Bayesian Approximate Kernel Regression with Variable Selection

Nonlinear kernel regression models are often used in statistics and machine learning because they are more accurate than linear models. Variable selection for kernel regression models is a challenge partly because, unlike the linear regression setting, there is no clear concept of an effect size for regression coefficients. In this paper, we propose a novel framework that provides an effect size analog of each explanatory variable for Bayesian kernel regression models when the kernel is shift-invariant --- for example, the Gaussian kernel. We use function analytic properties of shift-invariant reproducing kernel Hilbert spaces (RKHS) to define a linear vector space that: (i) captures nonlinear structure, and (ii) can be projected onto the original explanatory variables. The projection onto the original explanatory variables serves as an analog of effect sizes. The specific function analytic property we use is that shift-invariant kernel functions can be approximated via random Fourier bases. Based on the random Fourier expansion we propose a computationally efficient class of Bayesian approximate kernel regression (BAKR) models for both nonlinear regression and binary classification for which one can compute an analog of effect sizes. We illustrate the utility of BAKR by examining two important problems in statistical genetics: genomic selection (i.e. phenotypic prediction) and association mapping (i.e. inference of significant variants or loci). State-of-the-art methods for genomic selection and association mapping are based on kernel regression and linear models, respectively. BAKR is the first method that is competitive in both settings.Comment: 22 pages, 3 figures, 3 tables; theory added; new simulations presented; references adde

Model Selection for Support Vector Machine Classification

We address the problem of model selection for Support Vector Machine (SVM) classification. For fixed functional form of the kernel, model selection amounts to tuning kernel parameters and the slack penalty coefficient $C$. We begin by reviewing a recently developed probabilistic framework for SVM classification. An extension to the case of SVMs with quadratic slack penalties is given and a simple approximation for the evidence is derived, which can be used as a criterion for model selection. We also derive the exact gradients of the evidence in terms of posterior averages and describe how they can be estimated numerically using Hybrid Monte Carlo techniques. Though computationally demanding, the resulting gradient ascent algorithm is a useful baseline tool for probabilistic SVM model selection, since it can locate maxima of the exact (unapproximated) evidence. We then perform extensive experiments on several benchmark data sets. The aim of these experiments is to compare the performance of probabilistic model selection criteria with alternatives based on estimates of the test error, namely the so-called ``span estimate'' and Wahba's Generalized Approximate Cross-Validation (GACV) error. We find that all the ``simple'' model criteria (Laplace evidence approximations, and the Span and GACV error estimates) exhibit multiple local optima with respect to the hyperparameters. While some of these give performance that is competitive with results from other approaches in the literature, a significant fraction lead to rather higher test errors. The results for the evidence gradient ascent method show that also the exact evidence exhibits local optima, but these give test errors which are much less variable and also consistently lower than for the simpler model selection criteria

Statistical Mechanics of Learning: A Variational Approach for Real Data

Using a variational technique, we generalize the statistical physics approach of learning from random examples to make it applicable to real data. We demonstrate the validity and relevance of our method by computing approximate estimators for generalization errors that are based on training data alone.Comment: 4 pages, 2 figure

Linear system identification using stable spline kernels and PLQ penalties

The classical approach to linear system identification is given by parametric Prediction Error Methods (PEM). In this context, model complexity is often unknown so that a model order selection step is needed to suitably trade-off bias and variance. Recently, a different approach to linear system identification has been introduced, where model order determination is avoided by using a regularized least squares framework. In particular, the penalty term on the impulse response is defined by so called stable spline kernels. They embed information on regularity and BIBO stability, and depend on a small number of parameters which can be estimated from data. In this paper, we provide new nonsmooth formulations of the stable spline estimator. In particular, we consider linear system identification problems in a very broad context, where regularization functionals and data misfits can come from a rich set of piecewise linear quadratic functions. Moreover, our anal- ysis includes polyhedral inequality constraints on the unknown impulse response. For any formulation in this class, we show that interior point methods can be used to solve the system identification problem, with complexity O(n3)+O(mn2) in each iteration, where n and m are the number of impulse response coefficients and measurements, respectively. The usefulness of the framework is illustrated via a numerical experiment where output measurements are contaminated by outliers.Comment: 8 pages, 2 figure

Rejoinder to "Support Vector Machines with Applications"

Rejoinder to ``Support Vector Machines with Applications'' [math.ST/0612817]Comment: Published at http://dx.doi.org/10.1214/088342306000000501 in the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org