Automatic Detection of Optic Disc Based on PCA and Mathematical Morphology

The algorithm proposed in this paper allows to automatically segment the optic disc from a fundus image. The goal is to facilitate the early detection of certain pathologies and to fully automate the process so as to avoid specialist intervention. The method proposed for the extraction of the optic disc contour is mainly based on mathematical morphology along with principal component analysis (PCA). It makes use of different operations such as generalized distance function (GDF), a variant of the watershed transformation, the stochastic watershed, and geodesic transformations. The input of the segmentation method is obtained through PCA. The purpose of using PCA is to achieve the grey-scale image that better represents the original RGB image. The implemented algorithm has been validated on five public databases obtaining promising results. The average values obtained (a Jaccard s and Dice s coefficients of 0.8200 and 0.8932, respectively, an accuracy of 0.9947, and a true positive and false positive fractions of 0.9275 and 0.0036) demonstrate that this method is a robust tool for the automatic segmentation of the optic disc. Moreover, it is fairly reliable since it works properly on databases with a large degree of variability and improves the results of other state-of-the-art methods.This work was supported in part by the project IMIDTA/2010/47 and in part by projects Consolider-C (SEJ2006-14301/PSIC), "CIBER of Physiopathology of Obesity and Nutrition, an initiative of ISCIII" and Excellence Research Program PROMETEO (Generalitat Valenciana. Conselleria de Educacion, 2008-157).Morales Martínez, S.; Naranjo Ornedo, V.; Angulo Lopez, J.; Alcañiz Raya, ML. (2013). Automatic Detection of Optic Disc Based on PCA and Mathematical Morphology. IEEE Transactions on Medical Imaging. 32(4):786-796. https://doi.org/10.1109/TMI.2013.2238244S78679632

Structure analysis and lesion detection from retinal fundus images

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Ocular pathology is one of the main health problems worldwide. The number of people with retinopathy symptoms has increased considerably in recent years. Early adequate treatment has demonstrated to be effective to avoid the loss of the vision. The analysis of fundus images is a non intrusive option for periodical retinal screening. Different models designed for the analysis of retinal images are based on supervised methods, which require of hand labelled images and processing time as part of the training stage. On the other hand most of the methods have been designed under the basis of specific characteristics of the retinal images (e.g. field of view, resolution). This compromises its performance to a reduce group of retinal image with similar features. For these reasons an unsupervised model for the analysis of retinal image is required, a model that can work without human supervision or interaction. And that is able to perform on retinal images with different characteristics. In this research, we have worked on the development of this type of model. The system locates the eye structures (e.g. optic disc and blood vessels) as first step. Later, these structures are masked out from the retinal image in order to create a clear field to perform the lesion detection. We have selected the Graph Cut technique as a base to design the retinal structures segmentation methods. This selection allows incorporating prior knowledge to constraint the searching for the optimal segmentation. Different link weight assignments were formulated in order to attend the specific needs of the retinal structures (e.g. shape). This research project has put to work together the fields of image processing and ophthalmology to create a novel system that contribute significantly to the state of the art in medical image analysis. This new knowledge provides a new alternative to address the analysis of medical images and opens a new panorama for researchers exploring this research area.Mexican National Council of Science and Technolog

Change blindness: eradication of gestalt strategies

Arrays of eight, texture-defined rectangles were used as stimuli in a one-shot change blindness (CB) task where there was a 50% chance that one rectangle would change orientation between two successive presentations separated by an interval. CB was eliminated by cueing the target rectangle in the first stimulus, reduced by cueing in the interval and unaffected by cueing in the second presentation. This supports the idea that a representation was formed that persisted through the interval before being 'overwritten' by the second presentation (Landman et al, 2003 Vision Research 43149–164]. Another possibility is that participants used some kind of grouping or Gestalt strategy. To test this we changed the spatial position of the rectangles in the second presentation by shifting them along imaginary spokes (by ±1 degree) emanating from the central fixation point. There was no significant difference seen in performance between this and the standard task [F(1,4)=2.565, p=0.185]. This may suggest two things: (i) Gestalt grouping is not used as a strategy in these tasks, and (ii) it gives further weight to the argument that objects may be stored and retrieved from a pre-attentional store during this task

Image classification : a study in age-related macular degeneration screening

This thesis presents research work conducted in the field of image mining. More specifically, the work is directed at the employment of image classification techniques to classify images where features of interest are very difficult to distinguish. In this context, three distinct approaches to image classification are proposed. The first is founded on a time series based image representation, whereby each image is defined in terms of histograms that in turn are presented as "time series" curves. A Case Based Reasoning (CBR) mechanism, coupled with a Time Series Analysis (TSA) technique, is then applied to classify new "unseen" images. The second proposed approach uses statistical parameters that are extracted from the images either directly or indirectly. These parameters are then represented in a tabular form from which a classifier can be built on. The third is founded on a tree based representation, whereby a hierarchical decomposition technique is proposed. The images are successively decomposed into smaller segments until each segment describes a uniform set of features. The resulting tree structures allow for the application of weighted frequent sub-graph mining to identify feature vectors representing each image. A standard classifier generator is then applied to this feature vector representation to produce the desired classifier. The presented evaluation, applied to all three approaches, is directed at the classification of retinal colour fundus images; the aim is to screen for an eye condition known as Age-related Macular Degeneration (AMD). Of all the approaches considered in this thesis, the tree based representation coupled with weighted frequent sub-graph mining produced the best performance. The evaluation also indicated that a sound foundation has been established for future potential AMD screening programmes

Object Recognition

Vision-based object recognition tasks are very familiar in our everyday activities, such as driving our car in the correct lane. We do these tasks effortlessly in real-time. In the last decades, with the advancement of computer technology, researchers and application developers are trying to mimic the human's capability of visually recognising. Such capability will allow machine to free human from boring or dangerous jobs

A computational approach to motivated behaviour and apathy

The loss of motivation and goal-directed behaviour is characteristic of apathy. Across a wide range of neuropsychiatric disorders, including Huntington’s disease (HD), apathy is poorly understood, associated with significant morbidity, and is hard to treat. One of the challenges in understanding the neural basis of apathy is moving from phenomenology and behavioural dysfunction to neural circuits in a principled manner. The computational framework offers one such approach. I adopt this framework to better understand motivated behaviour and apathy in four complementary projects. At the heart of many apathy formulations is impaired self-initiation of goal-directed behaviour. An influential computational theory proposes that “opportunity cost”, the amount of reward we stand to lose by not taking actions per unit time, is a key variable in governing the timing of self-initiated behaviour. Using a novel task, I found that free-operant behaviour in healthy participants both in laboratory conditions and in online testing, conforms to predictions of this computational model. Furthermore, in both studies I found that in younger adults sensitivity to opportunity cost predicted behavioural apathy scores. Similar pilot results were found in a cohort of patients with HD. These data suggest that opportunity cost may be an important computational variable relevant for understanding a core feature of apathy – the timing of self-initiated behaviour. In my second project, I used a reinforcement learning paradigm to probe for early dysfunction in a cohort of HD gene carriers approximately 25 years from clinical onset. Based on empirical data and computational models of basal ganglia function I predicted that asymmetry in learning from gains and losses may be an early feature of carrying the HD gene. As predicted, in this task fMRI study, HD gene carriers demonstrated an exaggerated neural response to gains as compared to losses. Gene carriers also differed in the neural response to expected value suggesting that carrying the HD gene is associated with altered processing of valence and value decades from onset. Finally, based on neurocomputational models of basal ganglia pathway function, I tested the hypothesis that apathy in HD would be associated with the involvement of the direct pathway. Support for this hypothesis was found in two related projects. Firstly, using data from a large international HD cohort study, I found that apathy was associated with motor features of the disease thought to represent direct pathway involvement. Secondly, I tested this hypothesis in vivo using resting state fMRI data and a model of basal ganglia connectivity in a large peri-manifest HD cohort. In keeping with my predictions, whilst emerging motor signs were associated with changes in the indirect pathway, apathy scores were associated with connectivity changes in the direct pathway connectivity within my model. For patients with apathy across neuropsychiatry there is an urgent need to understand the neural basis of motivated behaviour in order to develop novel therapies. In this thesis, I have used a computational framework to develop and test a range of hypotheses to advance this understanding. In particular, I have focussed on the computational factors which drive us to self-initiate, their potential neural underpinnings and the relevance of these models for apathy in patients with HD. The data I present supports the hypothesis that opportunity cost and basal ganglia pathway connectivity may be two important components necessary to generate motivated behaviour and contribute to the development of apathy in HD

Cooperative Radio Communications for Green Smart Environments

The demand for mobile connectivity is continuously increasing, and by 2020 Mobile and Wireless Communications will serve not only very dense populations of mobile phones and nomadic computers, but also the expected multiplicity of devices and sensors located in machines, vehicles, health systems and city infrastructures. Future Mobile Networks are then faced with many new scenarios and use cases, which will load the networks with different data traffic patterns, in new or shared spectrum bands, creating new specific requirements. This book addresses both the techniques to model, analyse and optimise the radio links and transmission systems in such scenarios, together with the most advanced radio access, resource management and mobile networking technologies. This text summarises the work performed by more than 500 researchers from more than 120 institutions in Europe, America and Asia, from both academia and industries, within the framework of the COST IC1004 Action on "Cooperative Radio Communications for Green and Smart Environments". The book will have appeal to graduates and researchers in the Radio Communications area, and also to engineers working in the Wireless industry. Topics discussed in this book include: • Radio waves propagation phenomena in diverse urban, indoor, vehicular and body environments• Measurements, characterization, and modelling of radio channels beyond 4G networks• Key issues in Vehicle (V2X) communication• Wireless Body Area Networks, including specific Radio Channel Models for WBANs• Energy efficiency and resource management enhancements in Radio Access Networks• Definitions and models for the virtualised and cloud RAN architectures• Advances on feasible indoor localization and tracking techniques• Recent findings and innovations in antenna systems for communications• Physical Layer Network Coding for next generation wireless systems• Methods and techniques for MIMO Over the Air (OTA) testin

Cooperative Radio Communications for Green Smart Environments

The demand for mobile connectivity is continuously increasing, and by 2020 Mobile and Wireless Communications will serve not only very dense populations of mobile phones and nomadic computers, but also the expected multiplicity of devices and sensors located in machines, vehicles, health systems and city infrastructures. Future Mobile Networks are then faced with many new scenarios and use cases, which will load the networks with different data traffic patterns, in new or shared spectrum bands, creating new specific requirements. This book addresses both the techniques to model, analyse and optimise the radio links and transmission systems in such scenarios, together with the most advanced radio access, resource management and mobile networking technologies. This text summarises the work performed by more than 500 researchers from more than 120 institutions in Europe, America and Asia, from both academia and industries, within the framework of the COST IC1004 Action on "Cooperative Radio Communications for Green and Smart Environments". The book will have appeal to graduates and researchers in the Radio Communications area, and also to engineers working in the Wireless industry. Topics discussed in this book include: • Radio waves propagation phenomena in diverse urban, indoor, vehicular and body environments• Measurements, characterization, and modelling of radio channels beyond 4G networks• Key issues in Vehicle (V2X) communication• Wireless Body Area Networks, including specific Radio Channel Models for WBANs• Energy efficiency and resource management enhancements in Radio Access Networks• Definitions and models for the virtualised and cloud RAN architectures• Advances on feasible indoor localization and tracking techniques• Recent findings and innovations in antenna systems for communications• Physical Layer Network Coding for next generation wireless systems• Methods and techniques for MIMO Over the Air (OTA) testin

Exploiting Spatio-Temporal Coherence for Video Object Detection in Robotics

This paper proposes a method to enhance video object detection for indoor environments in robotics. Concretely, it exploits knowledge about the camera motion between frames to propagate previously detected objects to successive frames. The proposal is rooted in the concepts of planar homography to propose regions of interest where to find objects, and recursive Bayesian filtering to integrate observations over time. The proposal is evaluated on six virtual, indoor environments, accounting for the detection of nine object classes over a total of ∼ 7k frames. Results show that our proposal improves the recall and the F1-score by a factor of 1.41 and 1.27, respectively, as well as it achieves a significant reduction of the object categorization entropy (58.8%) when compared to a two-stage video object detection method used as baseline, at the cost of small time overheads (120 ms) and precision loss (0.92).</p