Supporting transient stability in future highly distributed power systems

Incorporating a substantial volume of microgeneration (consumer-led rather than centrally planed) within a system that is not designed for such a paradigm could lead to conflicts in the operating strategies of the new and existing centralised generation technologies. So it becomes vital for such substantial amounts of microgeneration among other decentralised resources to be controlled in the way that the aggregated response will support the wider system. In addition, the characteristic behaviour of such populations requires to be understood under different system conditions to ascertain measures of risk and resilience. Therefore, this paper provides two main contributions: firstly, conceptual control for a system incorporating a high penetration of microgeneration and dynamic load, termed a Highly Distributed Power System (HDPS), is proposed. Secondly, a technical solution that can support enhanced transient stability in such a system is evaluated and demonstrated

Encounter complexes and dimensionality reduction in protein-protein association

An outstanding challenge has been to understand the mechanism whereby proteins associate. We report here the results of exhaustively sampling the conformational space in protein–protein association using a physics-based energy function. The agreement between experimental intermolecular paramagnetic relaxation enhancement (PRE) data and the PRE profiles calculated from the docked structures shows that the method captures both specific and non-specific encounter complexes. To explore the energy landscape in the vicinity of the native structure, the nonlinear manifold describing the relative orientation of two solid bodies is projected onto a Euclidean space in which the shape of low energy regions is studied by principal component analysis. Results show that the energy surface is canyon-like, with a smooth funnel within a two dimensional subspace capturing over 75% of the total motion. Thus, proteins tend to associate along preferred pathways, similar to sliding of a protein along DNA in the process of protein-DNA recognition

CHO microRNA engineering is growing up : recent successes and future challenges

microRNAs with their ability to regulate complex pathways that control cellular behavior and phenotype have been proposed as potential targets for cell engineering in the context of optimization of biopharmaceutical production cell lines, specifically of Chinese Hamster Ovary cells. However, until recently, research was limited by a lack of genomic sequence information on this industrially important cell line. With the publication of the genomic sequence and other relevant data sets for CHO cells since 2011, the doors have been opened for an improved understanding of CHO cell physiology and for the development of the necessary tools for novel engineering strategies. In the present review we discuss both knowledge on the regulatory mechanisms of microRNAs obtained from other biological models and proof of concepts already performed on CHO cells, thus providing an outlook of potential applications of microRNA engineering in production cell lines

Experimental investigation on synthesis, characterization, stability, thermo-physical properties and rheological behavior of MWCNTs-kapok seed oil based nanofluid

Several researchers devoted their efforts for the thermal conductivity enhancement of Carbon Nanotubes (CNTs) based nanofluids as CNTs have excellent thermal properties. However, limited research is reported on the detailed thermo-physical properties of CNTs and oil based nanofluids. In this work, the one-step method synthesis of a new MWCNTs-Kapok seed oil based nanofluid at constant nanoparticle concentration (0.1 wt./wt.) is reported. The nanofluid is characterized by FESEM, FTIR, visual stability analysis and thermophysical properties are experimentally measured. The viscosity found in the range of (0.049–10.101¿Pa·s), the thermal conductivity of (0.165–0.207¿W/m·K) and enhancement of thermal conductivity (6.1538%) were observed. Moreover, the viscosity decreases, and thermal conductivity increases with an increase in temperature. The experimentally obtained data are found in agreement with existing models and modified correlations. The rheological behavior showed that nanofluid is non-Newtonian in nature and exhibiting shear thinning or pseudo plastic behavior.Preprin

Modeling of Electrokinetic Remediation Combining Local Chemical Equilibrium and Chemical Reaction Kinetics

A mathematical model for reactive-transport processes in porous media is presented. The modeled system includes diffusion, electromigration and electroosmosis as the most relevant transport mechanism and water electrolysis at the electrodes, aqueous species complexation, precipitation and dissolution as the chemical reactions taken place during the treatment time. The model is based on the local chemical equilibrium for most of the reversible chemical reactions occurring in the process. As a novel enhancement of previous models, the local chemical equilibrium reactive-transport model is combined with the solution of the transient equations for the kinetics of those chemical reactions that have representative rates in the same order than the transport mechanisms. The model is validated by comparison of simulation and experimental results for an acid- enhanced electrokinetic treatment of a real Pb-contaminated calcareous soil. The kinetics of the main pH buffering process, the calcite dissolution, was defined by a simplified empirical kinetic law. Results show that the evaluation of kinetic rate entails a significant improvement of the model prediction capability.This work has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 778045. Part of this work was supported financially by the European Commission within the project LIFE12 ENV/IT/442 SEKRET “Sediment electrokinetic remediation technology for heavy metal pollution removal”. Paz-Garcia acknowledges the financial support from the “Proyecto Puente - Plan Propio de Investigación y Transferencia de la Universidad de Málaga”, code: PPIT.UMA.B5.2018/17. Villen-Guzman acknowledges the financial support from the University of Malaga through a postdoctoral contract