Quality of Service over Specific Link Layers: state of the art report

The Integrated Services concept is proposed as an enhancement to the current Internet architecture, to provide a better Quality of Service (QoS) than that provided by the traditional Best-Effort service. The features of the Integrated Services are explained in this report. To support Integrated Services, certain requirements are posed on the underlying link layer. These requirements are studied by the Integrated Services over Specific Link Layers (ISSLL) IETF working group. The status of this ongoing research is reported in this document. To be more specific, the solutions to provide Integrated Services over ATM, IEEE 802 LAN technologies and low-bitrate links are evaluated in detail. The ISSLL working group has not yet studied the requirements, that are posed on the underlying link layer, when this link layer is wireless. Therefore, this state of the art report is extended with an identification of the requirements that are posed on the underlying wireless link, to provide differentiated Quality of Service

Performance of voice and video conferencing over ATM and gigabit ethernet backbone networks

Gigabit Ethernet and ATM network technologies have been modeled as campus network backbones for the simulation-based comparison of their performance. Real-time voice and video conferencing traffic is used to compare the performance of both backbone technologies in terms of response times and packet end-to-end delays. Simulation results show that Gigabit Ethernet has been able to perform the same and in some cases better than ATM as a backbone network for video and voice conferencing providing network designers with a cheaper solution to meet the growing needs of bandwidth-hungry applications in a campus environment

Molecular Network Control Through Boolean Canalization

Boolean networks are an important class of computational models for molecular interaction networks. Boolean canalization, a type of hierarchical clustering of the inputs of a Boolean function, has been extensively studied in the context of network modeling where each layer of canalization adds a degree of stability in the dynamics of the network. Recently, dynamic network control approaches have been used for the design of new therapeutic interventions and for other applications such as stem cell reprogramming. This work studies the role of canalization in the control of Boolean molecular networks. It provides a method for identifying the potential edges to control in the wiring diagram of a network for avoiding undesirable state transitions. The method is based on identifying appropriate input-output combinations on undesirable transitions that can be modified using the edges in the wiring diagram of the network. Moreover, a method for estimating the number of changed transitions in the state space of the system as a result of an edge deletion in the wiring diagram is presented. The control methods of this paper were applied to a mutated cell-cycle model and to a p53-mdm2 model to identify potential control targets

Adaptive Multicast of Multi-Layered Video: Rate-Based and Credit-Based Approaches

Network architectures that can efficiently transport high quality, multicast video are rapidly becoming a basic requirement of emerging multimedia applications. The main problem complicating multicast video transport is variation in network bandwidth constraints. An attractive solution to this problem is to use an adaptive, multi-layered video encoding mechanism. In this paper, we consider two such mechanisms for the support of video multicast; one is a rate-based mechanism that relies on explicit rate congestion feedback from the network, and the other is a credit-based mechanism that relies on hop-by-hop congestion feedback. The responsiveness, bandwidth utilization, scalability and fairness of the two mechanisms are evaluated through simulations. Results suggest that while the two mechanisms exhibit performance trade-offs, both are capable of providing a high quality video service in the presence of varying bandwidth constraints.Comment: 11 page

Energy-efficient wireless communication

In this chapter we present an energy-efficient highly adaptive network interface architecture and a novel data link layer protocol for wireless networks that provides Quality of Service (QoS) support for diverse traffic types. Due to the dynamic nature of wireless networks, adaptations in bandwidth scheduling and error control are necessary to achieve energy efficiency and an acceptable quality of service. In our approach we apply adaptability through all layers of the protocol stack, and provide feedback to the applications. In this way the applications can adapt the data streams, and the network protocols can adapt the communication parameters

The Role of Responsive Pricing in the Internet

The Internet continues to evolve as it reaches out to a wider user population. The recent introduction of user-friendly navigation and retrieval tools for the World Wide Web has triggered an unprecedented level of interest in the Internet among the media and the general public, as well as in the technical community. It seems inevitable that some changes or additions are needed in the control mechanisms used to allocate usage of Internet resources. In this paper, we argue that a feedback signal in the form of a variable price for network service is a workable tool to aid network operators in controlling Internet traffic. We suggest that these prices should vary dynamically based on the current utilization of network resources. We show how this responsive pricing puts control of network service back where it belongs: with the users.Internet, pricing, feedback, networks

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

The DNA Damage Response (DDR) pathway represents a signalling mechanism that is activated in eukaryotic cells following DNA damage and comprises of proteins involved in DNA damage detection, DNA repair, cell cycle arrest and apoptosis. This pathway consists of an intricate network of signalling interactions driving the cellular ability to recognise DNA damage and recruit specialised proteins to take decisions between DNA repair or apoptosis. ATM and ATR are central components of the DDR pathway. The activities of these kinases are vital in DNA damage induced phosphorylational induction of DDR substrates. Here, firstly we have experimentally determined DDR signalling network surrounding the ATM/ATR pathway induced following double stranded DNA damage by monitoring and quantifying time dependent inductions of their phosphorylated forms and their key substrates. We next involved an automated inference of unsupervised predictive models of time series data to generate in silico (molecular) interaction maps. We characterized the complex signalling network through system analysis and gradual utilisation of small time series measurements of key substrates through a novel network inference algorithm. Furthermore, we demonstrate an application of an assumption-free reverse engineering of the intricate signalling network of the activated ATM/ATR pathway. We next studied the consequences of such drug induced inductions as well as of time dependent ATM kinase inhibition on cell survival through further biological experiments. Intermediate and temporal modelling outcomes revealed the distinct signaling profile associated with ATM kinase activity and inhibition and explained the underlying signalling mechanism for dual ATM functionality in cytotoxic and cytoprotective pathways