Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis

Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage. Chronic myeloid leukaemia (CML) arises from a genetic alteration in a normal haemopoietic stem cell (HSC) giving rise to a leukaemic stem cell (LSC) within the bone marrow (BM) ‘niche’. CML is characterised by the presence of the oncogenic tyrosine kinase fusion protein breakpoint cluster region-abelson murine leukaemia viral oncogene homolog 1 (BCR-ABL), which is responsible for driving the disease through activation of downstream signal transduction pathways. Recent evidence from our group and others indicates that important regulatory networks involved in establishing primitive and definitive haemopoiesis during development are reactivated in myeloid leukaemia, giving rise to an LSC population with altered self-renewal and differentiation properties. In this review, we explore the role the bone morphogenic protein (BMP) signalling plays in stem cell pluripotency, developmental haemopoiesis, HSC maintenance and the implication of altered BMP signalling on LSC persistence in the BM niche. Overall, we emphasise how the BMP and Wnt pathways converge to alter the Cdx–Hox axis and the implications of this in the pathogenesis of myeloid malignancies

A tree formulation for signaling games

We provide a detailed presentation and complete analysis of the sender/receiver Lewis signaling game using a game theory extensive form, decision tree formulation. The analysis employs well established game theory ideas and concepts. We establish the existence of four perfect Bayesian equilibria in this game. We explain which equilibrium is the most likely to prevail. Our explanation provides an essential step for understanding the formation of a language convention. Further, we discuss the informational content of such signals and calibrate a more detailed definition of a true (“correct”) signal in terms of the payoffs of the sender and the receiver

Canonical time-frequency, time-scale, and frequency-scale representations of time-varying channels

Mobile communication channels are often modeled as linear time-varying filters or, equivalently, as time-frequency integral operators with finite support in time and frequency. Such a characterization inherently assumes the signals are narrowband and may not be appropriate for wideband signals. In this paper time-scale characterizations are examined that are useful in wideband time-varying channels, for which a time-scale integral operator is physically justifiable. A review of these time-frequency and time-scale characterizations is presented. Both the time-frequency and time-scale integral operators have a two-dimensional discrete characterization which motivates the design of time-frequency or time-scale rake receivers. These receivers have taps for both time and frequency (or time and scale) shifts of the transmitted signal. A general theory of these characterizations which generates, as specific cases, the discrete time-frequency and time-scale models is presented here. The interpretation of these models, namely, that they can be seen to arise from processing assumptions on the transmit and receive waveforms is discussed. Out of this discussion a third model arises: a frequency-scale continuous channel model with an associated discrete frequency-scale characterization.Comment: To appear in Communications in Information and Systems - special issue in honor of Thomas Kailath's seventieth birthda

Calcium, Orai1, and Epidermal Proliferation

Ca2+ influx controls essential epidermal functions, including proliferation, differentiation, cell migration, itch, and barrier homeostasis. The Orai1 ion channel allows capacitive Ca2+ influx after Ca2+ release from the endoplasmic reticulum, and it has now been shown to modulate epidermal atrophy. These findings reveal new interactions among various Ca2+ signaling pathways and uncover novel functions for Ca2+ signaling via the Orai1 channel

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Bibliography of digitized public domain sources related to flags

Energy Signaling in the Regulation of Gene Expression during Stress

Maintenance of homeostasis is pivotal to all forms of life. In the case of plants, homeostasis is constantly threatened by the inability to escape environmental fluctuations, and therefore sensitive mechanisms must have evolved to allow rapid perception of environmental cues and concomitant modification of growth and developmental patterns for adaptation and survival. Re-establishment of homeostasis in response to environmental perturbations requires reprogramming of metabolism and gene expression to shunt energy sources from growth-related biosynthetic processes to defense, acclimation, and, ultimately, adaptation. Failure to mount an initial 'emergency' response may result in nutrient deprivation and irreversible senescence and cell death. Early signaling events largely determine the capacity of plants to orchestrate a successful adaptive response. Early events, on the other hand, are likely to be shared by different conditions through the generation of similar signals and before more specific responses are elaborated. Recent studies lend credence to this hypothesis, underpinning the importance of a shared energy signal in the transcriptional response to various types of stress. Energy deficiency is associated with most environmental perturbations due to their direct or indirect deleterious impact on photosynthesis and/or respiration. Several systems are known to have evolved for monitoring the available resources and triggering metabolic, growth, and developmental decisions accordingly. In doing so, energy-sensing systems regulate gene expression at multiple levels to allow flexibility in the diversity and the kinetics of the stress response.Marie Curie International Reintegration Grant: PIRG03-GA-2008-231020