193,316 research outputs found

    System reliability analyses and optimal maintenance planning of corroding pipelines

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    The failure of corroding pipeline joints may induce severe consequences. However, maintenance is expensive due to the cost of excavating and repairing a single joint and typically a significant number of joints that need repair. It is central to develop an optimal cost-effective maintenance strategy that balances cost and safety. A key component of the strategy is the reliability based condition evaluation of pipeline joints. The focus of the research reported in this thesis is therefore developing efficient reliability assessment methods for pipeline individual joints, and developing an optimal maintenance framework for the entire pipeline system. First, efficient system reliability methods relying on the first-order reliability method (FORM) and important sampling (IS) are developed for the assessment of the time-dependent probabilities of small leak and burst failure of pipeline joints containing multiple corrosion defects. In addition, a novel method is developed within the FORM to obtain the design points efficiently. An improved equivalent component approach for evaluating multi-normal integrals is also developed to improve the efficiency of the FORM for system reliability analysis. In addition, a multi-objective optimization-based maintenance framework for corroding pipeline systems is formulated optimizing three objectives, i.e. the conditioned probabilities of burst and small leak, respectively, and repair cost. An improved genetic algorithm with a pre-training population is utilized to investigate the optimal Pareto front. The benefits of this framework enable decision makers to access a series of non-dominated optimal repairing solutions with respect to multiple conflicting objectives

    Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres

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    Recent studies implicate a number of DNA repair proteins in mammalian telomere maintenance. However, because several key repair proteins in mammals are missing from the well-studied budding and fission yeast, their roles at telomeres cannot be modeled in standard fungi. In this report, we explored the dimorphic fungus Ustilago maydis as an alternative model for telomere research. This fungus, which belongs to the phylum Basidiomycota, has a telomere repeat unit that is identical to the mammalian repeat, as well as a constellation of DNA repair proteins that more closely mimic the mammalian collection. We showed that the two core components of homology-directed repair (HDR) in U. maydis, namely Brh2 and Rad51, both promote telomere maintenance in telomerase positive cells, just like in mammals. In addition, we found that Brh2 is localized to telomeres in vivo, suggesting that it acts directly at chromosome ends. We surveyed a series of mutants with DNA repair defects, and found many of them to have short telomeres. Our results indicate that factors involved in DNA repair are probably also needed for optimal telomere maintenance in U. maydis, and that this fungus is a useful alternative model system for telomere research.This is the peer reviewed version of the paper: Yu, E. Y., Kojic, M., Holloman, W. K., & Lue, N. F. (2013). Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres. DNA Repair, 12(7), 472–479.[ https://doi.org/10.1016/j.dnarep.2013.04.027]Published version: [https://imagine.imgge.bg.ac.rs/handle/123456789/653

    Selective maintenance optimisation for series-parallel systems alternating missions and scheduled breaks with stochastic durations

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    This paper deals with the selective maintenance problem for a multi-component system performing consecutive missions separated by scheduled breaks. To increase the probability of successfully completing its next mission, the system components are maintained during the break. A list of potential imperfect maintenance actions on each component, ranging from minimal repair to replacement is available. The general hybrid hazard rate approach is used to model the reliability improvement of the system components. Durations of the maintenance actions, the mission and the breaks are stochastic with known probability distributions. The resulting optimisation problem is modelled as a non-linear stochastic programme. Its objective is to determine a cost-optimal subset of maintenance actions to be performed on the components given the limited stochastic duration of the break and the minimum system reliability level required to complete the next mission. The fundamental concepts and relevant parameters of this decision-making problem are developed and discussed. Numerical experiments are provided to demonstrate the added value of solving this selective maintenance problem as a stochastic optimisation programme

    Operational strategies for offshore wind turbines to mitigate failure rate uncertainty on operational costs and revenue

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    Several operational strategies for offshore wind farms have been established and explored in order to improve understanding of operational costs with a focus on heavy lift vessel strategies. Additionally, an investigation into the uncertainty surrounding failure behaviour has been performed identifying the robustness of different strategies. Four operational strategies were considered: fix on fail, batch repair, annual charter and purchase. A range of failure rates have been explored identifying the key cost drivers and under which circumstances an operator would choose to adopt them. When failures are low, the fix on fail and batch strategies perform best and allow flexibility of operating strategy. When failures are high, purchase becomes optimal and is least sensitive to increasing failure rate. Late life failure distributions based on mechanical and electrical components behaviour have been explored. Increased operating costs because of wear-out failures have been quantified. An increase in minor failures principally increase lost revenue costs and can be mitigated by deploying increased maintenance resources. An increase in larger failures primarily increases vessel and repair costs. Adopting a purchase strategy can negate the vessel cost increase; however, significant cost increases are still observed. Maintenance actions requiring the use of heavy lift vessels, currently drive train components and blades are identified as critical for proactive maintenance to minimise overall maintenance costs

    The effect of temperature on bacterial self-healing processes in building materials

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    This paper is focused on the bacterial induced calcitation for the crack healing. The bacteria applied for this purpose are from group which is adapted for growth in the high pH environment as a concrete in hydration phase and their metabolic activity leads to create of calcite. In this study, three different bacteria strains (Sporosarcina pasteurii, Bacillus cohnii, Bacillus pseudofirmus) were applied and the influence of various temperatures on their microbial properties was investigated. Our previous experiment indicated that one of the applied bacterial strain in spores form (Bacillus pseudofirmus) are able to survive the temperatures in the range from −20 °C to 140 °C. The xperiment described in this paper extends the previous study and determines the effect of different temperatures on the change in growth activity. In this experiment, bacterial activity was determined based on the change of absorbance in 640 nm by spectrophotometric measurements. The experiment was performed at optimal temperature (30 °C) and lower temperature (10 °C) and it used suitable broth for calcitation. The results showed that the beginning of metabolic activity was shifted by 40 to 50 hours. Only Bacillus cohnii showed different results because its metabolic activity was nearly zero at 10 °C
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