2,997 research outputs found
Mobile heritage practices. Implications for scholarly research, user experience design, and evaluation methods using mobile apps.
Mobile heritage apps have become one of the most popular means for audience
engagement and curation of museum collections and heritage contexts. This
raises practical and ethical questions for both researchers and practitioners, such
as: what kind of audience engagement can be built using mobile apps? what are
the current approaches? how can audience engagement with these experience
be evaluated? how can those experiences be made more resilient, and in turn
sustainable? In this thesis I explore experience design scholarships together with
personal professional insights to analyse digital heritage practices with a view to
accelerating thinking about and critique of mobile apps in particular. As a result,
the chapters that follow here look at the evolution of digital heritage practices,
examining the cultural, societal, and technological contexts in which mobile
heritage apps are developed by the creative media industry, the academic
institutions, and how these forces are shaping the user experience design
methods. Drawing from studies in digital (critical) heritage, Human-Computer
Interaction (HCI), and design thinking, this thesis provides a critical analysis of
the development and use of mobile practices for the heritage. Furthermore,
through an empirical and embedded approach to research, the thesis also
presents auto-ethnographic case studies in order to show evidence that mobile
experiences conceptualised by more organic design approaches, can result in
more resilient and sustainable heritage practices. By doing so, this thesis
encourages a renewed understanding of the pivotal role of these practices in the
broader sociocultural, political and environmental changes.AHRC REAC
Unravelling the complex reproductive tactics of male humpback whales : an integrative analysis of paternity, age, testosterone, and genetic diversity
How the underlying forces of sexual selection impact reproductive tactics including elaborate acoustic displays in cetaceans remains poorly understood. Here, I combined 26 years (1995-2020) of photo-identification, behavioural, (epi)genetic, and endocrine data from an endangered population of humpback whales (New Caledonia), to explore male reproductive success, age, physiology, and population dynamics over almost a third of the lifespan of a humpback whale. First, I conducted a paternity analysis on 177 known mother-offspring pairs and confirmed previous findings of low variation in reproductive success in male humpback whales. Second, epigenetic age estimates of 485 males revealed a left-skewed population age structure in the first half of the study period that became more balanced in the second half. Further, older males (> 23 years) more often engaged in certain reproductive tactics (singing and escorting) and were more successful in siring offspring once the population age structure stabilised, suggesting reproductive tactics and reproductive success in male humpback whales may be age-dependent. Third, using enzyme immunoassays on 457 blubber samples, I observed a seasonal decline in male testosterone in the population over the breeding season. Testosterone levels appeared highest during puberty, then decreased and levelled off at the onset of maturity, yet were highly variable at any point during the breeding season and across males of all ages. Lastly, I investigated the influence of genetic diversity at the major histocompatibility complex (MHC) class I and class IIa (DQB and DRB-a) on patterns of male reproductive success in humpback whales. Mating pairs shared fewer alleles than expected under random mating at MHC class I and IIa, thus, providing evidence of an MHC-mediated female mate choice in humpback whales. This thesis provides novel, critical insights into the evolutionary consequences of commercial whaling on the demography, patterns of reproduction and sexual selection of exploited populations of baleen whales."This work was supported by a University of St Andrews School of Biology Ph.D. Scholarship and the Louis M. Herman Research Scholarship 2022 to Franca Eichenberger. Sample collection and analyses from 2018-2020 were supported by grants to Ellen C. Garland (Royal Society University Research Fellowship (UF160081 & URF\R\221020), Royal Society Research Fellows Enhancement Award (RGF\EA\180213), Royal Society Research Grants for Research Fellows 2018 (RGF\R1\181014), National Geographic Grant (#NGS-50654R-18), Carnegie Trust Research Incentive Grant (RIG007772), British Ecological Society Small Research Grant (SR18/1288) and School of Biology Research Committee funding)."--Fundin
Impaired risk avoidance in bipolar disorder and substance use disorders
Comorbid substance use disorders (SUDs) are highly prevalent in bipolar disorder (BD), with up to 60% of individuals with BD developing an SUD at some point in their lifetime. In addition, research suggests that individuals with this comorbid presentation (BD+SUD) typically have worse outcomes -- including increased mortality, morbidity, and functional impairment -- than individuals with BD alone. Given the increased illness burden associated with BD+SUD, I conducted a systematic review evaluating existing psychosocial treatments for individuals with these comorbidities. Results from this review indicated that no existing psychosocial treatments for these comorbid conditions effectively target both the substance use and mood domain of symptoms. An alternative path to treatment development is to identify mechanisms that underlie BD+SUD that can subsequently be targeted in treatment. Accordingly, I evaluated impairments in risk avoidance (a tendency to engage in a persistent pattern of problematic behaviors despite negative outcomes resulting from such behaviors) as a potential mechanism underlying negative illness outcomes in BD+SUD. Participants with BD (n = 45) or BD+SUD (n = 31) in a relatively euthymic mood state completed clinical risk behavior assessments, laboratory-based risk avoidance assessments, and neurocognitive assessments in a single study session. I hypothesized that the BD+SUD group would exhibit increased clinical risk behaviors, increased impairments on laboratory-based measures of risk avoidance, and increased deficits on neurocognitive assessments relative to the bipolar disorder alone group. Contrary to my hypotheses, results indicated a lack of notable between-group differences in clinical risk behaviors, laboratory-based risk avoidance assessments, and neurocognitive assessments, with the exception of self-reported executive dysfunction which was elevated among individuals with BD+SUD. Collapsing across group, I found that increased discounting of delayed rewards, older age, and an earlier age of (hypo)mania onset predicted increased clinical risk behaviors. These findings underscore the potential importance of delay discounting as a mechanistic target for reducing clinical risk behaviors among individuals with BD both with and without comorbid SUDs. I also discuss the neurocognitive correlates of delay discounting and interventions for addressing delay discounting as potential new directions for treating the disability associated with BD
Elements, Government, and Licensing: Developments in phonology
Elements, Government, and Licensing brings together new theoretical and empirical developments in phonology. It covers three principal domains of phonological representation: melody and segmental structure; tone, prosody and prosodic structure; and phonological relations, empty categories, and vowel-zero alternations. Theoretical topics covered include the formalisation of Element Theory, the hotly debated topic of structural recursion in phonology, and the empirical status of government.
In addition, a wealth of new analyses and empirical evidence sheds new light on empty categories in phonology, the analysis of certain consonantal sequences, phonological and non-phonological alternation, the elemental composition of segments, and many more. Taking up long-standing empirical and theoretical issues informed by the Government Phonology and Element Theory, this book provides theoretical advances while also bringing to light new empirical evidence and analysis challenging previous generalisations.
The insights offered here will be equally exciting for phonologists working on related issues inside and outside the Principles & Parameters programme, such as researchers working in Optimality Theory or classical rule-based phonology
An empirical evaluation of m-health service users’ behaviours: A case of Bangladesh
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of Philosophy.Mobile health (m-health) services are revolutionising healthcare in the developing world by improving accessibility, affordability, and availability. Although these services are revolutionising healthcare in various ways, there are growing concerns regarding users' service quality perceptions and overall influence on satisfaction and usage behaviours. In developing countries, access to healthcare and low healthcare costs are insufficient if users lack confidence in healthcare service quality.
Bangladesh's Directorate General of Health Services (DGHS) provides the only government-sponsored m-health service available to the entire population. DGHS's m-health service, available since 2009, is yet to be evaluated in terms of users' perceptions of the quality of service and its impact on satisfaction and usage. Hence, this study developed a conceptual model for evaluating the associations between overall DGHS m-health service quality, satisfaction, and usage behaviours. This study operationalised overall m-health service quality as a higher-order construct with three dimensions- platform quality, information quality, and outcome quality, and nine corresponding subdimensions-privacy, systems availability, systems reliability, systems efficiency, responsiveness, empathy, assurance, emotional benefit, and functional benefit.
Moreover, researchers in various service domains, including- healthcare, marketing, environmental protection, and information systems, evaluated and confirmed the influence of social and personal norms on satisfaction and behavioural outcomes like- intention to use. Despite this, no research has been conducted to determine whether these normative components affect m-health users' service satisfaction and usage behaviours. As a result, this study included social and personal norms along with overall service quality into the conceptual model to assess the influence of these variables on users' satisfaction and m-health service usage behaviours. Data was collected from two districts in Bangladesh- Dhaka and Rajshahi, utilising the online survey approach. A total of 417 usable questionnaires were analysed using partial least squares structural equation modelling to investigate the relationships between the constructs in Warp PLS.
The study confirms that all three dimensions of service quality and their corresponding subdimensions influence users' overall perceptions of DGHS m-health service quality. Moreover, overall DGHS m-health service quality has a significant direct association with satisfaction and an indirect association with usage behaviours through satisfaction. While social norms do not influence satisfaction and usage behaviours within the DGHS m-health context, personal norms directly influence users' satisfaction and indirectly influence usage behaviours through satisfaction. Theoretically, the study contributes by framing the influence of users' overall m-health service quality perceptions, social and personal norms on their actual usage behaviours rather than the intention to use. It also extends the existing knowledge by assessing and comparing m-health users' continuous and discontinuous behaviours. Methodologically this study confirms the usefulness of partial least squares structural equational modelling to analyse a complex model including a higher order construct (i.e., overall perceived service quality). Practically, the study demonstrates the importance of users' satisfaction in addition to service quality, as service quality only affects usage behaviours through satisfaction in the current study context. Additionally, knowing that personal norms significantly influence service satisfaction motivates providers of m-health services to strive to enhance users' personal norms toward m-health service to enhance service satisfaction and usage. Overall, the study will help enhance patient outcomes and m-health service usage
Molecular signals of arms race evolution between RNA viruses and their hosts
Viruses are intracellular parasites that hijack their hosts’ cellular machinery to replicate themselves. This creates an evolutionary “arms race” between hosts and viruses, where the former develop mechanisms to restrict viral infection and the latter evolve ways to circumvent these molecular barriers. In this thesis, I explore examples of this virus-host molecular interplay, focusing on events in the evolutionary histories of both viruses and hosts. The thesis begins by examining how recombination, the exchange of genetic material between related viruses, expands the genomic diversity of the Sarbecovirus subgenus, which includes SARS-CoV responsible for the 2002 SARS epidemic and SARS-CoV-2 responsible for the COVID-19 pandemic. On the host side, I examine the evolutionary interaction between RNA viruses and two interferon-stimulated genes expressed in hosts. First, I show how the 2′-5′-oligoadenylate synthetase 1 (OAS1) gene of horseshoe bats (Rhinolophoidea), the reservoir host of sarbecoviruses, lost its anti-coronaviral activity at the base of this bat superfamily. By reconstructing the Rhinolophoidea common ancestor OAS1 protein, I first validate the loss of antiviral function and highlight the implications of this event in the virus-host association between sarbecoviruses and horseshoe bat hosts. Second, I focus on the evolution of the human butyrophilin subfamily 3 member A3 (BTN3A3) gene which restricts infection by avian influenza A viruses (IAV). The evolutionary analysis reveals that BTN3A3’s anti-IAV function was gained within the primates and that specific amino acid substitutions need to be acquired in IAVs’ NP protein to evade the human BTN3A3 activity. Gain of BTN3A3-evasion-conferring substitutions correlate with all major human IAV pandemics and epidemics, making these NP residues key markers for IAV transmissibility potential to humans. In the final part of the thesis, I present a novel approach for evaluating dinucleotide compositional biases in virus genomes. An application of my metric on the Flaviviridae virus family uncovers how ancestral host shifts of these viruses correlate with adaptive shifts in their genomes’ dinucleotide representation. Collectively, the contents of this thesis extend our understanding of how viruses interact with their hosts along their intertangled evolution and provide insights into virus host switching and pandemic preparedness
Utilizing Reinforcement Learning and Computer Vision in a Pick-And-Place Operation for Sorting Objects in Motion
This master's thesis studies the implementation of advanced machine learning (ML) techniques in industrial automation systems, focusing on applying machine learning to enable and evolve autonomous sorting capabilities in robotic manipulators. In particular, Inverse Kinematics (IK) and Reinforcement Learning (RL) are investigated as methods for controlling a UR10e robotic arm for pick-and-place of moving objects on a conveyor belt within a small-scale sorting facility. A camera-based computer vision system applying YOLOv8 is used for real-time object detection and instance segmentation. Perception data is utilized to ascertain optimal grip points, specifically through an implemented algorithm that outputs optimal grip position, angle, and width. As the implemented system includes testing and evaluation on a physical system, the intricacies of hardware control, specifically the reverse engineering of an OnRobot RG6 gripper is elaborated as part of this study.
The system is implemented on the Robotic Operating System (ROS), and its design is in particular driven by high modularity and scalability in mind. The camera-based vision system serves as the primary input, while the robot control is the output. The implemented system design allows for the evaluation of motion control employing both IK and RL. Computation of IK is conducted via MoveIt2, while the RL model is trained and computed in NVIDIA Isaac Sim.
The high-level control of the robotic manipulator was accomplished with use of Proximal Policy Optimization (PPO). The main result of the research is a novel reward function for the pick-and-place operation that takes into account distance and orientation from the target object. In addition, the provided system administers task control by independently initializing pick-and-place operation phases for each environment. The findings demonstrate that PPO was able to significantly enhance the velocity, accuracy, and adaptability of industrial automation. Our research shows that accurate control of the robot arm can be reached by training the PPO Model purely by applying a digital twin simulation
Science and Innovations for Food Systems Transformation
This Open Access book compiles the findings of the Scientific Group of the United Nations Food Systems Summit 2021 and its research partners. The Scientific Group was an independent group of 28 food systems scientists from all over the world with a mandate from the Deputy Secretary-General of the United Nations. The chapters provide science- and research-based, state-of-the-art, solution-oriented knowledge and evidence to inform the transformation of contemporary food systems in order to achieve more sustainable, equitable and resilient systems
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