Weak signal identification with semantic web mining

We investigate an automated identification of weak signals according to Ansoff to improve strategic planning and technological forecasting. Literature shows that weak signals can be found in the organization's environment and that they appear in different contexts. We use internet information to represent organization's environment and we select these websites that are related to a given hypothesis. In contrast to related research, a methodology is provided that uses latent semantic indexing (LSI) for the identification of weak signals. This improves existing knowledge based approaches because LSI considers the aspects of meaning and thus, it is able to identify similar textual patterns in different contexts. A new weak signal maximization approach is introduced that replaces the commonly used prediction modeling approach in LSI. It enables to calculate the largest number of relevant weak signals represented by singular value decomposition (SVD) dimensions. A case study identifies and analyses weak signals to predict trends in the field of on-site medical oxygen production. This supports the planning of research and development (R&D) for a medical oxygen supplier. As a result, it is shown that the proposed methodology enables organizations to identify weak signals from the internet for a given hypothesis. This helps strategic planners to react ahead of time

Using webcrawling of publicly available websites to assess E-commerce relationships

We investigate e-commerce success factors concerning their impact on the success of commerce transactions between businesses companies. In scientific literature, many e-commerce success factors are introduced. Most of them are focused on companies' website quality. They are evaluated concerning companies' success in the business-to- consumer (B2C) environment where consumers choose their preferred e-commerce websites based on these success factors e.g. website content quality, website interaction, and website customization. In contrast to previous work, this research focuses on the usage of existing e-commerce success factors for predicting successfulness of business-to-business (B2B) ecommerce. The introduced methodology is based on the identification of semantic textual patterns representing success factors from the websites of B2B companies. The successfulness of the identified success factors in B2B ecommerce is evaluated by regression modeling. As a result, it is shown that some B2C e-commerce success factors also enable the predicting of B2B e-commerce success while others do not. This contributes to the existing literature concerning ecommerce success factors. Further, these findings are valuable for B2B e-commerce websites creation

Locally-Stable Macromodels of Integrated Digital Devices for Multimedia Applications

This paper addresses the development of accurate and efficient behavioral models of digital integrated circuits for the assessment of high-speed systems. Device models are based on suitable parametric expressions estimated from port transient responses and are effective at system level, where the quality of functional signals and the impact of supply noise need to be simulated. A potential limitation of some state-of-the-art modeling techniques resides in hidden instabilities manifesting themselves in the use of models, without being evident in the building phase of the same models. This contribution compares three recently-proposed model structures, and selects the local-linear state-space modeling technique as an optimal candidate for the signal integrity assessment of data links. In fact, this technique combines a simple verification of the local stability of models with a limited model size and an easy implementation in commercial simulation tools. An application of the proposed methodology to a real problem involving commercial devices and a data-link of a wireless device demonstrates the validity of this approac

Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy

Circular RNAs (circRNAs) may act as novel cancer biomarkers. However, a genome-wide evaluation of circRNAs in clear cell renal cell carcinoma (ccRCC) has yet to be conducted. Therefore, the objective of this study was to identify and validate circRNAs in ccRCC tissue with a focus to evaluate their potential as prognostic biomarkers. A genome-wide identification of circRNAs in total RNA extracted from ccRCC tissue samples was performed using microarray analysis. Three relevant differentially expressed circRNAs were selected (circEGLN3, circNOX4, and circRHOBTB3), their circular nature was experimentally confirmed, and their expression-along with that of their linear counterparts-was measured in 99 malignant and 85 adjacent normal tissue samples using specifically established RT-qPCR assays. The capacity of circRNAs to discriminate between malignant and adjacent normal tissue samples and their prognostic potential (with the endpoints cancer-specific, recurrence-free, and overall survival) after surgery were estimated by C-statistics, Kaplan-Meier method, univariate and multivariate Cox regression analysis, decision curve analysis, and Akaike and Bayesian information criteria. CircEGLN3 discriminated malignant from normal tissue with 97% accuracy. We generated a prognostic for the three endpoints by multivariate Cox regression analysis that included circEGLN3, circRHOBT3 and linRHOBTB3. The predictive outcome accuracy of the clinical models based on clinicopathological factors was improved in combination with this circRNA-based signature. Bootstrapping as well as Akaike and Bayesian information criteria confirmed the statistical significance and robustness of the combined models. Limitations of this study include its retrospective nature and the lack of external validation. The study demonstrated the promising potential of circRNAs as diagnostic and particularly prognostic biomarkers in ccRCC patients

Techno-economic projections for advanced small solar thermal electric power plants to years 1990-2000

Advanced technologies applicable to solar thermal electric power systems in the 1990-200 time-frame are delineated for power applications that fulfill a wide spectrum of small power needs with primary emphasis on power ratings less than 10MWe. Projections of power system characteristics (energy and capital costs as a function of capacity factor) are made based on development of identified promising technologies and are used as the basis for comparing technology development options and combinations of these options to determine developmental directions offering potential for significant improvements. Stirling engines, Brayton/Rankine combined cycles and storage/transport concepts encompassing liquid metals, and reversible-reaction chemical systems are considered for two-axis tracking systems such as the central receiver or power tower concept and distributed parabolic dish receivers which can provide efficient low-cost solar energy collection while achieving high temperatures for efficient energy conversion. Pursuit of advanced technology across a broad front can result in post-1985 solar thermal systems having the potential of approaching the goal of competitiveness with conventional power systems