6,904 research outputs found
Grid multi-category response logistic models.
BackgroundMulti-category response models are very important complements to binary logistic models in medical decision-making. Decomposing model construction by aggregating computation developed at different sites is necessary when data cannot be moved outside institutions due to privacy or other concerns. Such decomposition makes it possible to conduct grid computing to protect the privacy of individual observations.MethodsThis paper proposes two grid multi-category response models for ordinal and multinomial logistic regressions. Grid computation to test model assumptions is also developed for these two types of models. In addition, we present grid methods for goodness-of-fit assessment and for classification performance evaluation.ResultsSimulation results show that the grid models produce the same results as those obtained from corresponding centralized models, demonstrating that it is possible to build models using multi-center data without losing accuracy or transmitting observation-level data. Two real data sets are used to evaluate the performance of our proposed grid models.ConclusionsThe grid fitting method offers a practical solution for resolving privacy and other issues caused by pooling all data in a central site. The proposed method is applicable for various likelihood estimation problems, including other generalized linear models
Adaptive Segmentation of Knee Radiographs for Selecting the Optimal ROI in Texture Analysis
The purposes of this study were to investigate: 1) the effect of placement of
region-of-interest (ROI) for texture analysis of subchondral bone in knee
radiographs, and 2) the ability of several texture descriptors to distinguish
between the knees with and without radiographic osteoarthritis (OA). Bilateral
posterior-anterior knee radiographs were analyzed from the baseline of OAI and
MOST datasets. A fully automatic method to locate the most informative region
from subchondral bone using adaptive segmentation was developed. We used an
oversegmentation strategy for partitioning knee images into the compact regions
that follow natural texture boundaries. LBP, Fractal Dimension (FD), Haralick
features, Shannon entropy, and HOG methods were computed within the standard
ROI and within the proposed adaptive ROIs. Subsequently, we built logistic
regression models to identify and compare the performances of each texture
descriptor and each ROI placement method using 5-fold cross validation setting.
Importantly, we also investigated the generalizability of our approach by
training the models on OAI and testing them on MOST dataset.We used area under
the receiver operating characteristic (ROC) curve (AUC) and average precision
(AP) obtained from the precision-recall (PR) curve to compare the results. We
found that the adaptive ROI improves the classification performance (OA vs.
non-OA) over the commonly used standard ROI (up to 9% percent increase in AUC).
We also observed that, from all texture parameters, LBP yielded the best
performance in all settings with the best AUC of 0.840 [0.825, 0.852] and
associated AP of 0.804 [0.786, 0.820]. Compared to the current state-of-the-art
approaches, our results suggest that the proposed adaptive ROI approach in
texture analysis of subchondral bone can increase the diagnostic performance
for detecting the presence of radiographic OA
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Early symptoms and sensations as predictors of lung cancer: a machine learning multivariate model.
The aim of this study was to identify a combination of early predictive symptoms/sensations attributable to primary lung cancer (LC). An interactive e-questionnaire comprised of pre-diagnostic descriptors of first symptoms/sensations was administered to patients referred for suspected LC. Respondents were included in the present analysis only if they later received a primary LC diagnosis or had no cancer; and inclusion of each descriptor required ≥4 observations. Fully-completed data from 506/670 individuals later diagnosed with primary LC (n = 311) or no cancer (n = 195) were modelled with orthogonal projections to latent structures (OPLS). After analysing 145/285 descriptors, meeting inclusion criteria, through randomised seven-fold cross-validation (six-fold training set: n = 433; test set: n = 73), 63 provided best LC prediction. The most-significant LC-positive descriptors included a cough that varied over the day, back pain/aches/discomfort, early satiety, appetite loss, and having less strength. Upon combining the descriptors with the background variables current smoking, a cold/flu or pneumonia within the past two years, female sex, older age, a history of COPD (positive LC-association); antibiotics within the past two years, and a history of pneumonia (negative LC-association); the resulting 70-variable model had accurate cross-validated test set performance: area under the ROC curve = 0.767 (descriptors only: 0.736/background predictors only: 0.652), sensitivity = 84.8% (73.9/76.1%, respectively), specificity = 55.6% (66.7/51.9%, respectively). In conclusion, accurate prediction of LC was found through 63 early symptoms/sensations and seven background factors. Further research and precision in this model may lead to a tool for referral and LC diagnostic decision-making
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