Retrospective on high-level language computer architecture

High-level language computers (HLLC) have attracted interest in the architectural and programming community during the last 15 years; proposals have been made for machines directed towards the execution of various languages such as ALGOL, 1,2 APL, 3,4,5 BASIC, 6.

Evaluating Software Architectures: Development Stability and Evolution

We survey seminal work on software architecture evaluationmethods. We then look at an emerging class of methodsthat explicates evaluating software architectures forstability and evolution. We define architectural stabilityand formulate the problem of evaluating software architecturesfor stability and evolution. We draw the attention onthe use of Architectures Description Languages (ADLs) forsupporting the evaluation of software architectures in generaland for architectural stability in specific

Industry-scale application and evaluation of deep learning for drug target prediction

Artificial intelligence (AI) is undergoing a revolution thanks to the breakthroughs of machine learning algorithms in computer vision, speech recognition, natural language processing and generative modelling. Recent works on publicly available pharmaceutical data showed that AI methods are highly promising for Drug Target prediction. However, the quality of public data might be different than that of industry data due to different labs reporting measurements, different measurement techniques, fewer samples and less diverse and specialized assays. As part of a European funded project (ExCAPE), that brought together expertise from pharmaceutical industry, machine learning, and high-performance computing, we investigated how well machine learning models obtained from public data can be transferred to internal pharmaceutical industry data. Our results show that machine learning models trained on public data can indeed maintain their predictive power to a large degree when applied to industry data. Moreover, we observed that deep learning derived machine learning models outperformed comparable models, which were trained by other machine learning algorithms, when applied to internal pharmaceutical company datasets. To our knowledge, this is the first large-scale study evaluating the potential of machine learning and especially deep learning directly at the level of industry-scale settings and moreover investigating the transferability of publicly learned target prediction models towards industrial bioactivity prediction pipelines.Web of Science121art. no. 2

Retrospective Reader for Machine Reading Comprehension

Machine reading comprehension (MRC) is an AI challenge that requires machine to determine the correct answers to questions based on a given passage. MRC systems must not only answer question when necessary but also distinguish when no answer is available according to the given passage and then tactfully abstain from answering. When unanswerable questions are involved in the MRC task, an essential verification module called verifier is especially required in addition to the encoder, though the latest practice on MRC modeling still most benefits from adopting well pre-trained language models as the encoder block by only focusing on the "reading". This paper devotes itself to exploring better verifier design for the MRC task with unanswerable questions. Inspired by how humans solve reading comprehension questions, we proposed a retrospective reader (Retro-Reader) that integrates two stages of reading and verification strategies: 1) sketchy reading that briefly investigates the overall interactions of passage and question, and yield an initial judgment; 2) intensive reading that verifies the answer and gives the final prediction. The proposed reader is evaluated on two benchmark MRC challenge datasets SQuAD2.0 and NewsQA, achieving new state-of-the-art results. Significance tests show that our model is significantly better than the strong ELECTRA and ALBERT baselines. A series of analysis is also conducted to interpret the effectiveness of the proposed reader.Comment: Accepted by AAAI 202

Formalising responsibility modelling for automatic analysis

Modelling the structure of social-technical systems as a basis for informing software system design is a difficult compromise. Formal methods struggle to capture the scale and complexity of the heterogeneous organisations that use technical systems. Conversely, informal approaches lack the rigour needed to inform the software design and construction process or enable automated analysis. We revisit the concept of responsibility modelling, which models social technical systems as a collection of actors who discharge their responsibilities, whilst using and producing resources in the process. Responsibility modelling is formalised as a structured approach for socio-technical system requirements specification and modelling, with well-defined semantics and support for automated structure and validity analysis. The effectiveness of the approach is demonstrated by two case studies of software engineering methodologies

Special Libraries, December 1975

Volume 66, Issue 12https://scholarworks.sjsu.edu/sla_sl_1975/1009/thumbnail.jp