CoAKTinG: Collaborative Advanced Knowledge Technologies in the Grid

Grid infrastructures coupled with semantic web linkage and reasoning open up intriguing new possibilities for scientific collaboration. In this short paper, we outline the research agenda and collaboration technologies under development within the CoAKTinG project: Collaborative Advanced Knowledge Technologies in the Grid. CoAKTinG will provide tools to assist scientific collaboration by integrating intelligent meeting spaces, ontologically annotated media streams from online meetings, decision rationale and group memory capture, meeting facilitation, issue handling, planning and coordination support, constraint satisfaction, and instant messaging/presence. Their integration is illustrated through an extended use scenario

The Units Ontology: a tool for integrating units of measurement in science

Units are basic scientific tools that render meaning to numerical data. Their standardization and formalization caters for the report, exchange, process, reproducibility and integration of quantitative measurements. Ontologies are means that facilitate the integration of data and knowledge allowing interoperability and semantic information processing between diverse biomedical resources and domains. Here, we present the Units Ontology (UO), an ontology currently being used in many scientific resources for the standardized description of units of measurements

The Form of Organization for Small Business

Matching and integrating ontologies has been a desirable technique in areas such as data fusion, knowledge integration, the Semantic Web and the development of advanced services in distributed system. Unfortunately, the heterogeneities of ontologies cause big obstacles in the development of this technique. This licentiate thesis describes an approach to tackle the problem of ontology integration using description logics and production rules, both on a syntactic level and on a semantic level. Concepts in ontologies are matched and integrated to generate ontology intersections. Context is extracted and rules for handling heterogeneous ontology reasoning with contexts are developed. Ontologies are integrated by two processes. The first integration is to generate an ontology intersection from two OWL ontologies. The result is an ontology intersection, which is an independent ontology containing non-contradictory assertions based on the original ontologies. The second integration is carried out by rules that extract context, such as ontology content and ontology description data, e.g. time and ontology creator. The integration is designed for conceptual ontology integration. The information of instances isn't considered, neither in the integrating process nor in the integrating results. An ontology reasoner is used in the integration process for non-violation check of two OWL ontologies and a rule engine for handling conflicts according to production rules. The ontology reasoner checks the satisfiability of concepts with the help of anchors, i.e. synonyms and string-identical entities; production rules are applied to integrate ontologies, with the constraint that the original ontologies should not be violated. The second integration process is carried out with production rules with context data of the ontologies. Ontology reasoning, in a repository, is conducted within the boundary of each ontology. Nonetheless, with context rules, reasoning is carried out across ontologies. The contents of an ontology provide context for its defined entities and are extracted to provide context with the help of an ontology reasoner. Metadata of ontologies are criteria that are useful for describing ontologies. Rules using context, also called context rules, are developed and in-built in the repository. New rules can also be added. The scientific contribution of the thesis is the suggested approach applying semantic based techniques to provide a complementary method for ontology matching and integrating semantically. With the illustration of the ontology integration process and the context rules and a few manually integrated ontology results, the approach shows the potential to help to develop advanced knowledge-based services.QC 20130201</p

e-Science and biological pathway semantics

<p>Abstract</p> <p>Background</p> <p>The development of e-Science presents a major set of opportunities and challenges for the future progress of biological and life scientific research. Major new tools are required and corresponding demands are placed on the high-throughput data generated and used in these processes. Nowhere is the demand greater than in the semantic integration of these data. Semantic Web tools and technologies afford the chance to achieve this semantic integration. Since pathway knowledge is central to much of the scientific research today it is a good test-bed for semantic integration. Within the context of biological pathways, the BioPAX initiative, part of a broader movement towards the standardization and integration of life science databases, forms a necessary prerequisite for its successful application of e-Science in health care and life science research. This paper examines whether BioPAX, an effort to overcome the barrier of disparate and heterogeneous pathway data sources, addresses the needs of e-Science.</p> <p>Results</p> <p>We demonstrate how BioPAX pathway data can be used to ask and answer some useful biological questions. We find that BioPAX comes close to meeting a broad range of e-Science needs, but certain semantic weaknesses mean that these goals are missed. We make a series of recommendations for re-modeling some aspects of BioPAX to better meet these needs.</p> <p>Conclusion</p> <p>Once these semantic weaknesses are addressed, it will be possible to integrate pathway information in a manner that would be useful in e-Science.</p

Towards Semantic e-Science for Traditional Chinese Medicine

<p>Abstract</p> <p>Background</p> <p>Recent advances in Web and information technologies with the increasing decentralization of organizational structures have resulted in massive amounts of information resources and domain-specific services in Traditional Chinese Medicine. The massive volume and diversity of information and services available have made it difficult to achieve seamless and interoperable e-Science for knowledge-intensive disciplines like TCM. Therefore, information integration and service coordination are two major challenges in e-Science for TCM. We still lack sophisticated approaches to integrate scientific data and services for TCM e-Science.</p> <p>Results</p> <p>We present a comprehensive approach to build dynamic and extendable e-Science applications for knowledge-intensive disciplines like TCM based on semantic and knowledge-based techniques. The semantic e-Science infrastructure for TCM supports large-scale database integration and service coordination in a virtual organization. We use domain ontologies to integrate TCM database resources and services in a semantic cyberspace and deliver a semantically superior experience including browsing, searching, querying and knowledge discovering to users. We have developed a collection of semantic-based toolkits to facilitate TCM scientists and researchers in information sharing and collaborative research.</p> <p>Conclusion</p> <p>Semantic and knowledge-based techniques are suitable to knowledge-intensive disciplines like TCM. It's possible to build on-demand e-Science system for TCM based on existing semantic and knowledge-based techniques. The presented approach in the paper integrates heterogeneous distributed TCM databases and services, and provides scientists with semantically superior experience to support collaborative research in TCM discipline.</p

The New Ontologies: The Effect of Copyright Protection on Public Scientific Data Sharing Using Semantic Web Ontologies, 10 J. Marshall Rev. Intell. Prop. L. 181 (2010)

The semantic web is going to become an important tool for scientists who need to accurately share data given context through structured relationships. The structure that defines contextual relationships on the semantic web is known as an ontology; which is a hierarchical organization of a knowledge domain that contains entities and their relations. This paper seeks to answer whether semantic web ontologies are protectable by copyright, and regardless of the outcome, what the best practices are for the scientific community. The best practices for the scientific community should include the adoption of a machine readable ontology license which disclaims copyright protection for publication of public scientific data to assure automation of the integration of ontologies and to maximize easy access to public science materials that can be queried. Sharing and information is essential for scientists and failure to address the possibility of ontologies as a possible constraint to public data access could result in data fragmentation and lost scientific opportunities. The ability of the semantic web to annotate and reuse data relies on the social structure of science supporting data sharing as a norm and as an extension of this norm, open licensing of ontologies should be embraced

RegenBase: a knowledge base of spinal cord injury biology for translational research.

Spinal cord injury (SCI) research is a data-rich field that aims to identify the biological mechanisms resulting in loss of function and mobility after SCI, as well as develop therapies that promote recovery after injury. SCI experimental methods, data and domain knowledge are locked in the largely unstructured text of scientific publications, making large scale integration with existing bioinformatics resources and subsequent analysis infeasible. The lack of standard reporting for experiment variables and results also makes experiment replicability a significant challenge. To address these challenges, we have developed RegenBase, a knowledge base of SCI biology. RegenBase integrates curated literature-sourced facts and experimental details, raw assay data profiling the effect of compounds on enzyme activity and cell growth, and structured SCI domain knowledge in the form of the first ontology for SCI, using Semantic Web representation languages and frameworks. RegenBase uses consistent identifier schemes and data representations that enable automated linking among RegenBase statements and also to other biological databases and electronic resources. By querying RegenBase, we have identified novel biological hypotheses linking the effects of perturbagens to observed behavioral outcomes after SCI. RegenBase is publicly available for browsing, querying and download.Database URL:http://regenbase.org

Applications and Uses of Dental Ontologies

The development of a number of large-scale semantically-rich ontologies for biomedicine attests to the interest of life science researchers and clinicians in Semantic Web technologies. To date, however, the dental profession has lagged behind other areas of biomedicine in developing a commonly accepted, standardized ontology to support the representation of dental knowledge and information. This paper attempts to identify some of the potential uses of dental ontologies as part of an effort to motivate the development of ontologies for the dental domain. The identified uses of dental ontologies include support for advanced data analysis and knowledge discovery capabilities, the implementation of novel education and training technologies, the development of information exchange and interoperability solutions, the better integration of scientific and clinical evidence into clinical decision-making, and the development of better clinical decision support systems. Some of the social issues raised by these uses include the ethics of using patient data without consent, the role played by ontologies in enforcing compliance with regulatory criteria and legislative constraints, and the extent to which the advent of the Semantic Web introduces new training requirements for dental students. Some of the technological issues relate to the need to extract information from a variety of resources (for example, natural language texts), the need to automatically annotate information resources with ontology elements, and the need to establish mappings between a variety of existing dental terminologies