Probabilistic Kernel Support Vector Machines

We propose a probabilistic enhancement of standard kernel Support Vector Machines for binary classification, in order to address the case when, along with given data sets, a description of uncertainty (e.g., error bounds) may be available on each datum. In the present paper, we specifically consider Gaussian distributions to model uncertainty. Thereby, our data consist of pairs $(x_i,\Sigma_i)$, $i\in\{1,\ldots,N\}$, along with an indicator $y_i\in\{-1,1\}$ to declare membership in one of two categories for each pair. These pairs may be viewed to represent the mean and covariance, respectively, of random vectors $\xi_i$ taking values in a suitable linear space (typically $\mathbb R^n$). Thus, our setting may also be viewed as a modification of Support Vector Machines to classify distributions, albeit, at present, only Gaussian ones. We outline the formalism that allows computing suitable classifiers via a natural modification of the standard "kernel trick." The main contribution of this work is to point out a suitable kernel function for applying Support Vector techniques to the setting of uncertain data for which a detailed uncertainty description is also available (herein, "Gaussian points").Comment: 6 pages, 6 figure

Statistical Learning Theory for Location Fingerprinting in Wireless LANs

In this paper, techniques and algorithms developed in the framework of statistical learning theory are analyzed and applied to the problem of determining the location of a wireless device by measuring the signal strengths from a set of access points (location fingerprinting). Statistical Learning Theory provides a rich theoretical basis for the development of models starting from a set of examples. Signal strength measurement is part of the normal operating mode of wireless equipment, in particular Wi-Fi, so that no custom hardware is required. The proposed techniques, based on the Support Vector Machine paradigm, have been implemented and compared, on the same data set, with other approaches considered in the literature. Tests performed in a real-world environment show that results are comparable, with the advantage of a low algorithmic complexity in the normal operating phase. Moreover, the algorithm is particularly suitable for classification, where it outperforms the other techniques

Nonlinear Channel Estimation for OFDM System by Complex LS-SVM under High Mobility Conditions

A nonlinear channel estimator using complex Least Square Support Vector Machines (LS-SVM) is proposed for pilot-aided OFDM system and applied to Long Term Evolution (LTE) downlink under high mobility conditions. The estimation algorithm makes use of the reference signals to estimate the total frequency response of the highly selective multipath channel in the presence of non-Gaussian impulse noise interfering with pilot signals. Thus, the algorithm maps trained data into a high dimensional feature space and uses the structural risk minimization (SRM) principle to carry out the regression estimation for the frequency response function of the highly selective channel. The simulations show the effectiveness of the proposed method which has good performance and high precision to track the variations of the fading channels compared to the conventional LS method and it is robust at high speed mobility.Comment: 11 page

Support vector machine for functional data classification

In many applications, input data are sampled functions taking their values in infinite dimensional spaces rather than standard vectors. This fact has complex consequences on data analysis algorithms that motivate modifications of them. In fact most of the traditional data analysis tools for regression, classification and clustering have been adapted to functional inputs under the general name of functional Data Analysis (FDA). In this paper, we investigate the use of Support Vector Machines (SVMs) for functional data analysis and we focus on the problem of curves discrimination. SVMs are large margin classifier tools based on implicit non linear mappings of the considered data into high dimensional spaces thanks to kernels. We show how to define simple kernels that take into account the unctional nature of the data and lead to consistent classification. Experiments conducted on real world data emphasize the benefit of taking into account some functional aspects of the problems.Comment: 13 page

Machine learning-guided directed evolution for protein engineering

Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying physics or biological pathways. To demonstrate ML-guided directed evolution, we introduce the steps required to build ML sequence-function models and use them to guide engineering, making recommendations at each stage. This review covers basic concepts relevant to using ML for protein engineering as well as the current literature and applications of this new engineering paradigm. ML methods accelerate directed evolution by learning from information contained in all measured variants and using that information to select sequences that are likely to be improved. We then provide two case studies that demonstrate the ML-guided directed evolution process. We also look to future opportunities where ML will enable discovery of new protein functions and uncover the relationship between protein sequence and function.Comment: Made significant revisions to focus on aspects most relevant to applying machine learning to speed up directed evolutio

Theoretical Interpretations and Applications of Radial Basis Function Networks

Medical applications usually used Radial Basis Function Networks just as Artificial Neural Networks. However, RBFNs are Knowledge-Based Networks that can be interpreted in several way: Artificial Neural Networks, Regularization Networks, Support Vector Machines, Wavelet Networks, Fuzzy Controllers, Kernel Estimators, Instanced-Based Learners. A survey of their interpretations and of their corresponding learning algorithms is provided as well as a brief survey on dynamic learning algorithms. RBFNs' interpretations can suggest applications that are particularly interesting in medical domains