What does intrinsic mean in statistical estimation?

In this paper we review different meanings of the word intrinsic in statistical estimation, focusing our attention on the use of this word in the analysis of the properties of an estimator.We review the intrinsic versions of the bias and the mean square error and results analogous to the Cram'er-Rao inequality and Rao-Blackwell theorem. Different results related to the Bernoulli and normal distributions are also considered

Long runs under a conditional limit distribution

This paper presents a sharp approximation of the density of long runs of a random walk conditioned on its end value or by an average of a function of its summands as their number tends to infinity. In the large deviation range of the conditioning event it extends the Gibbs conditional principle in the sense that it provides a description of the distribution of the random walk on long subsequences. An approximation of the density of the runs is also obtained when the conditioning event states that the end value of the random walk belongs to a thin or a thick set with a nonempty interior. The approximations hold either in probability under the conditional distribution of the random walk, or in total variation norm between measures. An application of the approximation scheme to the evaluation of rare event probabilities through importance sampling is provided. When the conditioning event is in the range of the central limit theorem, it provides a tool for statistical inference in the sense that it produces an effective way to implement the Rao-Blackwell theorem for the improvement of estimators; it also leads to conditional inference procedures in models with nuisance parameters. An algorithm for the simulation of such long runs is presented, together with an algorithm determining the maximal length for which the approximation is valid up to a prescribed accuracy.Comment: Published in at http://dx.doi.org/10.1214/13-AAP975 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org). arXiv admin note: text overlap with arXiv:1010.361

Conditional limit laws for goodness-of-fit tests

We study the conditional distribution of goodness of fit statistics of the Cram\'{e}r--von Mises type given the complete sufficient statistics in testing for exponential family models. We show that this distribution is close, in large samples, to that given by parametric bootstrapping, namely, the unconditional distribution of the statistic under the value of the parameter given by the maximum likelihood estimate. As part of the proof, we give uniform Edgeworth expansions of Rao--Blackwell estimates in these models.Comment: Published in at http://dx.doi.org/10.3150/11-BEJ366 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm

Conditional Estimation in Two-stage Adaptive Designs

We consider conditional estimation in two-stage sample size adjustable designs and the following bias. More specifically, we consider a design which permits raising the sample size when interim results look rather promising, and, which keeps the originally planned sample size when results look very promising. The estimation procedures reported comprise the unconditional maximum likelihood, the conditionally unbiased Rao-Blackwell estimator, the conditional median unbiased estimator, and the conditional maximum likelihood with and without bias correction. We compare these estimators based on analytical results and by a simulation study. We show in a real clinical trial setting how they can be applied