125,909 research outputs found
Concussion signs and symptoms checklist
Use this checklist to monitor students who come to your office with a head injury. Students should be monitored for a minimum of 30 minutes. Check for signs or symptoms when the student first arrives at your office, fifteen minutes later, and at the end of 30 minutes. Students who experience one or more of the signs or symptoms of concussion after a bump, blow, or jolt to the head should be referred to a health care professional with experience in evaluating for concussion. For those instances when a parent is coming to take the student to a health care professional, observe the student for any new or worsening symptoms right before the student leaves. Send a copy of this checklist with the student for the health care professional to review."May 2010."Available via the World Wide Web as an Acrobat .pdf file (127.94 KB, 2 p.)
Signs and Symptoms, Management and Outcomes
Data collected during the 2012 Ebola virus disease (EVD) epidemic in the
Democratic Republic of the Congo were analysed for clinical signs, symptoms
and case fatality of EVD caused by Bundibugyo virus (BDBV), establishment of
differential diagnoses, description of medical treatment and evaluation of the
quality of clinical documentation. In a quantitative observational prospective
study, global epidemiological data from 52 patients (34 patients within the
community, 18 patients treated in the Ebola Treatment Centre) were entered
anonymously into a database, subsequently matched and analysed. Relevant
findings include an over-representation of females among community EVD cases
(85.3%) and of community EVD cases in the age group of 15-54 years (82.4%).
All ETC patients had fever (55.6% of all 18 ETC patients during their hospital
stay) or self-reported fever (88.2% upon admission) at some point of time
during their illness. Major symptoms of ETC patients during hospital stay
included asthenia (82.4%), anorexia (82.4%), myalgia (70.6%), sore
throat/difficulty swallowing (70.6%), arthralgia (76.5%) and nausea (70.6%).
Gastrointestinal signs and symptoms (nausea, diarrhoea, vomiting) (76.4%) as
well as general pain (94.1%) were frequent in ETC patients. The median
duration of EVD was 18 days, while the mean incubation period was 11.3 days.
Differential diagnosis of EVD included malaria (28.3%), intestinal parasitosis
(10.9%), and infectious syndrome (10.9%). There was also an important
variation in clinical evolvement. Quality of documentation was adversely
affected by the way patient file contents were transferred from inside to
outside the high-risk zone, entailing a mean mismatch value of 27.3% between
patient file contents inside vs. outside the high-risk zone. This study adds
further description of EVD (frequently non-specific signs and symptoms, non
frequent bleeding, a long incubation period, long duration of disease) and
emphasizes the need for improving clinical monitoring and documentation in EVD
outbreak settings
Analysis of the human diseasome reveals phenotype modules across common, genetic, and infectious diseases
Phenotypes are the observable characteristics of an organism arising from its
response to the environment. Phenotypes associated with engineered and natural
genetic variation are widely recorded using phenotype ontologies in model
organisms, as are signs and symptoms of human Mendelian diseases in databases
such as OMIM and Orphanet. Exploiting these resources, several computational
methods have been developed for integration and analysis of phenotype data to
identify the genetic etiology of diseases or suggest plausible interventions. A
similar resource would be highly useful not only for rare and Mendelian
diseases, but also for common, complex and infectious diseases. We apply a
semantic text- mining approach to identify the phenotypes (signs and symptoms)
associated with over 8,000 diseases. We demonstrate that our method generates
phenotypes that correctly identify known disease-associated genes in mice and
humans with high accuracy. Using a phenotypic similarity measure, we generate a
human disease network in which diseases that share signs and symptoms cluster
together, and we use this network to identify phenotypic disease modules
Complex interaction of sensory and motor signs and symptoms in chronic CRPS.
Spontaneous pain, hyperalgesia as well as sensory abnormalities, autonomic, trophic, and motor disturbances are key features of Complex Regional Pain Syndrome (CRPS). This study was conceived to comprehensively characterize the interaction of these symptoms in 118 patients with chronic upper limb CRPS (duration of disease: 43±23 months). Disease-related stress, depression, and the degree of accompanying motor disability were likewise assessed. Stress and depression were measured by Posttraumatic Stress Symptoms Score and Center for Epidemiological Studies Depression Test. Motor disability of the affected hand was determined by Sequential Occupational Dexterity Assessment and Michigan Hand Questionnaire. Sensory changes were assessed by Quantitative Sensory Testing according to the standards of the German Research Network on Neuropathic Pain. Almost two-thirds of all patients exhibited spontaneous pain at rest. Hand force as well as hand motor function were found to be substantially impaired. Results of Quantitative Sensory Testing revealed a distinct pattern of generalized bilateral sensory loss and hyperalgesia, most prominently to blunt pressure. Patients reported substantial motor complaints confirmed by the objective motor disability testings. Interestingly, patients displayed clinically relevant levels of stress and depression. We conclude that chronic CRPS is characterized by a combination of ongoing pain, pain-related disability, stress and depression, potentially triggered by peripheral nerve/tissue damage and ensuing sensory loss. In order to consolidate the different dimensions of disturbances in chronic CRPS, we developed a model based on interaction analysis suggesting a complex hierarchical interaction of peripheral (injury/sensory loss) and central factors (pain/disability/stress/depression) predicting motor dysfunction and hyperalgesia
Concussion signs and symptoms checklist
Revised August 2019Use this checklist to monitor students who come to your office with a head injury. Students should be monitored for a minimum of 30 minutes. Check for signs or symptoms when the student first arrives at your office, 15 minutes later, and at the end of 30 minutes.Students who experience one or more of the signs or symptoms of concussion after a bump, blow, or jolt to the head should be referred to a healthcare professional with experience in evaluating for concussion. For those instances when a parent is coming to take the student to a healthcare professional, observe the student for any new or worsening symptoms right before the student leaves. Send a copy of this checklist with the student for the healthcare professional to review.To learn more, go to cdc.gov/HEADSUPtbi_schools_checklist_508-a.pd
Oral Manifestations in Acute Leukemia as the First Sign; The Interdisciplinary Approach of Diagnosis and Treatment
Systemic diseases often present associated oral signs and symptoms, which can occur either from the beginning of the disease or during its evolution. In some cases the oral manifestations reveal an undetected and severe disease, like leukemia. According to the encountered oral signs and symptoms and their response to topical/ dental treatment, the dentist and physician should take into account specific additional tests, which could highlight a possible associated systemic disease.
The most frequent oral manifestations associated with leukemia are represented by paleness of oral mucosa/ local abnormal colour of the gum, gingival petechiae, ecchymosis, bleeding associating painless gingival hyperplasia, hemorrhages, ulcerative necrotic lesions and buccal infections. We presented in this paper the relevant literature data in respect to the oral manifestations encountered in leukemia, exemplified with two suggestive cases.
As a conclusion, dentists should be advised not only to recognize and treat the encountered oral lesions but also to refer the patient to specialized professionals for additional investigations, especially in the situation when suspect a severe systemic disease that require a precocious diagnosis or in the case when the establishment of diagnosis exceed the possibilities of the usual tests. Chemotherapy administration in association with topical/ oral solutions often leads to total or partial remission of the oral signs and symptoms
Visual signs and symptoms of corticobasal degeneration
Corticobasal degeneration is a rare, progressive neurodegenerative disease and a member of the 'parkinsonian' group of disorders, which also includes Parkinson's disease, progressive supranuclear palsy, dementia with Lewy bodies and multiple system atrophy. The most common initial symptom is limb clumsiness, usually affecting one side of the body, with or without accompanying rigidity or tremor. Subsequently, the disease affects gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs. Corticobasal degeneration can be difficult to distinguish from other parkinsonian syndromes but if ocular signs and symptoms are present, they may aid clinical diagnosis. Typical ocular features include increased latency of saccadic eye movements ipsilateral to the side exhibiting apraxia, impaired smooth pursuit movements and visuo-spatial dysfunction, especially involving spatial rather than object-based tasks. Less typical features include reduction in saccadic velocity, vertical gaze palsy, visual hallucinations, sleep disturbance and an impaired electroretinogram. Aspects of primary vision such as visual acuity and colour vision are usually unaffected. Management of the condition to deal with problems of walking, movement, daily tasks and speech problems is an important aspect of the disease
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