A generalized nonstandard finite difference method for a class of autonomous dynamical systems and its applications

In this work, a class of continuous-time autonomous dynamical systems describing many important phenomena and processes arising in real-world applications is considered. We apply the nonstandard finite difference (NSFD) methodology proposed by Mickens to design a generalized NSFD method for the dynamical system models under consideration. This method is constructed based on a novel non-local approximation for the right-side functions of the dynamical systems. It is proved by rigorous mathematical analyses that the NSFD method is dynamically consistent with respect to positivity, asymptotic stability and three classes of conservation laws, including direct conservation, generalized conservation and sub-conservation laws. Furthermore, the NSFD method is easy to be implemented and can be applied to solve a broad range of mathematical models arising in real-life. Finally, a set of numerical experiments is performed to illustrate the theoretical findings and to show advantages of the proposed NSFD method.Comment: 29 pages, 5 figure

Differential Models, Numerical Simulations and Applications

This Special Issue includes 12 high-quality articles containing original research findings in the fields of differential and integro-differential models, numerical methods and efficient algorithms for parameter estimation in inverse problems, with applications to biology, biomedicine, land degradation, traffic flows problems, and manufacturing systems

Mathematical Modeling of Biological Systems

Mathematical modeling is a powerful approach supporting the investigation of open problems in natural sciences, in particular physics, biology and medicine. Applied mathematics allows to translate the available information about real-world phenomena into mathematical objects and concepts. Mathematical models are useful descriptive tools that allow to gather the salient aspects of complex biological systems along with their fundamental governing laws, by elucidating the system behavior in time and space, also evidencing symmetry, or symmetry breaking, in geometry and morphology. Additionally, mathematical models are useful predictive tools able to reliably forecast the future system evolution or its response to specific inputs. More importantly, concerning biomedical systems, such models can even become prescriptive tools, allowing effective, sometimes optimal, intervention strategies for the treatment and control of pathological states to be planned. The application of mathematical physics, nonlinear analysis, systems and control theory to the study of biological and medical systems results in the formulation of new challenging problems for the scientific community. This Special Issue includes innovative contributions of experienced researchers in the field of mathematical modelling applied to biology and medicine

Differential Equation Models in Applied Mathematics

The present book contains the articles published in the Special Issue “Differential Equation Models in Applied Mathematics: Theoretical and Numerical Challenges” of the MDPI journal Mathematics. The Special Issue aimed to highlight old and new challenges in the formulation, solution, understanding, and interpretation of models of differential equations (DEs) in different real world applications. The technical topics covered in the seven articles published in this book include: asymptotic properties of high order nonlinear DEs, analysis of backward bifurcation, and stability analysis of fractional-order differential systems. Models oriented to real applications consider the chemotactic between cell species, the mechanism of on-off intermittency in food chain models, and the occurrence of hysteresis in marketing. Numerical aspects deal with the preservation of mass and positivity and the efficient solution of Boundary Value Problems (BVPs) for optimal control problems. I hope that this collection will be useful for those working in the area of modelling real-word applications through differential equations and those who care about an accurate numerical approximation of their solutions. The reading is also addressed to those willing to become familiar with differential equations which, due to their predictive abilities, represent the main mathematical tool for applying scenario analysis to our changing world

Models of Delay Differential Equations

This book gathers a number of selected contributions aimed at providing a balanced picture of the main research lines in the realm of delay differential equations and their applications to mathematical modelling. The contributions have been carefully selected so that they cover interesting theoretical and practical analysis performed in the deterministic and the stochastic settings. The reader will find a complete overview of recent advances in ordinary and partial delay differential equations with applications in other multidisciplinary areas such as Finance, Epidemiology or Engineerin

Advanced numerical treatment of chemotaxis driven PDEs in mathematical biology

From the first formulation of chemotaxis-driven partial differential equations (PDEs) by Keller and Segel in the 1970's up to the present, much effort has been expended in modelling complex chemotaxis re- lated processes. The shear complexity of such resulting PDEs crucially limits the postulation of analytical results. In this context the sup- port by numerical tools are of utmost interest and, thus, render the implementation of a numerically well elaborated solver an undoubt- edly important task. In this work I present different iteration strategies (linear/nonlinear, decoupled/monolithic) for chemotaxis-driven PDEs. The discretiza- tion follows the method of lines, where I employ finite elements to resolve the spatial discretization. I extensively study the numerical efficiency of the iteration strategies by applying them on particular chemotaxis models. Moreover, I demonstrate the need of numerical stabilization of chemotaxis-driven PDEs and apply a exible scalar algebraic ux correction. This methodology preserves the positivity of the fully discretized scheme under mild conditions and renders the numerical solution non-oscillatory at a low level of additional compu- tational costs. This work provides a first detailed study of accurate, efficient and exible finite element schemes for chemotaxis-driven PDEs and the implemented numerical framework provides a valuable basis for fu- ture applications of the solvers to more complex models

New Advancements in Pure and Applied Mathematics via Fractals and Fractional Calculus

This reprint focuses on exploring new developments in both pure and applied mathematics as a result of fractional behaviour. It covers the range of ongoing activities in the context of fractional calculus by offering alternate viewpoints, workable solutions, new derivatives, and methods to solve real-world problems. It is impossible to deny that fractional behaviour exists in nature. Any phenomenon that has a pulse, rhythm, or pattern appears to be a fractal. The 17 papers that were published and are part of this volume provide credence to that claim. A variety of topics illustrate the use of fractional calculus in a range of disciplines and offer sufficient coverage to pique every reader's attention