Request for proposals final with addendum 1

The purpose of this Request for Proposals (RFP) is to select a Proposer to perform the Project services described in this RFP. SCDOT desires that this Project be constructed in a very efficient and timely manner. This proposal is for a design-build project for a Closed and Load Restricted Bridge Package for Abbeville, Greenwood, Laurens, McCormick, Newberry, and Saluda Counties

Annual reports of the selectmen, treasurer, school board and all other officers and committees for the town of Fremont, New Hampshire for the fiscal year ending December 31, 2007.

This is an annual report containing vital statistics for a town/city in the state of New Hampshire

Carolina Crossroads phase 1 - Colonial Life Blvd. Richland and Lexington Counties, South Carolina a design-build project

SCDOT proposes to construct a new exit ramp to US 378 from I-26 eastbound and associated interstate widening in Lexington County and a full access interchange at Colonial Life Boulevard at I-126 in Richland County. This will include construction of new bridges and related roadway approaches. The purpose of the project is to provide traffic access to and from I-26 and I-126 to Colonial Life Blvd., allowing for closure of the existing on and off ramps that access I-26 from Bush River Road. The purpose of this Request for Proposals (RFP) is to select a Proposer to perform the Project services described in this RFP

Request for proposals final with addendum 6 : Carolina Crossroads phase 2 - Broad River Rd. at I-20 Interchange design-build project Project ID P039719 Richland County December 3, 2020

The purpose of this Request for Proposals (RFP) is to select a Proposer to perform the Project services and to design and construct the Project, as further described in this RFP

Integrating O/S models during conceptual design, part 2

This report documents the procedures for utilizing and maintaining the Reliability & Maintainability Model (RAM) developed by the University of Dayton for the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) under NASA research grant NAG-1-1327. The purpose of the grant is to provide support to NASA in establishing operational and support parameters and costs of proposed space systems. As part of this research objective, the model described here was developed. Additional documentation concerning the development of this model may be found in Part 1 of this report. This is the 2nd part of a 3 part technical report

Genetic epidemiology of breast cancer in CYPRUS: A case -control study of DNA repair genes

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The occurrence of early-onset breast cancer (EOBC) has been associated with germline mutations in the BRCA1 and BRCA2 genes. The first aim of this thesis was to evaluate the frequency and distribution of mutations in these genes, in a group of Cypriot women diagnosed with EOBC. Pathogenic mutations were identified in 6 of the 26 unrelated patients. This study supports a strong correlation between the early onset breast cancer phenotype and the presence of pathogenic BRCA1/2 mutations. It is of interest that pathogenic mutations were detected in patients without a family history of the disease. Based on these results, we recommend that BRCA1/2 screening should be offered to patients with a diagnosis of EOBC irrespective of their family history. The known breast cancer susceptibility genes explain only about 5% of breast cancer cases. Thus, it is likely that other breast cancer susceptibility genes exist. The second aim of the present thesis was to assess whether alterations in DNA repair genes modify breast cancer risk in the Cypriot population. Towards this objective, blood samples were collected and genomic DNA isolated from 1109 Cypriot female breast cancer patients diagnosed between 40-70 years old, and from 1177 age-matched healthy female controls. A total of 79 single nucleotide polymorphisms (SNPs) were genotyped in all samples. Significant associations with breast cancer risk were observed for eight of the SNPs studied. Five SNPs in the BRCA2, MRE11A, MUS81, PBOV1 and XRCC1 genes, were associated with an increased risk for breast cancer, while two SNPs in the NBS1 gene and one SNP in the MRE11A gene appeared to be associated with reduced risk for the disease. The data from this study support the hypothesis that genetic variants in DNA repair genes influence breast cancer risk and provides further evidence for the existence of a polygenic model for breast cancer

Reliability and Maintainability model (RAM) user and maintenance manual

This report documents the procedures for utilizing and maintaining the Reliability and Maintainability Model (RAM) developed by the University of Dayton for the NASA Langley Research Center (LaRC). The RAM model predicts reliability and maintainability (R&M) parameters for conceptual space vehicles using parametric relationships between vehicle design and performance characteristics and subsystem mean time between maintenance actions (MTBM) and manhours per maintenance action (MH/MA). These parametric relationships were developed using aircraft R&M data from over thirty different military aircraft of all types. This report describes the general methodology used within the model, the execution and computational sequence, the input screens and data, the output displays and reports, and study analyses and procedures. A source listing is provided