24,733 research outputs found
Microdevices for studies of cultured neural networks
A cultured network has the advantages that the network is two-dimensional and easily observed, that the biochemical environment can be controlled, and that conventional electrodes as well as extracellular electrodes incorporated into the cultured substrate can be used to selectively stimulate and record from individual neurons in the network. It is possible to study small numbers of connected neurons, from a few to hundreds. This talk will describe two techniques, the multielectrode array and the silicon neurochip, and their application to long-term communication with a network by means of simultaneous recording or stimulation of many neurons
A silicon model of auditory localization
The barn owl accurately localizes sounds in the azimuthal plane, using interaural time difference as a cue. The time-coding pathway in the owl's brainstem encodes a neural map of azimuth, by processing interaural timing information. We have built a silicon model of the time-coding pathway of the owl. The integrated circuit models the structure as well as the function of the pathway; most subcircuits in the chip have an anatomical correlate. The chip computes all outputs in real time, using analog, continuous-time processing
Neuromorphic analogue VLSI
Neuromorphic systems emulate the organization and function of nervous systems. They are usually composed of analogue electronic circuits that are fabricated in the complementary metal-oxide-semiconductor (CMOS) medium using very large-scale integration (VLSI) technology. However, these neuromorphic systems are not another kind of digital computer in which abstract neural networks are simulated symbolically in terms of their mathematical behavior. Instead, they directly embody, in the physics of their CMOS circuits, analogues of the physical processes that underlie the computations of neural systems. The significance of neuromorphic systems is that they offer a method of exploring neural computation in a medium whose physical behavior is analogous to that of biological nervous systems and that operates in real time irrespective of size. The implications of this approach are both scientific and practical. The study of neuromorphic systems provides a bridge between levels of understanding. For example, it provides a link between the physical processes of neurons and their computational significance. In addition, the synthesis of neuromorphic systems transposes our knowledge of neuroscience into practical devices that can interact directly with the real world in the same way that biological nervous systems do
A compact aVLSI conductance-based silicon neuron
We present an analogue Very Large Scale Integration (aVLSI) implementation
that uses first-order lowpass filters to implement a conductance-based silicon
neuron for high-speed neuromorphic systems. The aVLSI neuron consists of a soma
(cell body) and a single synapse, which is capable of linearly summing both the
excitatory and inhibitory postsynaptic potentials (EPSP and IPSP) generated by
the spikes arriving from different sources. Rather than biasing the silicon
neuron with different parameters for different spiking patterns, as is
typically done, we provide digital control signals, generated by an FPGA, to
the silicon neuron to obtain different spiking behaviours. The proposed neuron
is only ~26.5 um2 in the IBM 130nm process and thus can be integrated at very
high density. Circuit simulations show that this neuron can emulate different
spiking behaviours observed in biological neurons.Comment: BioCAS-201
A long-term in vitro silicon-based microelectrode-neuron connection
A novel method for long-term recording and simulation applicable to cultured neurons has been developed. Silicon-based microelectrodes have been fabricated using integrated-circuit technology and micromachining. The chronic connection is made by positioning the tip of the `diving-board electrode' into contact with the top of the cell body. The electrode support structure is then glued to the bottom of the culture dish. Two-way electrical connections to Helisoma B19 neurons have been maintained for up to four days. This capability makes it possible to conduct experiments that are not practical using conventional techniques
- …