Oxygen targeting in preterm infants: a physiological interpretation.

Randomized controlled trials evaluating low-target oxygen saturation (SpO2:85% to 89%) vs high-target SpO2 (91% to 95%) have shown variable results regarding mortality and morbidity in extremely preterm infants. Because of the variation inherent to the accuracy of pulse oximeters, the unspecified location of probe placement, the intrinsic relationship between SpO2 and arterial oxygen saturation (SaO2) and between SaO2 and partial pressure of oxygen (PaO2) (differences in oxygen dissociation curves for fetal and adult hemoglobin), the two comparison groups could have been more similar than dissimilar. The SpO2 values were in the target range for a shorter period of time than intended due to practical and methodological constraints. So the studies did not truly compare 'target SpO2 ranges'. In spite of this overlap, some of the studies did find significant differences in mortality prior to discharge, necrotizing enterocolitis and severe retinopathy of prematurity. These differences could potentially be secondary to time spent beyond the target range (SpO2 <85 or >95%) and could be avoided with an intermediate but wider target SpO2 range (87% to 93%). In conclusion, significant uncertainty persists about the desired target range of SpO2 in extremely preterm infants. Further studies should focus on studying newer methods of assessing oxygenation and strategies to limit hypoxemia (<85% SpO2) and hyperoxemia (>95% SpO2)

Tailoring laser-generated plasmas for efficient nuclear excitation by electron capture

The optimal parameters for nuclear excitation by electron capture in plasma environments generated by the interaction of ultra-strong optical lasers with solid matter are investigated theoretically. As a case study we consider a 4.85 keV nuclear transition starting from the long-lived $^{93\mathrm{m}}$Mo isomer that can lead to the release of the stored 2.4 MeV excitation energy. We find that due to the complex plasma dynamics, the nuclear excitation rate and the actual number of excited nuclei do not reach their maximum at the same laser parameters. The nuclear excitation achievable with a high-power optical laser is up to twelve and up to six orders of magnitude larger than the values predicted for direct resonant and secondary plasma-mediated excitation at the x-ray free electron laser, respectively. Our results show that the experimental observation of the nuclear excitation of $^{93\mathrm{m}}$Mo and the subsequent release of stored energy should be possible at laser facilities available today.Comment: 6 pages, 3 figures, 1 table; minor modifications made; accepted for publication in Physical Review Letter

Evaluation of critical congenital heart defects screening using pulse oximetry in the neonatal intensive care unit.

ObjectiveTo evaluate the implementation of early screening for critical congenital heart defects (CCHDs) in the neonatal intensive care unit (NICU) and potential exclusion of sub-populations from universal screening.Study designProspective evaluation of CCHD screening at multiple time intervals was conducted in 21 NICUs across five states (n=4556 infants).ResultsOf the 4120 infants with complete screens, 92% did not have prenatal CHD diagnosis or echocardiography before screening, 72% were not receiving oxygen at 24 to 48 h and 56% were born ⩾2500 g. Thirty-seven infants failed screening (0.9%); none with an unsuspected CCHD. False positive rates were low for infants not receiving oxygen (0.5%) and those screened after weaning (0.6%), yet higher among infants born at <28 weeks (3.8%). Unnecessary echocardiograms were minimal (0.2%).ConclusionGiven the majority of NICU infants were ⩾2500 g, not on oxygen and not preidentified for CCHD, systematic screening at 24 to 48 h may be of benefit for early detection of CCHD with minimal burden

Modeling Quantum Optical Components, Pulses and Fiber Channels Using OMNeT++

Quantum Key Distribution (QKD) is an innovative technology which exploits the laws of quantum mechanics to generate and distribute unconditionally secure cryptographic keys. While QKD offers the promise of unconditionally secure key distribution, real world systems are built from non-ideal components which necessitates the need to model and understand the impact these non-idealities have on system performance and security. OMNeT++ has been used as a basis to develop a simulation framework to support this endeavor. This framework, referred to as "qkdX" extends OMNeT++'s module and message abstractions to efficiently model optical components, optical pulses, operating protocols and processes. This paper presents the design of this framework including how OMNeT++'s abstractions have been utilized to model quantum optical components, optical pulses, fiber and free space channels. Furthermore, from our toolbox of created components, we present various notional and real QKD systems, which have been studied and analyzed.Comment: Published in: A. F\"orster, C. Minkenberg, G. R. Herrera, M. Kirsche (Eds.), Proc. of the 2nd OMNeT++ Community Summit, IBM Research - Zurich, Switzerland, September 3-4, 201

Atomic secrets and governmental lies : nuclear science, politics and security in the Pontecorvo case

This paper focuses on the defection of nuclear physicist Bruno Pontecorvo from Britain to the USSR in 1950 in an attempt to understand how government and intelligence services assess threats deriving from the unwanted spread of secret scientific information. It questions whether contingent agendas play a role in these assessments, as new evidence suggests that this is exactly what happened in the Pontecorvo case. British diplomatic personnel involved in negotiations with their US counterparts considered playing down the case. Meanwhile, the press decided to play it up, claiming that Pontecorvo was an atom spy. Finally, the British secret services had evidence showing that this was a fabrication, but they did not disclose it. If all these manipulations served various purposes, then they certainly were not aimed at assessing if there was a threat and what this threat really was