
method assign probabilities for every event to belong to any of a given set of
possible processes. This method originally used for the top mass measurement,
although computing intensive, has shown its power at LHC to extract the new
boson signal from the background.
Serving both needs, the automatic calculation of matrix element is therefore
more than ever of prime importance for particle physics. Initiated in the
eighties, the techniques have matured for the lowest order calculations
(tree-level), but become complex and CPU time consuming when higher order
calculations involving loop diagrams are necessary like for QCD processes at
LHC. New calculation techniques for next-to-leading order (NLO) have surfaced
making possible the generation of processes with many final state particles (up
to 6). If NLO calculations are in many cases under control, although not yet
fully automatic, even higher precision calculations involving processes at
2-loops or more remain a big challenge.
After a short introduction to particle physics and to the related theoretical
framework, we will review some of the computing techniques that have been
developed to make these calculations automatic. The main available packages and
some of the most important applications for simulation and data analysis, in
particular at LHC will also be summarized.Comment: 19 pages, 11 figures, Proceedings of CCP (Conference on Computational
Physics) Oct. 2012, Osaka (Japan) in IOP Journal of Physics: Conference
Serie
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Sutureless fixation of amniotic membrane for therapy of ocular surface disorders
Amniotic membrane is applied to the diseased ocular surface to stimulate wound healing and tissue repair, because it releases supportive growth factors and cytokines. These effects fade within about a week after application, necessitating repeated application. Generally, amniotic membrane is fixed with sutures to the ocular surface, but surgical intervention at the inflamed or diseased site can be detrimental. Therefore, we have developed a system for the mounting of amniotic membrane between two rings for application to a diseased ocular surface without surgical intervention (sutureless amniotic membrane transplantation). With this system, AmnioClip, amniotic membrane can be applied like a large contact lens. First prototypes were tested in an experiment on oneself for wearing comfort. The final system was tested on 7 patients in a pilot study. A possible influence of the ring system on the biological effects of amniotic membrane was analyzed by histochemistry and by analyzing the expression of vascular endothelial growth factor-A (VEGF-A), hepatocyte growth factor (HGF), fibroblast growth factor 2 (FGF 2) and pigment epithelium-derived factor (PEDF) from amniotic membranes before and after therapeutic application. The final product, AmnioClip, showed good tolerance and did not impair the biological effects of amniotic membrane. VEGF-A and PEDF mRNA was expressed in amniotic membrane after storage and mounting before transplantation, but was undetectable after a 7-day application period. Consequently, transplantation of amniotic membranes with AmnioClip provides a sutureless and hence improved therapeutic strategy for corneal surface disorders
Medicine in the early twenty-first century: Paradigm and anticipation - EPMA position paper 2016
Challenges of “standardisation” and “individualisation” have always been characteristic for medical services. In terms of individualisation, the best possible individual care is the ethical imperative of medicine, and it is a good right of any patient to receive it. However, in terms of standardisation, all the available treatments are based on guideline recommendations derived from large multi-centre trials with many thousands of patients involved. In the most optimal way, the standardisation and individualisation should go hand-in-hand, in order to identify the right patient treating him/her with the right medication and the right dose at the right time point!
Further, in paradigm and anticipation, there is a big discrepancy between “disease care” and “health care” which dramatically impacts ethical and economical aspects of medical services.
Several approaches have been suggested in ancient and modern medicine to conduct medical services in a possibly optimal way. What is the difference amongst all of them and how big is the potential beyond corresponding approach to satisfy the needs of the individual, the patient, professional groups involved and society at large?
On behalf of the “European Association for Predictive, Preventive and Personalised Medicine,” the dedicated EPMA working group provides a deep analysis in the issue followed by the expert recommendations considering the multifaceted aspects of both “disease care” and “health care” practices including ethics and economy, life quality of individuals and patients, interests of professional groups involved, benefits of subpopulations, health care system(s) and society as a whole
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