Neuro-electronic technology in medicine and beyond

This dissertation looks at the technology and social issues involved with interfacing electronics directly to the human nervous system, in particular the methods for both reading and stimulating nerves. The development and use of cochlea implants is discussed, and is compared with recent developments in artificial vision. The final sections consider a future for non-medicinal applications of neuro-electronic technology. Social attitudes towards use for both medicinal and non-medicinal purposes are discussed, and the viability of use in the latter case assessed

Tumor bed brachytherapy for locally advanced laryngeal cancer: a feasibility assessment of combination with ferromagnetic hyperthermia

Purpose. To assess the feasibility of adding hyperthermia to an original method of organ-preserving brachytherapy treatment for locally advanced head and neck tumors. Methods and materials. The method involves organ-preserving tumor resection and adjunctive high-dose-rate (HDR) brachytherapy delivered via afterloading catheters. These catheters are embedded in a polymeric implant prepared intraoperatively to fill the resection cavity, allowing precise computer planning of dose distribution in the surrounding at-risk tumor bed tissue. Theoretical and experimental analyzes address the feasibility of heating the tumor bed implant by coupling energy from a 100 kHz magnetic field applied externally into ferromagnetic particles, which are uniformly distributed within the implant. The goal is to combine adjuvant hyperthermia (40 °C–45 °C) to at-risk tissue within 5 mm of the resection cavity for thermal enhancement of radiation and chemotherapy response. Results. A five-year relapse free survival rate of 95.8% was obtained for a select group of 48 male patients with T3N0M0 larynx tumors, when combining organ-preserving surgery with HDR brachytherapy from a tumor bed implant. Anticipating the need for additional treatment in patients with more advanced disease, a theoretical analysis demonstrates the ability to heat at-risk tissue up to 10 mm from the surface of an implant filled with magnetically coupled ferromagnetic balls. Using a laboratory induction heating system, it takes just over 2 min to increase the target tissue temperature by 10 °C using a 19% volume fraction of ferromagnetic spheres in a 2 cm diameter silicone implant. Conclusion. The promising clinical results of a 48 patient pilot study demonstrate the feasibility of a new organ sparing treatment for laryngeal cancer. Anticipating the need for additional therapy, theoretical estimations of potential implant heating are confirmed with laboratory experiments, preparing the way for future implementation of a thermobrachytherapy implant approach for organ-sparing treatment of locally advanced laryngeal cancer

Future Needs for Tribo-Corrosion Research and Testing

Tribo-corrosion is an emerging interdisciplinary subject that spans from basic research on the behavior of surfaces in mechanical contact in chemically active surroundings to the test methods needed to quantify its effects, and from the selection of materials for bio-implants to the minimization of surface degradation and wastage in advanced energy conversion systems. Such a diverse field brings with it many challenges in understanding, testing, standardization, and application to engineering practice. This paper summarizes a panel discussion and participant survey held at the Third International Symposium on Tribo-Corrosion in Atlanta, Georgia, USA, in April 2012. It reflects a sense of agreement on many of the key scientific challenges in the field and the fact that tribo-corrosion is still in its infancy in terms of broad industry recognition, education, and the ability of those who conduct tribo-corrosion research to connect their laboratory results and theories to applications. Some sub-fields, notably the bio-tribo-corrosion of medical implants, have witnessed active international research efforts, but the engineering community in many other important areas of technology may not yet be aware of the field despite numerous tribo-corrosion problems that may exist within their purview

Naturalness and Neuronal Implants – Changes in the perception of human beings

With our contribution we would like to refer to the debate on nanotechnology (NT) and its implications for the public discourse on the relationship of human beings and technologies. Within NT the convergence of some technologies has been considered as a crucial step towards the long term objective of “enhancing human performance”. The discussion was initiated with an US-American workshop in the year 2002, where the innovative character of converging technology (CT) was strongly underlined (Roco 2002). In the final document of the workshop futuristic and far reaching scenarios on technical development based on NT and on CT were presented. First we address the implications of the mentioned document for research policy in general and especially of NT. Based on the example of neural implants we second qualify the normative expectations within the debate without however denying the helpfulness of these innovations especially in the field of medicine. But we third agree on a critical discussion, which consider a new quality of technological penetration into social and human processes.nanotechnology; innovation; converging technology; medicine; socio-economic implications

Osseointegrated prostheses for rehabilitation following amputation : The pioneering Swedish model.

The direct attachment of osseointegrated (OI) prostheses to the skeleton avoids the inherent problems of socket suspension. It also provides physiological weight bearing, improved range of motion in the proximal joint, as well as osseoperceptive sensory feedback, enabling better control of the artificial limbs by amputees. The present article briefly reviews the pioneering efforts on extremity osseointegration surgeries in Sweden and the development of the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) program. The standard implant design of the OPRA system and surgical techniques are described as well as the special rehabilitation protocols based on surgical sites. The results of long-term follow-up for transradial, transhumeral, and thumb amputee operations are briefly reported including the prospective study of transfemoral amputees according to OPRA protocol. The importance of refinement on implant designs and surgical techniques based on the biomechanical analysis and early clinical trials is emphasized. Future aspects on osseointegration surgery are briefly described, including novel treatment options using implanted electrodes

Simulation of ion track ranges in uranium oxide

Direct comparisons between statistically sound simulations of ion-tracks and published experimental measurements of range densities of iodine implants in uranium dioxide have been made with implant energies in the range of 100-800 keV. Our simulations are conducted with REED-MD (Rare Event Enhanced Domain-following Molecular Dynamics) in order to account for the materials structure in both single crystalline and polycrystalline experimental samples. We find near-perfect agreement between REED-MD results and experiments for polycrystalline target materials.Comment: Eleven pages, four figures

Ionizing radiation effects on CMOS imagers manufactured in deep submicron process

We present here a study on both CMOS sensors and elementary structures (photodiodes and in-pixel MOSFETs) manufactured in a deep submicron process dedicated to imaging. We designed a test chip made of one 128×128-3T-pixel array with 10 µm pitch and more than 120 isolated test structures including photodiodes and MOSFETs with various implants and different sizes. All these devices were exposed to ionizing radiation up to 100 krad and their responses were correlated to identify the CMOS sensor weaknesses. Characterizations in darkness and under illumination demonstrated that dark current increase is the major sensor degradation. Shallow trench isolation was identified to be responsible for this degradation as it increases the number of generation centers in photodiode depletion regions. Consequences on hardness assurance and hardening-by-design are discussed

Influence of dislocation loops on the near infrared light emission from silicon diodes

The infrared light emission of forward-biased silicon diodes is studied. Through ion implantation and anneal, dislocation loops were created near the diode junction. These loops suppress the light emission at the band-to-band peak around 1.1 μm. The so-called D1 line at 1.5 μm is strongly enhanced by these dislocation loops. We report a full study of photoluminescence and electroluminescence of these diodes. The results lead to new insights for the manufacturing approach of practical infrared light sources in integrated circuit