Deficit of social cognition in subjects with surgically treated frontal lobe lesions and in subjects affected by schizophrenia

The ability of humans to predict and explain other people’s behaviour by attributing independent mental states such as desires and beliefs to them, is considered to be due to our ability to construct a “Theory of Mind”. Recently, several neuroimaging studies have implicated the medial frontal lobes as playing a critical role in a dedicated “mentalizing” or “Theory of Mind” network in the human brain. In this study we compare the performance of patients with right and left medial prefrontal lobe lesions in theory of mind and in social cognition tasks, with the performance of people with schizophrenia. We report a similar social cognitive profile between patients with prefrontal lobe lesions and schizophrenic subjects in terms of understanding of false beliefs, in understanding social situations and in using tactical strategies. These findings are relevant for the functional anatomy of “Theory of Mind”

Aging, sex and cognitive Theory of Mind: a transcranial direct current stimulation study

Aging is accompanied by changes in cognitive abilities and a great interest is spreading among researchers about aging impact on social cognition skills, such as the Theory of Mind (ToM). Transcranial direct current stimulation (tDCS) has been used in social cognition studies founding evidence of sex-related different effects on cognitive ToM task in a young people sample. In this randomized, double-blind, sham-controlled study, we applied one active and one sham tDCS session on the medial prefrontal cortex (mPFC) during a cognitive ToM task, including both social (i.e., communicative) and nonsocial (i.e., private) intention attribution conditions, in sixty healthy aging individuals (30 males and 30 females). In half of the participants the anode was positioned over the mPFC, whereas in the other half the cathode was positioned over the mPFC. The results showed that: (i) anodal tDCS over the mPFC led to significant slower reaction times (vs. sham) for social intention attribution task only in female participants; (ii) No effects were found in both females and males during cathodal stimulation. We show for the first time sex-related differences in cognitive ToM abilities in healthy aging, extending previous findings concerning young participants

A cross-sectional study to assess pragmatic strengths and weaknesses in healthy ageing

BACKGROUND: Ageing refers to the natural and physiological changes that individuals experience over the years. This process also involves modifications in terms of communicative-pragmatics, namely the ability to convey meanings in social contexts and to interact with other people using various expressive means, such as linguistic, extralinguistic and paralinguistic aspects of communication. Very few studies have provided a complete assessment of communicative-pragmatic performance in healthy ageing. METHODS: The aim of this study was to comprehensively assess communicative-pragmatic ability in three samples of 20 (N = 60) healthy adults, each belonging to a different age range (20–40, 65–75, 76–86 years old) and to compare their performance in order to observe any potential changes in their ability to communicate. We also explored the potential role of education and sex on the communicative-pragmatic abilities observed. The three age groups were evaluated with a between-study design by means of the Assessment Battery for Communication (ABaCo), a validated assessment tool characterised by five scales: linguistic, extralinguistic, paralinguistic, contextual and conversational. RESULTS: The results indicated that the pragmatic ability assessed by the ABaCo is poorer in older participants when compared to the younger ones (main effect of age group: F(2,56) = 9.097; p < .001). Specifically, significant differences were detected in tasks on the extralinguistic, paralinguistic and contextual scales. Whereas the data highlighted a significant role of education (F(1,56) = 4.713; p = .034), no sex-related differences were detected. CONCLUSIONS: Our results suggest that the ageing process may also affect communicative-pragmatic ability and a comprehensive assessment of the components of such ability may help to better identify difficulties often experienced by older individuals in their daily life activities. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-03304-z

Fitting Pragmatics into the Human Mind: A philosophical investigation of the Pragmatics Module Hypothesis

This thesis focuses on the hypothesis that pragmatic understanding is underpinned by a mental module closely related to the ability to interpret others’ behaviors by inferring underlying mental states, also called ‘mindreading’. First, it aims at evaluating the plausibility of this hypothesis in light of the available data in the empirical literature by drawing on the argumentative toolbox of the philosophy of mind and language. Second, it aims at developing this hypothesis by addressing its main theoretical and empirical challenges. In Chapter One, I outline a historical overview of the different declinations of the modularity hypothesis in cognitive science, with a focus on early works in cognitive pragmatics and Theory of Mind research. In Chapter Two, I provide a comprehensive theoretical analysis of the Pragmatics Module Hypothesis by focusing on the central tenets of Relevance Theory. In Chapter Three, I explore the idea of pragmatics as a ‘sub-module’ of Theory of Mind from an empirical perspective by surveying the current state of the art in experimental and clinical pragmatics, thus ‘clearing up’ the recent controversy on the modularity of pragmatics from some misconceptions and empirical predictions which do not follow from the Pragmatics Module Hypothesis. In Chapter Four, I provide a novel cognitive framework for the modular view of pragmatics by evaluating the significance of research on ostensive communication in infancy with respect to the hypothesis of an early-developing modular heuristic for interpreting communicative behaviors. Chapters Five and Six both focus on the several ‘developmental dilemmas’ that must be confronted by intentional-inferential accounts of infant communication like the one endorsed in the present thesis, which will be disentangled, analyzed, and addressed by evaluating several possible solutions. In these two chapters, I show how the cognitive framework offered in Chapter Four can be employed and further extended to deal with such developmental dilemmas from a renewed modular perspective

Social Cognition in Children with Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, which impacts behavioral outcomes, including social functioning. Children with ADHD demonstrate impairment across a number of social domains, including aggressive behavior, poor social skills, and higher rates of Oppositional Defiant Disorder compared to typically developing peers. However, the underlying neurocognitive underpinnings of these poor social outcomes are unclear. Furthermore, little is known regarding the impact of ADHD symptomatology on aspects of social cognition. Inattention, hyperactivity, and impulsivity may differentially impact components of social cognition. Determining whether performance on social cognition tasks is predictive of social skills and problem behaviors is also an area with limited research. Therefore, the current study investigated the relationship between behavioral outcomes, social cognition, and ADHD symptomatology. Children with ADHD performed significantly poorer than the control group on measures of affect recognition, pragmatic language, cognitive theory of mind (ToM), and cognitive empathy. Inattention was predictive of performance in these domains, but there was little improvement of the model with the addition of hyperactivity and impulsivity. Pragmatic language, cognitive ToM, and cognitive empathy were predictive of parent ratings of problem and prosocial behaviors. Findings indicate that children with ADHD have difficulty with cognitive, but not affective components of social cognition

Over-reliance on English hinders cognitive science

English is the dominant language in the study of human cognition and behavior: the individuals studied by cognitive scientists, as well as most of the scientists themselves, are frequently English speakers. However, English differs from other languages in ways that have consequences for the whole of the cognitive sciences, reaching far beyond the study of language itself. Here, we review an emerging body of evidence that highlights how the particular characteristics of English and the linguistic habits of English speakers bias the field by both warping research programs (e.g., overemphasizing features and mechanisms present in English over others) and overgeneralizing observations from English speakers’ behaviors, brains, and cognition to our entire species. We propose mitigating strategies that could help avoid some of these pitfalls

Pragmatics, Theory of Mind and executive functions in schizophrenia: Disentangling the puzzle using machine learning

OBJECTIVE:Schizophrenia is associated with a severe impairment in the communicative-pragmatic domain. Recent research has tried to disentangle the relationship between communicative impairment and other domains usually impaired in schizophrenia, i.e. Theory of Mind (ToM) and cognitive functions. However, the results are inconclusive and this relationship is still unclear. Machine learning (ML) provides novel opportunities for studying complex relationships among phenomena and representing causality among multiple variables. The present research explored the potential of applying ML, specifically Bayesian network (BNs) analysis, to characterize the relationship between cognitive, ToM and pragmatic abilities in individuals with schizophrenia and healthy controls, and to identify the cognitive and pragmatic abilities that are most informative in discriminating between schizophrenia and controls. METHODS:We provided a comprehensive assessment of different aspects of pragmatic performance, i.e. linguistic, extralinguistic, paralinguistic, contextual and conversational, ToM and cognitive functions, i.e. Executive Functions (EF)-selective attention, planning, inhibition, cognitive flexibility, working memory and speed processing-and general intelligence, in a sample of 32 individuals with schizophrenia and 35 controls. RESULTS:The results showed that the BNs classifier discriminated well between patients with schizophrenia and healthy controls. The network structure revealed that only pragmatic Linguistic ability directly influenced the classification of patients and controls, while diagnosis determined performance on ToM, Extralinguistic, Paralinguistic, Selective Attention, Planning, Inhibition and Cognitive Flexibility tasks. The model identified pragmatic, ToM and cognitive abilities as three distinct domains independent of one another. CONCLUSION:Taken together, our results confirmed the importance of considering pragmatic linguistic impairment as a core dysfunction in schizophrenia, and demonstrated the potential of applying BNs in investigating the relationship between pragmatic ability and cognition

Frontotemporal dementia, music perception and social cognition share neurobiological circuits:A meta-analysis

Frontotemporal dementia (FTD) is a neurodegenerative disease that presents with profound changes in social cognition. Music might be a sensitive probe for social cognition abilities, but underlying neurobiological substrates are unclear. We performed a meta-analysis of voxel-based morphometry studies in FTD patients and functional MRI studies for music perception and social cognition tasks in cognitively normal controls to identify robust patterns of atrophy (FTD) or activation (music perception or social cognition). Conjunction analyses were performed to identify overlapping brain regions. In total 303 articles were included: 53 for FTD (n = 1153 patients, 42.5% female; 1337 controls, 53.8% female), 28 for music perception (n = 540, 51.8% female) and 222 for social cognition in controls (n = 5664, 50.2% female). We observed considerable overlap in atrophy patterns associated with FTD, and functional activation associated with music perception and social cognition, mostly encompassing the ventral language network. We further observed overlap across all three modalities in mesolimbic, basal forebrain and striatal regions. The results of our meta-analysis suggest that music perception and social cognition share neurobiological circuits that are affected in FTD. This supports the idea that music might be a sensitive probe for social cognition abilities with implications for diagnosis and monitoring