A Comprehensive Bibliometric Analysis on Social Network Anonymization: Current Approaches and Future Directions

In recent decades, social network anonymization has become a crucial research field due to its pivotal role in preserving users' privacy. However, the high diversity of approaches introduced in relevant studies poses a challenge to gaining a profound understanding of the field. In response to this, the current study presents an exhaustive and well-structured bibliometric analysis of the social network anonymization field. To begin our research, related studies from the period of 2007-2022 were collected from the Scopus Database then pre-processed. Following this, the VOSviewer was used to visualize the network of authors' keywords. Subsequently, extensive statistical and network analyses were performed to identify the most prominent keywords and trending topics. Additionally, the application of co-word analysis through SciMAT and the Alluvial diagram allowed us to explore the themes of social network anonymization and scrutinize their evolution over time. These analyses culminated in an innovative taxonomy of the existing approaches and anticipation of potential trends in this domain. To the best of our knowledge, this is the first bibliometric analysis in the social network anonymization field, which offers a deeper understanding of the current state and an insightful roadmap for future research in this domain.Comment: 73 pages, 28 figure

Network-Based Biomarker Discovery : Development of Prognostic Biomarkers for Personalized Medicine by Integrating Data and Prior Knowledge

Advances in genome science and technology offer a deeper understanding of biology while at the same time improving the practice of medicine. The expression profiling of some diseases, such as cancer, allows for identifying marker genes, which could be able to diagnose a disease or predict future disease outcomes. Marker genes (biomarkers) are selected by scoring how well their expression levels can discriminate between different classes of disease or between groups of patients with different clinical outcome (e.g. therapy response, survival time, etc.). A current challenge is to identify new markers that are directly related to the underlying disease mechanism

Element-centric clustering comparison unifies overlaps and hierarchy

Clustering is one of the most universal approaches for understanding complex data. A pivotal aspect of clustering analysis is quantitatively comparing clusterings; clustering comparison is the basis for many tasks such as clustering evaluation, consensus clustering, and tracking the temporal evolution of clusters. In particular, the extrinsic evaluation of clustering methods requires comparing the uncovered clusterings to planted clusterings or known metadata. Yet, as we demonstrate, existing clustering comparison measures have critical biases which undermine their usefulness, and no measure accommodates both overlapping and hierarchical clusterings. Here we unify the comparison of disjoint, overlapping, and hierarchically structured clusterings by proposing a new element-centric framework: elements are compared based on the relationships induced by the cluster structure, as opposed to the traditional cluster-centric philosophy. We demonstrate that, in contrast to standard clustering similarity measures, our framework does not suffer from critical biases and naturally provides unique insights into how the clusterings differ. We illustrate the strengths of our framework by revealing new insights into the organization of clusters in two applications: the improved classification of schizophrenia based on the overlapping and hierarchical community structure of fMRI brain networks, and the disentanglement of various social homophily factors in Facebook social networks. The universality of clustering suggests far-reaching impact of our framework throughout all areas of science

Multimodal Data Fusion and Quantitative Analysis for Medical Applications

Medical big data is not only enormous in its size, but also heterogeneous and complex in its data structure, which makes conventional systems or algorithms difficult to process. These heterogeneous medical data include imaging data (e.g., Positron Emission Tomography (PET), Computerized Tomography (CT), Magnetic Resonance Imaging (MRI)), and non-imaging data (e.g., laboratory biomarkers, electronic medical records, and hand-written doctor notes). Multimodal data fusion is an emerging vital field to address this urgent challenge, aiming to process and analyze the complex, diverse and heterogeneous multimodal data. The fusion algorithms bring great potential in medical data analysis, by 1) taking advantage of complementary information from different sources (such as functional-structural complementarity of PET/CT images) and 2) exploiting consensus information that reflects the intrinsic essence (such as the genetic essence underlying medical imaging and clinical symptoms). Thus, multimodal data fusion benefits a wide range of quantitative medical applications, including personalized patient care, more optimal medical operation plan, and preventive public health. Though there has been extensive research on computational approaches for multimodal fusion, there are three major challenges of multimodal data fusion in quantitative medical applications, which are summarized as feature-level fusion, information-level fusion and knowledge-level fusion: • Feature-level fusion. The first challenge is to mine multimodal biomarkers from high-dimensional small-sample multimodal medical datasets, which hinders the effective discovery of informative multimodal biomarkers. Specifically, efficient dimension reduction algorithms are required to alleviate "curse of dimensionality" problem and address the criteria for discovering interpretable, relevant, non-redundant and generalizable multimodal biomarkers. • Information-level fusion. The second challenge is to exploit and interpret inter-modal and intra-modal information for precise clinical decisions. Although radiomics and multi-branch deep learning have been used for implicit information fusion guided with supervision of the labels, there is a lack of methods to explicitly explore inter-modal relationships in medical applications. Unsupervised multimodal learning is able to mine inter-modal relationship as well as reduce the usage of labor-intensive data and explore potential undiscovered biomarkers; however, mining discriminative information without label supervision is an upcoming challenge. Furthermore, the interpretation of complex non-linear cross-modal associations, especially in deep multimodal learning, is another critical challenge in information-level fusion, which hinders the exploration of multimodal interaction in disease mechanism. • Knowledge-level fusion. The third challenge is quantitative knowledge distillation from multi-focus regions on medical imaging. Although characterizing imaging features from single lesions using either feature engineering or deep learning methods have been investigated in recent years, both methods neglect the importance of inter-region spatial relationships. Thus, a topological profiling tool for multi-focus regions is in high demand, which is yet missing in current feature engineering and deep learning methods. Furthermore, incorporating domain knowledge with distilled knowledge from multi-focus regions is another challenge in knowledge-level fusion. To address the three challenges in multimodal data fusion, this thesis provides a multi-level fusion framework for multimodal biomarker mining, multimodal deep learning, and knowledge distillation from multi-focus regions. Specifically, our major contributions in this thesis include: • To address the challenges in feature-level fusion, we propose an Integrative Multimodal Biomarker Mining framework to select interpretable, relevant, non-redundant and generalizable multimodal biomarkers from high-dimensional small-sample imaging and non-imaging data for diagnostic and prognostic applications. The feature selection criteria including representativeness, robustness, discriminability, and non-redundancy are exploited by consensus clustering, Wilcoxon filter, sequential forward selection, and correlation analysis, respectively. SHapley Additive exPlanations (SHAP) method and nomogram are employed to further enhance feature interpretability in machine learning models. • To address the challenges in information-level fusion, we propose an Interpretable Deep Correlational Fusion framework, based on canonical correlation analysis (CCA) for 1) cohesive multimodal fusion of medical imaging and non-imaging data, and 2) interpretation of complex non-linear cross-modal associations. Specifically, two novel loss functions are proposed to optimize the discovery of informative multimodal representations in both supervised and unsupervised deep learning, by jointly learning inter-modal consensus and intra-modal discriminative information. An interpretation module is proposed to decipher the complex non-linear cross-modal association by leveraging interpretation methods in both deep learning and multimodal consensus learning. • To address the challenges in knowledge-level fusion, we proposed a Dynamic Topological Analysis framework, based on persistent homology, for knowledge distillation from inter-connected multi-focus regions in medical imaging and incorporation of domain knowledge. Different from conventional feature engineering and deep learning, our DTA framework is able to explicitly quantify inter-region topological relationships, including global-level geometric structure and community-level clusters. K-simplex Community Graph is proposed to construct the dynamic community graph for representing community-level multi-scale graph structure. The constructed dynamic graph is subsequently tracked with a novel Decomposed Persistence algorithm. Domain knowledge is incorporated into the Adaptive Community Profile, summarizing the tracked multi-scale community topology with additional customizable clinically important factors

Ant Colony Algorithms for the Resolution of Semantic Searches in P2P Networks

Tesis por compendio[EN] The long-lasting trend in the field of computation of stress and resource distribution has found its way into computer networks via the concept of peer-to-peer (P2P) connectivity. P2P is a symmetrical model, where each network node is enabled a comparable range of capacities and resources. It stands in a stark contrast to the classical, strongly asymmetrical client-server approach. P2P, originally considered only a complimentary, server-side structure to the straightforward client-server model, has been shown to have the substantial potential on its own, with multiple, widely known benefits: good fault tolerance and recovery, satisfactory scalability and intrinsic load distribution. However, contrary to client-server, P2P networks require sophisticated solutions on all levels, ranging from network organization, to resource location and managing. In this thesis we address one of the key issues of P2P networks: performing efficient resource searches of semantic nature under realistic, dynamic conditions. There have been numerous solutions to this matter, with evolutionary, stigmergy-based, and simple computational foci, but few attempt to resolve the full range of challenges this problem entails. To name a few: real-life P2P networks are rarely static, nodes disconnect, reconnect and change their content. In addition, a trivial incorporation of semantic searches into well-known algorithms causes significant decrease in search efficiency. In our research we build a solution incrementally, starting with the classic Ant Colony System (ACS) within the Ant Colony Optimization metaheuristic (ACO). ACO is an algorithmic framework used for solving combinatorial optimization problems that fits contractually the problem very well, albeit not providing an immediate solution to any of the aforementioned problems. First, we propose an efficient ACS variant in structured (hypercube structured) P2P networks, by enabling a path-post processing algorithm, which called Tabu Route Optimization (TRO). Next, we proceed to resolve the issue of network dynamism with an ACO-compatible information diffusion approach. Consequently, we attempt to incorporate the semantic component of the searches. This initial approximation to the problem was achieved by allowing ACS to differentiate between search types with the pheromone-per-concept idea. We called the outcome of this merger Routing Concept ACS (RC-ACS). RC-ACS is a robust, static multipheromone implementation of ACS. However, we were able to conclude from it that the pheromone-per-concept approach offers only limited scalability and cannot be considered a global solution. Thus, further progress was made in this respect when we introduced to RC-ACS our novel idea: dynamic pheromone creation, which replaces the static one-to-one assignment. We called the resulting algorithm Angry Ant Framework (AAF). In AAF new pheromone levels are created as needed and during the search, rather than prior to it. The final step was to enable AAF, not only to create pheromone levels, but to reassign them to optimize the pheromone usage. The resulting algorithm is called EntropicAAF and it has been evaluated as one of the top-performing algorithms for P2P semantic searches under all conditions.[ES] La popular tendencia de distribución de carga y recursos en el ámbito de la computación se ha transmitido a las redes computacionales a través del concepto de la conectividad peer-to-peer (P2P). P2P es un modelo simétrico, en el cual a cada nodo de la red se le otorga un rango comparable de capacidades y recursos. Se trata de un fuerte contraste con el clásico y fuertemente asimétrico enfoque cliente-servidor. P2P, originalmente considerado solo como una estructura del lado del servidor complementaria al sencillo modelo cliente-servidor, ha demostrado tener un potencial considerable por sí mismo, con múltiples beneficios ampliamente conocidos: buena tolerancia a fallos y recuperación, escalabilidad satisfactoria y distribución de carga intrínseca. Sin embargo, al contrario que el modelo cliente-servidor, las redes P2P requieren de soluciones sofisticadas a todos los niveles, desde la organización de la red hasta la gestión y localización de recursos. Esta tesis aborda uno de los problemas principales de las redes P2P: la búsqueda eficiente de recursos de naturaleza semántica bajo condiciones dinámicas y realistas. Ha habido numerosas soluciones a este problema basadas en enfoques evolucionarios, estigmérgicos y simples, pero pocas han tratado de resolver el abanico completo de desafíos. En primer lugar, las redes P2P reales son raramente estáticas: los nodos se desconectan, reconectan y cambian de contenido. Además, la incorporación trivial de búsquedas semánticas en algoritmos conocidos causa un decremento significativo de la eficiencia de la búsqueda. En esta investigación se ha construido una solución de manera incremental, comenzando por el clásico Ant Colony System (ACS) basado en la metaheurística de Ant Colony Optimization (ACO). ACO es un framework algorítmico usado para búsquedas en grafos que encaja perfectamente con las condiciones del problema, aunque no provee una solución inmediata a las cuestiones mencionadas anteriormente. En primer lugar, se propone una variante eficiente de ACS para redes P2P estructuradas (con estructura de hipercubo) permitiendo el postprocesamiento de las rutas, al que hemos denominado Tabu Route Optimization (TRO). A continuación, se ha tratado de resolver el problema del dinamismo de la red mediante la difusión de la información a través de una estrategia compatible con ACO. En consecuencia, se ha tratado de incorporar el componente semántico de las búsquedas. Esta aproximación inicial al problema ha sido lograda permitiendo al ACS diferenciar entre tipos de búsquedas através de la idea de pheromone-per-concept. El resultado de esta fusión se ha denominado Routing Concept ACS (RC-ACS). RC-ACS es una implementación multiferomona estática y robusta de ACS. Sin embargo, a partir de esta implementación se ha podido concluir que el enfoque pheromone-per-concept ofrece solo escalabilidad limitada y que no puede ser considerado una solución global. Por lo tanto, para lograr una mejora a este respecto, se ha introducido al RC-ACS una novedosa idea: la creación dinámica de feromonas, que reemplaza la asignación estática uno a uno. En el algoritmo resultante, al que hemos denominado Angry Ant Framework (AAF), los nuevos niveles de feromona se crean conforme se necesitan y durante la búsqueda, en lugar de crearse antes de la misma. La mejora final se ha obtenido al permitir al AAF no solo crear niveles de feromona, sino también reasignarlos para optimizar el uso de la misma. El algoritmo resultante se denomina EntropicAAF y ha sido evaluado como uno de los algoritmos más exitosos para las búsquedas semánticas P2P bajo todas las condiciones.[CA] La popular tendència de distribuir càrrega i recursos en el camp de la computació s'ha estès cap a les xarxes d'ordinadors a través del concepte de connexions d'igual a igual (de l'anglès, peer to peer o P2P). P2P és un model simètric on cada node de la xarxa disposa del mateix nombre de capacitats i recursos. P2P, considerat originàriament només una estructura situada al servidor complementària al model client-servidor simple, ha provat tindre el suficient potencial per ella mateixa, amb múltiples beneficis ben coneguts: una bona tolerància a errades i recuperació, una satisfactòria escalabilitat i una intrínseca distribució de càrrega. No obstant, contràriament al client-servidor, les xarxes P2P requereixen solucions sofisticades a tots els nivells, que varien des de l'organització de la xarxa a la localització de recursos i la seua gestió. En aquesta tesi s'adreça un dels problemes clau de les xarxes P2P: ser capaç de realitzar eficientment cerques de recursos de naturalesa semàntica sota condicions realistes i dinàmiques. Existeixen nombroses solucions a aquest tema basades en la computació simple, evolutiva i també basades en l'estimèrgia (de l'anglès, stigmergy), però pocs esforços s'han realitzat per intentar resoldre l'ampli conjunt de reptes existent. En primer lloc, les xarxes P2P reals són rarament estàtiques: els nodes es connecten, desconnecten i canvien els seus continguts. A més a més, la incorporació trivial de cerques semàntiques als algorismes existents causa una disminució significant de l'eficiència de la cerca. En aquesta recerca s'ha construït una solució incremental, començant pel sistema clàssic de colònia de formigues (de l'anglés, Ant Colony System o ACS) dins de la metaheurística d'optimització de colònies de formigues (de l'anglès, Ant Colony Optimization o ACO). ACO és un entorn algorísmic utilitzat per cercar en grafs i que aborda el problema de forma satisfactòria, tot i que no proveeix d'una solució immediata a cap dels problemes anteriorment mencionats. Primer, s'ha proposat una variant eficient d'ACS en xarxes P2P estructurades (en forma d'hipercub) a través d'un algorisme de processament post-camí el qual s'ha anomenat en anglès Tabu Route Optimization (TRO). A continuació, s'ha procedit a resoldre el problema del dinamisme de les xarxes amb un enfocament de difusió d'informació compatible amb ACO. Com a conseqüència, s'ha intentat incorporar la component semàntica de les cerques. Aquest enfocament inicial al problema s'ha realitzat permetent a ACS diferenciar entre tipus de cerques amb la idea de ''feromona per concepte'', i s'ha anomenat a aquest producte Routing Concept ACS o RC-ACS. RC-ACS és una implementació multi-feromona robusta i estàtica d'ACS. No obstant, s'ha pogut concloure que l'enfocament de feromona per concepte ofereix només una escalabilitat limitada i no pot ser considerada una solució global. En aquest respecte s'ha realitzat progrés posteriorment introduint una nova idea a RC-ACS: la creació dinàmica de feromones, la qual reemplaça a l'assignació un a un de les mateixes. A l'algorisme resultant se l'ha anomenat en anglès Angry Ant Framework (AAF). En AAF es creen nous nivells de feromones a mesura que es necessiten durant la cerca, i no abans d'aquesta. El progrés final s'ha aconseguit quan s'ha permès a AAF, no sols crear nivells de feromones, sinó reassignar-los per optimitzar la utilització de feromones. L'algorisme resultant s'ha anomenat EntropicAAF i ha sigut avaluat com un dels algorismes per a cerques semàntiques P2P amb millors prestacions.Krynicki, KK. (2016). Ant Colony Algorithms for the Resolution of Semantic Searches in P2P Networks [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/61293TESISPremios Extraordinarios de tesis doctoralesCompendi