14,923 research outputs found
A roadmap to integrate astrocytes into Systems Neuroscience.
Systems neuroscience is still mainly a neuronal field, despite the plethora of evidence supporting the fact that astrocytes modulate local neural circuits, networks, and complex behaviors. In this article, we sought to identify which types of studies are necessary to establish whether astrocytes, beyond their well-documented homeostatic and metabolic functions, perform computations implementing mathematical algorithms that sub-serve coding and higher-brain functions. First, we reviewed Systems-like studies that include astrocytes in order to identify computational operations that these cells may perform, using Ca2+ transients as their encoding language. The analysis suggests that astrocytes may carry out canonical computations in a time scale of subseconds to seconds in sensory processing, neuromodulation, brain state, memory formation, fear, and complex homeostatic reflexes. Next, we propose a list of actions to gain insight into the outstanding question of which variables are encoded by such computations. The application of statistical analyses based on machine learning, such as dimensionality reduction and decoding in the context of complex behaviors, combined with connectomics of astrocyte-neuronal circuits, is, in our view, fundamental undertakings. We also discuss technical and analytical approaches to study neuronal and astrocytic populations simultaneously, and the inclusion of astrocytes in advanced modeling of neural circuits, as well as in theories currently under exploration such as predictive coding and energy-efficient coding. Clarifying the relationship between astrocytic Ca2+ and brain coding may represent a leap forward toward novel approaches in the study of astrocytes in health and disease
An Advanced Conceptual Diagnostic Healthcare Framework for Diabetes and Cardiovascular Disorders
The data mining along with emerging computing techniques have astonishingly
influenced the healthcare industry. Researchers have used different Data Mining
and Internet of Things (IoT) for enrooting a programmed solution for diabetes
and heart patients. However, still, more advanced and united solution is needed
that can offer a therapeutic opinion to individual diabetic and cardio
patients. Therefore, here, a smart data mining and IoT (SMDIoT) based advanced
healthcare system for proficient diabetes and cardiovascular diseases have been
proposed. The hybridization of data mining and IoT with other emerging
computing techniques is supposed to give an effective and economical solution
to diabetes and cardio patients. SMDIoT hybridized the ideas of data mining,
Internet of Things, chatbots, contextual entity search (CES), bio-sensors,
semantic analysis and granular computing (GC). The bio-sensors of the proposed
system assist in getting the current and precise status of the concerned
patients so that in case of an emergency, the needful medical assistance can be
provided. The novelty lies in the hybrid framework and the adequate support of
chatbots, granular computing, context entity search and semantic analysis. The
practical implementation of this system is very challenging and costly.
However, it appears to be more operative and economical solution for diabetes
and cardio patients.Comment: 11 PAGE
Lesion detection and Grading of Diabetic Retinopathy via Two-stages Deep Convolutional Neural Networks
We propose an automatic diabetic retinopathy (DR) analysis algorithm based on
two-stages deep convolutional neural networks (DCNN). Compared to existing
DCNN-based DR detection methods, the proposed algorithm have the following
advantages: (1) Our method can point out the location and type of lesions in
the fundus images, as well as giving the severity grades of DR. Moreover, since
retina lesions and DR severity appear with different scales in fundus images,
the integration of both local and global networks learn more complete and
specific features for DR analysis. (2) By introducing imbalanced weighting map,
more attentions will be given to lesion patches for DR grading, which
significantly improve the performance of the proposed algorithm. In this study,
we label 12,206 lesion patches and re-annotate the DR grades of 23,595 fundus
images from Kaggle competition dataset. Under the guidance of clinical
ophthalmologists, the experimental results show that our local lesion detection
net achieve comparable performance with trained human observers, and the
proposed imbalanced weighted scheme also be proved to significantly improve the
capability of our DCNN-based DR grading algorithm
Faculty Excellence
Each year, the University of New Hampshire selects a small number of its outstanding faculty for special recognition of their achievements in teaching, scholarship and service. Awards for Excellence in Teaching are given in each college and school, and university-wide awards recognize public service, research, teaching and engagement. This booklet details the year\u27s award winners\u27 accomplishments in short profiles with photographs and text
Proceedings of Abstracts Engineering and Computer Science Research Conference 2019
© 2019 The Author(s). This is an open-access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For further details please see https://creativecommons.org/licenses/by/4.0/. Note: Keynote: Fluorescence visualisation to evaluate effectiveness of personal protective equipment for infection control is © 2019 Crown copyright and so is licensed under the Open Government Licence v3.0. Under this licence users are permitted to copy, publish, distribute and transmit the Information; adapt the Information; exploit the Information commercially and non-commercially for example, by combining it with other Information, or by including it in your own product or application. Where you do any of the above you must acknowledge the source of the Information in your product or application by including or linking to any attribution statement specified by the Information Provider(s) and, where possible, provide a link to this licence: http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/This book is the record of abstracts submitted and accepted for presentation at the Inaugural Engineering and Computer Science Research Conference held 17th April 2019 at the University of Hertfordshire, Hatfield, UK. This conference is a local event aiming at bringing together the research students, staff and eminent external guests to celebrate Engineering and Computer Science Research at the University of Hertfordshire. The ECS Research Conference aims to showcase the broad landscape of research taking place in the School of Engineering and Computer Science. The 2019 conference was articulated around three topical cross-disciplinary themes: Make and Preserve the Future; Connect the People and Cities; and Protect and Care
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