Molluscum contagiosum infection with features of primary cutaneous anaplastic large cell lymphoma

CD30+ T cell pseudolymphomas (CD30+ PSL) are a group of benign inflammatory cutaneous disorders that can develop in settings of viral infections or drug reactions. Owing to their histological similarities to malignant lymphomas, these benign infiltrates are occasionally misdiagnosed as malignant, causing significant concerns for patients and physicians. Herein, we report a patient with CD30+ PSL associated with molluscum contagiosum whose initial biopsy revealed atypical large CD30-expressing cells, leading to a misdiagnosis of primary cutaneous anaplastic large cell lymphoma and referral to our cutaneous lymphoma clinic. We report this case to demonstrate that reactive CD30+ infiltrate associated with molluscum contagiosum can be mistaken for T-cell lymphomas and patients should be reassured in these cases

Complications in Leech Therapy: How to Prevent and Manage Them

Medical Leech Therapy (MLT) is a traditional medical treatment method that utilizes leeches to bloodsuck and release saliva for the treatment of diseases. However, the use of living leeches for blood drinking may lead to a series of adverse reactions and complications, which may have a negative impact on the patient's health. This article provides a summary of the complications associated with leech therapy in recent years, along with corresponding mitigation measures. The information presented aims to offer medical practitioners using leech therapy a point of reference. Searching Pubmed database in the past 15 years (2008 to 2023), English articles were retrieved with "Leech", "Leeche", "Leech Therapy", "Leeching", "Hirudinea", "Hirudineas", "Hirudotherapy" as keywords. We have identified a total of 19 articles that explicitly discuss complications of leech therapy and their corresponding management measures. The majority of the relevant articles consist of case reports. Among these, 6 articles documented post-treatment infections (46 cases), 3 articles reported skin allergies (42 cases), 4 articles described prolonged bleeding (7 cases), and 3 articles cutaneous pseudolymphoma (4 cases), while 4 articles covered various other complications (4 cases). We have summarized the treatment approaches for these complications. Leech therapy, as a traditional medical approach, does offer certain benefits for specific conditions or symptoms. However, its administration should be conducted under the supervision of medical professionals. It's imperative to emphasize the prevention of complications and the implementation of appropriate treatment measures to enhance the safety of leech therapy. &nbsp

Local reactions to tick bites

A retrospective histological and immunohistochemical study has been carried out in 25 cases of tick bites recorded in our Departments. The samples that included an attached tick showed a cement cone anchoring the mouthparts to the skin and a blood-soaked, spongiform appearance of the superficial dermis, with a mild neutrophilic and eosinophilic infiltration. The vessels displayed a loose multilayered endothelial proliferation, with plump endothelia, permeated with erythrocytes. A few of them were severed, allowing copious blood extravasation. The established lesions included the following: erythema chronicum migrans-like cases, foreign body granulomas-sometimes containing remnants of the mouthparts-cutaneous lymphoid hyperplasia, either of the T-cell or the B-cell type, and tick-bite alopecia. In both the T-cell and B-cell pseudolymphomas, several vessels showed concentric endothelial and perithelial proliferation similar to that seen in the acute lesions. In the tick-bite alopecia, a lymphocytic infiltrate attacked the permanent portion of the hair follicles, whose reaction was a noticeable hyperplasia of the fibrous sheaths, although only a minority of the hairs was destroyed. The observed alterations are specific in the acute lesions and in the alopecia, where they directly arise as a result of the interactions between the host's tissues and the antihemostatic, anti-inflammatory, and immunomodulatory chemicals contained in the tick saliva. In the other lesions, the changes seem less characteristic, although the fragments of mouthparts and the special vascular changes provide a clue to their etiolog

Nódulos Cutâneos Eritematosos em Doente Residente na África Austral: Pseudolinfoma

The differential diagnosis of long-lasting erythematous skin nodules in patients living in Africa is broad. We report a clinical case of a 65-year-old Caucasian male, living in a Southern African Country, presenting to our department with an eight- -month history of erythematous skin nodules on the trunk and limbs. The diagnosis was B-pseudolymphoma and we discuss its aetiology and differential diagnosis.O diagnóstico diferencial de nódulos cutâneos eritematosos persistentes em África é vasto. Os autores reportam o caso clínico de um doente Caucasiano, sexo masculino, residente em país da África Austral, que recorreu à nossa consulta por nódulos eritematosos no tronco e membros com oito meses de evolução. O diagnóstico foi pseudolinfoma B e discute-se, neste artigo, o diagnóstico diferencial desta entidade

Forty years literature review of primary lung lymphoma

There are several unresolved issues through out the literature regarding the entity of primary lung lymphoma. Extensive literature review of this uncommon pathology is carried out