A Rapid Segmentation-Insensitive "Digital Biopsy" Method for Radiomic Feature Extraction: Method and Pilot Study Using CT Images of Non-Small Cell Lung Cancer.

Quantitative imaging approaches compute features within images' regions of interest. Segmentation is rarely completely automatic, requiring time-consuming editing by experts. We propose a new paradigm, called "digital biopsy," that allows for the collection of intensity- and texture-based features from these regions at least 1 order of magnitude faster than the current manual or semiautomated methods. A radiologist reviewed automated segmentations of lung nodules from 100 preoperative volume computed tomography scans of patients with non-small cell lung cancer, and manually adjusted the nodule boundaries in each section, to be used as a reference standard, requiring up to 45 minutes per nodule. We also asked a different expert to generate a digital biopsy for each patient using a paintbrush tool to paint a contiguous region of each tumor over multiple cross-sections, a procedure that required an average of <3 minutes per nodule. We simulated additional digital biopsies using morphological procedures. Finally, we compared the features extracted from these digital biopsies with our reference standard using intraclass correlation coefficient (ICC) to characterize robustness. Comparing the reference standard segmentations to our digital biopsies, we found that 84/94 features had an ICC >0.7; comparing erosions and dilations, using a sphere of 1.5-mm radius, of our digital biopsies to the reference standard segmentations resulted in 41/94 and 53/94 features, respectively, with ICCs >0.7. We conclude that many intensity- and texture-based features remain consistent between the reference standard and our method while substantially reducing the amount of operator time required

Object-based assessment of tree attributes of Acacia tortilis in Bou-Hedma, Tunisia

Acacia tortilis subsp. raddiana represents the most important woody species in the pre-Saharan zone. It is the only forest tree persisting on the edge of the desert. Due to tree/environment interactions, canopy sub-habitats arise, enabling an increased storage of soil water, soil nutrients and soil oxygen. Depending on their density, they can also reduce erosion and reverse desertification. Soil erosion and desertification are the main problems faced by the UNESCO Biosphere Reserve in South-Tunisia (Bou-Hedma National Park). The restoration of the original woodland cover to combat desertification (particularly) by afforestation and reforestation of Acacia tortilis goes hand in hand with a climate change in the Biosphere Reserve, also influencing rural population outside the Biosphere Reserve. In order to study the different effects of woodland restoration in Bou-Hedma, the number of Acacia trees and their attributes have to be known. High resolution satellite imagery (GeoEye-1), was used with a GEOBIA approach. Field measurement of bole diameter, crown diameter and tree height were collected at > 400 locations. After segmentation, correlations with > 200 object features and tree attributes were calculated. For crown diameter and tree height, high correlations were observed with the features area and GLCM Entropy Layer 4 (90 degrees). Relations between these features and measured tree attributes were modeled, resulting in RMSE values of resp. 1.47 m and 1.62 m for crown diameter estimation and 0.92 m for tree height. The results show that a GEOBIA working strategy is suitable for estimating tree attributes in open forests in semi-arid regions

Region-based segmentation of images using syntactic visual features

This paper presents a robust and efficient method for segmentation of images into large regions that reflect the real world objects present in the scene. We propose an extension to the well known Recursive Shortest Spanning Tree (RSST) algorithm based on a new color model and so-called syntactic features [1]. We introduce practical solutions, integrated within the RSST framework, to structure analysis based on the shape and spatial configuration of image regions. We demonstrate that syntactic features provide a reliable basis for region merging criteria which prevent formation of regions spanning more than one semantic object, thereby significantly improving the perceptual quality of the output segmentation. Experiments indicate that the proposed features are generic in nature and allow satisfactory segmentation of real world images from various sources without adjustment to algorithm parameters

Why pitch sensitivity matters : event-related potential evidence of metric and syntactic violation detection among spanish late learners of german

Event-related potential (ERP) data in monolingual German speakers have shown that sentential metric expectancy violations elicit a biphasic ERP pattern consisting of an anterior negativity and a posterior positivity (P600). This pattern is comparable to that elicited by syntactic violations. However, proficient French late learners of German do not detect violations of metric expectancy in German. They also show qualitatively and quantitatively different ERP responses to metric and syntactic violations. We followed up the questions whether (1) latter evidence results from a potential pitch cue insensitivity in speech segmentation in French speakers, or (2) if the result is founded in rhythmic language differences. Therefore, we tested Spanish late learners of German, as Spanish, contrary to French, uses pitch as a segmentation cue even though the basic segmentation unit is the same in French and Spanish (i.e., the syllable). We report ERP responses showing that Spanish L2 learners are sensitive to syntactic as well as metric violations in German sentences independent of attention to task in a P600 response. Overall, the behavioral performance resembles that of German native speakers. The current data suggest that Spanish L2 learners are able to extract metric units (trochee) in their L2 (German) even though their basic segmentation unit in Spanish is the syllable. In addition Spanish in contrast to French L2 learners of German are sensitive to syntactic violations indicating a tight link between syntactic and metric competence. This finding emphasizes the relevant role of metric cues not only in L2 prosodic but also in syntactic processing