Continuous manufacturing and product-process archetypes: implications for supply network design in Pharma

Continuous Manufacturing has enabled the potential for significant step changes within the Pharmaceutical industry. However, adoption rates remain in the range of 5%. This research examines the challenges and implications of the shift from ‘batch’ to ‘continuous’ processing in terms of e.g. product variety and supply network design

Urban Regeneration of Industrial Areas: Affordable Housing for Low Income Populations in Cities

The UK-China Sustainable Development Dialogue (SDD) is a partnership between the UK and Chinese Governments to promote collaboration and good practice on sustainable development. It is framed by a 2004 joint Prime Ministerial declaration and was formally established in 2005 by an agreement signed by UK Deputy Prime Minister John Prescott and State Councillor Tang. The SDD was founded on the recognition that, in an interdependent world, international co-operation is needed to ensure that learning is shared and efforts are made collectively towards achieving common goals. This report is the 13th and Final Paper in the SDD (Urban Strand. It draws together the core conclusions from the previous twelve papers and offers recommendations for taking the dialogue forward

Multivariate Analysis in Management, Engineering and the Sciences

Recently statistical knowledge has become an important requirement and occupies a prominent position in the exercise of various professions. In the real world, the processes have a large volume of data and are naturally multivariate and as such, require a proper treatment. For these conditions it is difficult or practically impossible to use methods of univariate statistics. The wide application of multivariate techniques and the need to spread them more fully in the academic and the business justify the creation of this book. The objective is to demonstrate interdisciplinary applications to identify patterns, trends, association sand dependencies, in the areas of Management, Engineering and Sciences. The book is addressed to both practicing professionals and researchers in the field

Globalizing the firm through projects : The Case of Renault

Over the past decade, the automotive industry has been the arena of concentration and globalization of firms. While strategies aiming to attain a critical mass through external growth and international expansion programs are not new in this sector, the magnitude and global extent of this movement have reached an unprecedented level during the 1990's. Although this trend would apparently seem homogeneous and guided by a kind of fashion phenomena, a fine-grained analysis of the dynamics of today's firms reveals, instead, a significant variety of patterns. Since the globalization of a firm is just one attribute of its complex identity associating different dimensions, it raises some important questions. How will the globalization issue be articulated with the other key dimensions of a firm? How will this development axis be integrated with the firm's own traditions? In the same way that typologies of organisations have been identified, is it possible to characterise both the diversity of globalization processes and the firm's globalization model? This paper aims to address these questions by analysing the Renault case. Firstly, we provide a conceptual framework based upon organisational learning theories to explain the dynamics of the firm. Secondly, we argue that four globalization trajectories should be distinguished: the traditional model based on the dominant market, globalization through projects, functional lines and platforms. Each trajectory will be described and compared. Finally, in the last section, we illustrate the globalization trajectory through projects with intermediate results of an ongoing research on the Renault and GME partnership for the joint development of a new light commercial vehicle. Using interactive-research methods, the aim of this research is to experiment several organisational devices in order to develop and promote collective competencies in the management of international co-operative projects, throughout the organisation. We conclude by giving some managerial implication of our findings and directions for further research

Characterisation of amorphous pharmaceutical materials

Small quantities of amorphous content can have a profound influence on the properties of a material, however their instability means that quantifying amorphous content over time is important for proving the stability of a drug. Quantifying amorphous content in α-lactose monohydrate by solid state 13C CP MAS NMR, has been carried out by use of proton saturation recovery relaxation and differentiating between spectra by partial least squares (PLS), however these techniques have not proved sensitive on their own, this work investigates their sensitivity in combination. Crystalline α-lactose monohydrate and a rapidly quenched melt were combined to create a set of calibration mixes, whose spectra were recorded using proton saturation recovery relaxations ranging from 2 to 60 seconds. This technique showed a limit of detection of 0.17% (LOD = intercept + 3xSy/x), with a relaxation delay of 15 s and was able to recognise amorphous materials generated by spray and freeze drying. The atmospheric effects on the proton saturation recovery relaxation times of different amorphous lactose preparations were investigated. This found that an oxygen atmosphere reduced the relaxation times, of amorphous lactose that was prepared from a rapidly quenched melt. The loss of moisture from spray dried and freeze dried samples to less than 1% removed the significance of this effect. Lactose is an important excipient in pharmaceuticals and a key ingredient of confectionary, very little research has been carried out in to the quantification of the isomers of different preparations of amorphous lactose. This work quantifies the isomer content by Gas Chromatography with Flame Ionisation Detection (GC-FID) using a DB-17 15m 0.53mm 1.00 μm column and derivatisation with N- (trimethylsilyl)imidazole. [Continues.

Principal Component Analysis

This book is aimed at raising awareness of researchers, scientists and engineers on the benefits of Principal Component Analysis (PCA) in data analysis. In this book, the reader will find the applications of PCA in fields such as taxonomy, biology, pharmacy,finance, agriculture, ecology, health and architecture

Biotechnology in Europe and Latin America: prospects for co-operation

The materials presented at the conference have been updated and edited, to give in this book an up-to-date picture of capabilities and common IV interests. Although inevitably any book on biotechnology is obsolete by the time it appears, there is nothing obsolescent about the dynamism now being displayed in the development of the bioindustries in both continents. We hope that the presentations assembled in this volume will testify to this dynamic development, and stimulate its further promotion. [excerpt taken from the book's Preface

Modeling Industrial Lot Sizing Problems: A Review

In this paper we give an overview of recent developments in the field of modeling single-level dynamic lot sizing problems. The focus of this paper is on the modeling various industrial extensions and not on the solution approaches. The timeliness of such a review stems from the growing industry need to solve more realistic and comprehensive production planning problems. First, several different basic lot sizing problems are defined. Many extensions of these problems have been proposed and the research basically expands in two opposite directions. The first line of research focuses on modeling the operational aspects in more detail. The discussion is organized around five aspects: the set ups, the characteristics of the production process, the inventory, demand side and rolling horizon. The second direction is towards more tactical and strategic models in which the lot sizing problem is a core substructure, such as integrated production-distribution planning or supplier selection. Recent advances in both directions are discussed. Finally, we give some concluding remarks and point out interesting areas for future research