2,870,709 research outputs found

    Non-LTE line formation for Pr II and Pr III in A and Ap stars

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    Non-LTE line formation for Pr II and Pr III is considered through a range of effective temperatures between 7250 K and 9500 K. A comprehensive model atom for Pr II/III is based on the measured and the predicted energy levels, in total, 6708 levels of Pr II and Pr III. We describe calculations of the Pr II energy levels and oscillator strengths for the transitions in Pr II and Pr III. The influence of departures from LTE on Pr abundance determinations is evaluated. At Teff >= 8000 K departures from LTE lead to overionization of Pr II and to systematically depleted total absorption in the line and positive abundance corrections. At the lower temperatures, different lines of Pr II may be either weakened or amplified depending on the line strength. The non-LTE effects strengthen the Pr III lines and lead to negative abundance corrections. Non-LTE corrections grow with effective temperature for the Pr II lines, and, in contrast, they decline for the Pr III lines. The Pr II/III model atom is applied to determine the Pr abundance in the atmosphere of the roAp star HD 24712 from the lines of two ionization stages. In the chemically uniform atmosphere with [Pr/H] = 3, the departures from LTE may explain only small part (0.3 dex) of the difference between the LTE abundances derived from the Pr II and Pr III lines (2 dex). We find that the lines of both ionization stages are described for the vertical distribution of the praseodymium where the Pr enriched layer with [Pr/H] > 4 exists in the outer atmosphere at log tau_5000 < -4. The departures from LTE for Pr II/III are strong in the stratified atmosphere and have the opposite sign for the Pr II and Pr III lines. Using the revised partition function of Pr II and experimental transition probabilities, we determine the solar non-LTE abundance of Pr as log (Pr/H) = -11.15\pm0.08.Comment: 17 pages, 4 tables, 11 figures, accepted for publication in A&

    The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent

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    Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study, proteins from female mouse hypothalamus that associate with PR were isolated using affinity pull-down assays with glutathione S-transferase–tagged mouse PR-A and PR-B. Using complementary proteomics approaches, reverse phase protein array (RPPA) and mass spectrometry, we identified hypothalamic proteins that interact with PR in a ligand-dependent and isoform-specific manner and were confirmed by Western blot. Synaptic proteins, including synapsin-I and synapsin-II, interacted with agonist-bound PR isoforms, suggesting that both isoforms function in synaptic plasticity. In further support, synaptogyrin-III and synapsin-III associated with PR-A and PR-B, respectively. PR also interacted with kinases, including c-Src, mTOR, and MAPK1, confirming phosphorylation as an integral process in rapid effects of PR in the brain. Consistent with a role in transcriptional regulation, PR associated with transcription factors and coactivators in a ligand-specific and isoform-dependent manner. Interestingly, both PR isoforms associated with a key regulator of energy homeostasis, FoxO1, suggesting a novel role for PR in energy metabolism. Because many identified proteins in this PR interactome are synaptic proteins, we tested the hypothesis that progestins function in synaptic plasticity. Indeed, progesterone enhanced synaptic density, by increasing synapsin-I–positive synapses, in rat primary cortical neuronal cultures. This novel combination of RPPA and mass spectrometry allowed identification of PR action in synaptic remodeling and energy homeostasis and reveals unique roles for progestins in brain function and disease

    Analytical shock solutions at large and small Prandtl number

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    Exact one-dimensional solutions to the equations of fluid dynamics are derived in the large-Pr and small-Pr limits (where Pr is the Prandtl number). The solutions are analogous to the Pr = 3/4 solution discovered by Becker and analytically capture the profile of shock fronts in ideal gases. The large-Pr solution is very similar to Becker's solution, differing only by a scale factor. The small-Pr solution is qualitatively different, with an embedded isothermal shock occurring above a critical Mach number. Solutions are derived for constant viscosity and conductivity as well as for the case in which conduction is provided by a radiation field. For a completely general density- and temperature-dependent viscosity and conductivity, the system of equations in all three limits can be reduced to quadrature. The maximum error in the analytical solutions when compared to a numerical integration of the finite-Pr equations is O(1/Pr) for large Pr and O(Pr) for small Pr.Comment: 11 pages, 6 figures. Accepted for publication in Journal of Fluid Mechanics Rapid

    On vv--domains and star operations

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    Let ∗\ast be a star operation on an integral domain DD. Let \f(D) be the set of all nonzero finitely generated fractional ideals of DD. Call DD a ∗\ast--Pr\"ufer (respectively, (∗,v)(\ast, v)--Pr\"ufer) domain if (FF−1)∗=D(FF^{-1})^{\ast}=D (respectively, (FvF−1)∗=D(F^vF^{-1})^{\ast}=D) for all F\in \f(D). We establish that ∗\ast--Pr\"ufer domains (and (∗,v)(\ast, v)--Pr\"ufer domains) for various star operations ∗\ast span a major portion of the known generalizations of Pr\"{u}fer domains inside the class of vv--domains. We also use Theorem 6.6 of the Larsen and McCarthy book [Multiplicative Theory of Ideals, Academic Press, New York--London, 1971], which gives several equivalent conditions for an integral domain to be a Pr\"ufer domain, as a model, and we show which statements of that theorem on Pr\"ufer domains can be generalized in a natural way and proved for ∗\ast--Pr\"ufer domains, and which cannot be. We also show that in a ∗\ast --Pr\"ufer domain, each pair of ∗\ast -invertible ∗\ast -ideals admits a GCD in the set of ∗\ast -invertible ∗\ast -ideals, obtaining a remarkable generalization of a property holding for the "classical" class of Pr\"ufer vv--multiplication domains. We also link DD being ∗\ast --Pr\"ufer (or (∗,v)(\ast, v)--Pr\"ufer) with the group Inv∗(D)^{\ast}(D) of ∗\ast -invertible ∗\ast -ideals (under ∗\ast-multiplication) being lattice-ordered

    Nature of the low temperature ordering of Pr in PrBa_2Cu_3O_(6+x)

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    Theoretical model is presented to describe the anomalous ordered phase of Pr ions in PrBa_2Cu_3O_(6+x) below T_Pr = 12-17 K. The model considers the Pr multipole degrees of freedom and coupling between the Cu and Pr subsystems. We identify the symmetry allowed coupling of Cu and Pr ions and conclude that only an ab-plane Pr dipole ordering can explain the Cu spin rotation observed at T_Pr by neutron diffraction by Boothroyd et al. [A. T. Boothroyd et al., Phys. Rev. Lett. 78, 130 (1997)]. A substantial enhancement of the Pr ordering temperature is shown to arise from the Cu-Pr coupling which is the key for the anomalous magnetic behavior in PrBa_2Cu_3O_(6+x).Comment: 6 pages, 4 figure

    Photoreactivation of Lethal Damage Induced in Hamster X Xenopus Hybrid Cells and Their Parentals by UV Light

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    A85 Xenopus cells that exhibited a high level of photoreactivation (PR) and V79B2 hamster cells that exhibited little PR were fused to produce the V79B2 x A85 cell line — a hybrid line which possessed a relatively stable karyotype, with most cells containing the entire V79B2 and A85 genomes. UV and UV plus PR fluence-survival relations were then determined and compared for the hybrid and parental lines in a first attempt to elucidate interactions of the parental PR mechanisms in the hybrid. It was anticipated that the A85 genome in the hybrid would produce PR enzyme in sufficient concentration and of such a nature as to efficiently PR UV-induced lethal damage in both A85 and V79B2 DNA, and little difference would be observed in the levels of PR exhibited by the V79B2 x A85 and A85 lines. To the contrary, the level of PR observed for the hybrid was substantially below that observed for the A85 line. To assist in the interpretation of this unexpected observation, three additional preliminary studies were carried out: 1) Comparison of the optimum PR schemes for the A85 and hybrid lines, 2) examination of relations between the PR and dark UV repair mechanisms possessed by these lines, and 3) comparison of the levels of PR of chromatid deletions induced by UV in selected V79B2 and A85 chromosomes of the hybrid. The results suggested that the relatively low level of PR manifested by the hybrid cells was a consequence of their inability to efficiently PR pyrimidine dimers induced by UV in V79B2 DNA
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