Plasmonic Copper Polyhedral Particle에 의한 간단하고 신속한 샌드위치 면역분석 플랫폼

학위논문(석사) -- 서울대학교대학원 : 자연과학대학 화학부, 2021.8. 남좌민.Over the years there has been an ever-growing demand for a rapid and simple immunoassay system years. To acknowledge this need several colorimetric immunosensors which utilize plasmon nanoparticles have been proposed in recent years. However, there are issues which must be addressed, such as the time required for the catalytic reaction, and the possibility of being affected by the external environment. To overcome the temporal limitations, homogeneous-plasmonic copper polyhedral nano-shell were grown on gold nanoparticle probes. These nanoparticles scatter in such an efficient manner that light can be photographed and quantified by mobile phones. By using this method we provide a highly sensitive and quick detectable immunoassay system. Initially, the prostate specific antigen was chosen as the standard target, and its measurement had a 4-digit dynamic range with a total assay time of 15 minutes and a lower detection limit of 50 pg/mL (1.5 pM, 6 attomole). Furthermore, we have developed a method to simultaneously identify and quantify two inflammatory biomarkers (C - reactive protein and Procalcitonin) by dots pattern in one sample. This method suggests the possibility of providing a platform that can detect and quantify multiple biomarkers in an efficient manner.수년에 걸쳐 신속하고 간단한 면역분석 시스템에 대한 수요가 계속 증가해 왔습니다. 이를 인정하기 위해 최근 몇 년 동안 플라스몬 나노입자를 활용하는 여러 비색 면역센서가 제안되었습니다. 그러나 촉매반응에 소요되는 시간과 외부환경의 영향을 받을 가능성 등 해결해야 할 문제가 있다. 시간적 한계를 극복하기 위해 균질 플라즈몬 구리 다면체 나노 쉘을 금 나노 입자 프로브에서 성장 시켰습니다. 이러한 나노 입자는 빛을 휴대폰으로 촬영하고 정량화할 수 있을 정도로 효율적인 방식으로 산란됩니다. 이 방법을 사용하여 우리는 매우 민감하고 빠른 감지 가능한 면역 분석 시스템을 제공합니다. 처음에는 전립선 특이적 항원이 표준 표적으로 선택되었으며, 이의 측정은 총 분석 시간이 15분이고 검출 하한이 50pg/mL(1.5pM, 6 attomole)인 4자리 동적 범위를 가졌습니다. 또한 하나의 샘플에서 점 패턴으로 두 개의 염증성 바이오마커(C - 반응성 단백질 및 Procalcitonin)를 동시에 식별하고 정량화하는 방법을 개발했습니다. 이 방법은 여러 바이오마커를 효율적으로 검출하고 정량화할 수 있는 플랫폼을 제공할 수 있는 가능성을 제시합니다.1. Introduction 1 2. Experimental Section 4 3. Results and Dscussion 10 4. Conclusion 16 5. References 30 Abstract in Korean 33석

Increasing Light Absorption and Collection Using Engineered Structures

In recent years we have witnessed an explosion of interest in two dimensional (2D) materials, due to their unique physical properties. Excitement surrounds the promise of replacing conventional bulk photodetectors with devices based on 2D materials, allowing better integration, flexibility and potentially improving performance. However, the low inherent light absorption of 2D materials is an outstanding issue to be solved. In this chapter we review two independent approaches to tackling this problem, which have the potential to be combined to find a robust solution. The first approach involves patterning the substrate with a rod-type photonic crystal (PhC) cavity structure, which is shown to increase the light absorption into a 2D material flake coupled spatially to the cavity mode. Secondly, we review 2D–compatible solid immersion lenses (SILs) and their ability to increase both the optical magnification of the structures they encapsulate, and the longevity of the material. SILs have been shown to reduce the requirements for complex optics in the implementation of 2D materials in optoelectronic devices, and also in preserving the photodetector’s optical performance over long periods of time. Finally, we show how by combining rod-type PhC cavities with SILs, we can improve the performance of 2D material-based photodetectors

Nanoengineered Functional Structures for Photonic and Microfluidic Applications

Owing to their extraordinary ability to interacting with external stimuli as well as their versatile functionalities hardly observed in bulk systems, micro- and nano-scale materials, structures, and phenomena have been the subject of increasing interest from both academia and industry. Many diverse fields including optoelectronics, photonics, bioengineering, and energy conversion have all shown significant increases in utilization of, and need for, micro/nano-scale features. To meet this demand, not only novel manufacturing methodologies, but also underlying physics and design principles are called for. This thesis work addresses these issues while focusing on three main topics: (1) how certain fundamental nanostructures such as periodic nanopatterned surface, multilayers and charged particle-line can be utilized as functional building blocks for multidisciplinary applications ranging from nanoparticle/biomolecule manipulation to optoelectronics/photonics; (2) how these functional nanoarchitectures can be engineered in a continuous and scalable manner to increase the manufacturing throughput; and (3) the underlying physics and the design principles of these nanostructures in particular application systems. More specifically, large area, 1D/2D periodic sinusoidal nanopatterned surface based on Dynamic Nano-inscribing (DNI) patterning technique is developed. And its applications to nanoparticle assembly/sorting and light extraction from GaN LED are investigated. By exploiting this sinusoidal nanovoid pattern and geometry-dependent ionic entropy, we successfully realized the size-selectively confinement and patterning of submicron-sized particles over a large area. Moreover, general method of light extraction from trapped modes by using these 1D/2D sinusoidal nanogratings have been developed. We applied our method to flip-chip GaN LED and a further enhancement of the total radiative power in addition to the PSS structures have been observed. Metal/dielectric multilayer structures are widely used as fundamental building blocks for photonic crystal/metamaterials, color filters and anti-reflection coatings. Here in this work, we are focus on the applications of metal/dielectric multilayers on hyperbolic metamaterials (HMM) and surface-plasmon-coupled light emission from 2D materials and organic light emission materials. For hyperbolic metamaterials, we show that by using thin (~7nm) Al doped Ag metal films, we can dramatically improve the performance as well as the photon density of state (DOS) of the HMM. However, a further discussion on the nonlocal response of electrons in ultrathin (sub-1nm) metal films have been conducted and shows that the nonlocality induced by quantum effects of electrons (degeneracy pressure, diffusion kinetics and tunneling) can dramatically induce the transitions of the photonic topology of the metamaterials and intrinsically limit the DOS. Metal/dielectrics multilayers are also used to study the exciton-plasmon energy transfer and surface plasmon coupled light emission from 2D semi-conductors (WSe2) and organic light emission materials (Super Yellow). Based on one optimized planar multilayer structure we observed an 8 times enhancement of the PL signal. And we applied this concept to OLED structure, enhancement of the efficiency were also observed from SY-based OLEDs.PHDApplied PhysicsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/137153/1/lonchen_1.pd

Integrated optical components for quantum key distribution

The security of current public key cryptosystems, such as RSA, depends on the difficulty of computing certain functions known as trapdoor functions. However, as computational resources become more abundant with the fast development of super- and quantum computers, relying on such methods for communication security becomes risky. Quantum key distribution (QKD), is a potential solution that can allow theoretically secure key exchange for future communications. Chip-scale integration of this solution for securing communication of embedded systems and hand held devices demands miniaturizing the optical components that are used in typical QKD boxes, hence reducing its size and cost. The aim of the work in this thesis is firstly investigating novel approaches to realising integrable single photon sources and detectors for applications such as QKD, and secondly proposing a chip-scale integrated QKD system with efficient and optimised optical components. In the first part of the thesis, a model for coupling 2D material emitters to rod-type photonic cavities is studied for room temperature single photon sources. Our investigated approach allows better coupling between the emitter and the cavity modes than conventional methods, while increasing light collection ratio. In the second part, site-controlled growth of semiconductor III-V nanowires on Si for photodetection applications is achieved by fabricating the sites using electron-beam lithography and wet etching. Studies were also carried out to investigate the effect of the wafer’s growth temperature on the nanowire formation. Finally, a model was proposed for realising a chip-scale QKD system using photonic crystals as a photonic circuit platform. The work involves increasing the Q-factor of the cavity single photon source, increasing cavity waveguide coupling, reducing losses in beam splitters and out-couplers. A final model of a chip-scale QKD system which involves the optimised components is proposed at the end of the thesis

Sistemas híbridos basados en grafeno y MoS2-2D para detección óptica

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Física de Materiales. Fecha de Lectura: 02-12-202