Can we identify non-stationary dynamics of trial-to-trial variability?"

Identifying sources of the apparent variability in non-stationary scenarios is a fundamental problem in many biological data analysis settings. For instance, neurophysiological responses to the same task often vary from each repetition of the same experiment (trial) to the next. The origin and functional role of this observed variability is one of the fundamental questions in neuroscience. The nature of such trial-to-trial dynamics however remains largely elusive to current data analysis approaches. A range of strategies have been proposed in modalities such as electro-encephalography but gaining a fundamental insight into latent sources of trial-to-trial variability in neural recordings is still a major challenge. In this paper, we present a proof-of-concept study to the analysis of trial-to-trial variability dynamics founded on non-autonomous dynamical systems. At this initial stage, we evaluate the capacity of a simple statistic based on the behaviour of trajectories in classification settings, the trajectory coherence, in order to identify trial-to-trial dynamics. First, we derive the conditions leading to observable changes in datasets generated by a compact dynamical system (the Duffing equation). This canonical system plays the role of a ubiquitous model of non-stationary supervised classification problems. Second, we estimate the coherence of class-trajectories in empirically reconstructed space of system states. We show how this analysis can discern variations attributable to non-autonomous deterministic processes from stochastic fluctuations. The analyses are benchmarked using simulated and two different real datasets which have been shown to exhibit attractor dynamics. As an illustrative example, we focused on the analysis of the rat's frontal cortex ensemble dynamics during a decision-making task. Results suggest that, in line with recent hypotheses, rather than internal noise, it is the deterministic trend which most likely underlies the observed trial-to-trial variability. Thus, the empirical tool developed within this study potentially allows us to infer the source of variability in in-vivo neural recordings

Connectivity Analysis in EEG Data: A Tutorial Review of the State of the Art and Emerging Trends

Understanding how different areas of the human brain communicate with each other is a crucial issue in neuroscience. The concepts of structural, functional and effective connectivity have been widely exploited to describe the human connectome, consisting of brain networks, their structural connections and functional interactions. Despite high-spatial-resolution imaging techniques such as functional magnetic resonance imaging (fMRI) being widely used to map this complex network of multiple interactions, electroencephalographic (EEG) recordings claim high temporal resolution and are thus perfectly suitable to describe either spatially distributed and temporally dynamic patterns of neural activation and connectivity. In this work, we provide a technical account and a categorization of the most-used data-driven approaches to assess brain-functional connectivity, intended as the study of the statistical dependencies between the recorded EEG signals. Different pairwise and multivariate, as well as directed and non-directed connectivity metrics are discussed with a pros-cons approach, in the time, frequency, and information-theoretic domains. The establishment of conceptual and mathematical relationships between metrics from these three frameworks, and the discussion of novel methodological approaches, will allow the reader to go deep into the problem of inferring functional connectivity in complex networks. Furthermore, emerging trends for the description of extended forms of connectivity (e.g., high-order interactions) are also discussed, along with graph-theory tools exploring the topological properties of the network of connections provided by the proposed metrics. Applications to EEG data are reviewed. In addition, the importance of source localization, and the impacts of signal acquisition and pre-processing techniques (e.g., filtering, source localization, and artifact rejection) on the connectivity estimates are recognized and discussed. By going through this review, the reader could delve deeply into the entire process of EEG pre-processing and analysis for the study of brain functional connectivity and learning, thereby exploiting novel methodologies and approaches to the problem of inferring connectivity within complex networks

System approach to robust acoustic echo cancellation through semi-blind source separation based on independent component analysis

We live in a dynamic world full of noises and interferences. The conventional acoustic echo cancellation (AEC) framework based on the least mean square (LMS) algorithm by itself lacks the ability to handle many secondary signals that interfere with the adaptive filtering process, e.g., local speech and background noise. In this dissertation, we build a foundation for what we refer to as the system approach to signal enhancement as we focus on the AEC problem. We first propose the residual echo enhancement (REE) technique that utilizes the error recovery nonlinearity (ERN) to "enhances" the filter estimation error prior to the filter adaptation. The single-channel AEC problem can be viewed as a special case of semi-blind source separation (SBSS) where one of the source signals is partially known, i.e., the far-end microphone signal that generates the near-end acoustic echo. SBSS optimized via independent component analysis (ICA) leads to the system combination of the LMS algorithm with the ERN that allows for continuous and stable adaptation even during double talk. Second, we extend the system perspective to the decorrelation problem for AEC, where we show that the REE procedure can be applied effectively in a multi-channel AEC (MCAEC) setting to indirectly assist the recovery of lost AEC performance due to inter-channel correlation, known generally as the "non-uniqueness" problem. We develop a novel, computationally efficient technique of frequency-domain resampling (FDR) that effectively alleviates the non-uniqueness problem directly while introducing minimal distortion to signal quality and statistics. We also apply the system approach to the multi-delay filter (MDF) that suffers from the inter-block correlation problem. Finally, we generalize the MCAEC problem in the SBSS framework and discuss many issues related to the implementation of an SBSS system. We propose a constrained batch-online implementation of SBSS that stabilizes the convergence behavior even in the worst case scenario of a single far-end talker along with the non-uniqueness condition on the far-end mixing system. The proposed techniques are developed from a pragmatic standpoint, motivated by real-world problems in acoustic and audio signal processing. Generalization of the orthogonality principle to the system level of an AEC problem allows us to relate AEC to source separation that seeks to maximize the independence, hence implicitly the orthogonality, not only between the error signal and the far-end signal, but rather, among all signals involved. The system approach, for which the REE paradigm is just one realization, enables the encompassing of many traditional signal enhancement techniques in analytically consistent yet practically effective manner for solving the enhancement problem in a very noisy and disruptive acoustic mixing environment.PhDCommittee Chair: Biing-Hwang Juang; Committee Member: Brani Vidakovic; Committee Member: David V. Anderson; Committee Member: Jeff S. Shamma; Committee Member: Xiaoli M

Comprehensive Survey and Taxonomies of False Injection Attacks in Smart Grid: Attack Models, Targets, and Impacts

Smart Grid has rapidly transformed the centrally controlled power system into a massively interconnected cyber-physical system that benefits from the revolutions happening in the communications (e.g. 5G) and the growing proliferation of the Internet of Things devices (such as smart metres and intelligent electronic devices). While the convergence of a significant number of cyber-physical elements has enabled the Smart Grid to be far more efficient and competitive in addressing the growing global energy challenges, it has also introduced a large number of vulnerabilities culminating in violations of data availability, integrity, and confidentiality. Recently, false data injection (FDI) has become one of the most critical cyberattacks, and appears to be a focal point of interest for both research and industry. To this end, this paper presents a comprehensive review in the recent advances of the FDI attacks, with particular emphasis on 1) adversarial models, 2) attack targets, and 3) impacts in the Smart Grid infrastructure. This review paper aims to provide a thorough understanding of the incumbent threats affecting the entire spectrum of the Smart Grid. Related literature are analysed and compared in terms of their theoretical and practical implications to the Smart Grid cybersecurity. In conclusion, a range of technical limitations of existing false data attack research is identified, and a number of future research directions is recommended.Comment: Double-column of 24 pages, prepared based on IEEE Transaction articl

Disentangling causal webs in the brain using functional Magnetic Resonance Imaging: A review of current approaches

In the past two decades, functional Magnetic Resonance Imaging has been used to relate neuronal network activity to cognitive processing and behaviour. Recently this approach has been augmented by algorithms that allow us to infer causal links between component populations of neuronal networks. Multiple inference procedures have been proposed to approach this research question but so far, each method has limitations when it comes to establishing whole-brain connectivity patterns. In this work, we discuss eight ways to infer causality in fMRI research: Bayesian Nets, Dynamical Causal Modelling, Granger Causality, Likelihood Ratios, LiNGAM, Patel's Tau, Structural Equation Modelling, and Transfer Entropy. We finish with formulating some recommendations for the future directions in this area