Applying Genetic Algorithm to Generation of High-Dimensional Item Response Data

The item response data is the nm-dimensional data based on the responses made by m examinees to the questionnaire consisting of n items. It is used to estimate the ability of examinees and item parameters in educational evaluation. For estimates to be valid, the simulation input data must reflect reality. This paper presents the effective combination of the genetic algorithm (GA) and Monte Carlo methods for the generation of item response data as simulation input data similar to real data. To this end, we generated four types of item response data using Monte Carlo and the GA and evaluated how similarly the generated item response data represents the real item response data with the item parameters (item difficulty and discrimination). We adopt two types of measurement, which are root mean square error and Kullback-Leibler divergence, for comparison of item parameters between real data and four types of generated data. The results show that applying the GA to initial population generated by Monte Carlo is the most effective in generating item response data that is most similar to real item response data. This study is meaningful in that we found that the GA contributes to the generation of more realistic simulation input data

L-Music: uma abordagem para composição musical assistida usando L-Systems

Generative music systems have been researched for an extended period of time. The scientific corpus of this research field is translating, currently, into the world of the everyday musician and composer. With these tools, the creative process of writing music can be augmented or completely replaced by machines. The work in this document aims to contribute to research in assisted music composition systems. To do so, a review on the state of the art of these fields was performed and we found that a plethora of methodologies and approaches each provide their own interesting results (to name a few, neural networks, statistical models, and formal grammars). We identified Lindenmayer Systems, or L-Systems, as the most interesting and least explored approach to develop an assisted music composition system prototype, aptly named L-Music, due to the ability of producing complex outputs from simple structures. L-Systems were initially proposed as a parallel string rewriting grammar to model algae plant growth. Their applications soon turned graphical (e.g., drawing fractals), and eventually they were applied to music generation. Given that our prototype is assistive, we also took the user interface and user experience design into its well-deserved consideration. Our implemented interface is straightforward, simple to use with a structured visual hierarchy and flow and enables musicians and composers to select their desired instruments; select L-Systems for generating music or create their own custom ones and edit musical parameters (e.g., scale and octave range) to further control the outcome of L-Music, which is musical fragments that a musician or composer can then use in their own works. Three musical interpretations on L-Systems were implemented: a random interpretation, a scale-based interpretation, and a polyphonic interpretation. All three approaches produced interesting musical ideas, which we found to be potentially usable by musicians and composers in their own creative works. Although positive results were obtained, the developed prototype has many improvements for future work. Further musical interpretations can be added, as well as increasing the number of possible musical parameters that a user can edit. We also identified the possibility of giving the user control over what musical meaning L-Systems have as an interesting future challenge.Sistemas de geração de música têm sido alvo de investigação durante períodos alargados de tempo. Recentemente, tem havido esforços em passar o conhecimento adquirido de sistemas de geração de música autónomos e assistidos para as mãos do músico e compositor. Com estas ferramentas, o processo criativo pode ser enaltecido ou completamente substituído por máquinas. O presente trabalho visa contribuir para a investigação de sistemas de composição musical assistida. Para tal, foi efetuado um estudo do estado da arte destas temáticas, sendo que foram encontradas diversas metodologias que ofereciam resultados interessantes de um ponto de vista técnico e musical. Os sistemas de Lindenmayer, ou L-Systems, foram selecionados como a abordagem mais interessante, e menos explorada, para desenvolver um protótipo de um sistema de composição musical assistido com o nome L-Music, devido à sua capacidade de produzirem resultados complexos a partir de estruturas simples. Os L-Systems, inicialmente propostos para modelar o crescimento de plantas de algas, são gramáticas formais, cujo processo de reescrita de strings acontece de forma paralela. As suas aplicações rapidamente evoluíram para interpretações gráficas (p.e., desenhar fractais), e eventualmente também foram aplicados à geração de música. Dada a natureza assistida do protótipo desenvolvido, houve uma especial atenção dada ao design da interface e experiência do utilizador. Esta, é concisa e simples, tendo uma hierarquia visual estruturada para oferecer uma orientação coesa ao utilizador. Neste protótipo, os utilizadores podem selecionar instrumentos; selecionar L-Systems ou criar os seus próprios, e editar parâmetros musicais (p.e., escala e intervalo de oitavas) de forma a gerarem excertos musicais que possam usar nas suas próprias composições. Foram implementadas três interpretações musicais de L-Systems: uma interpretação aleatória, uma interpretação à base de escalas e uma interpretação polifónica. Todas as interpretações produziram resultados musicais interessantes, e provaram ter potencial para serem utilizadas por músicos e compositores nos seus trabalhos criativos. Embora tenham sido alcançados resultados positivos, o protótipo desenvolvido apresenta múltiplas melhorias para trabalho futuro. Entre elas estão, por exemplo, a adição de mais interpretações musicais e a adição de mais parâmetros musicais editáveis pelo utilizador. A possibilidade de um utilizador controlar o significado musical de um L-System também foi identificada como uma proposta futura relevante

INDUCTION OF TOLERANCE BY ORAL ADMINISTRATION OF FACTOR VIII AND TREATMENT OF HEMOPHILA

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a Subject a therapeutically effective amount of the deficient anti gen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac atherapeutically effective amount of the appropriate clotting factor other than in a liposome, Sufficient to induce oral tolerance and Supply exogenous clotting factor to the subject

Method and System for Identification of Metabolites Using Mass Spectra

A method and system is provided for mass spectrometry for identification of a specific elemental formula for an unknown compound which includes but is not limited to a metabolite. The method includes calculating a natural abundance probability (NAP) of a given isotopologue for isotopes of non-labelling elements of an unknown compound. Molecular fragments for a subset of isotopes identified using the NAP are created and sorted into a requisite cache data structure to be subsequently searched. Peaks from raw spectrum data from mass spectrometry for an unknown compound. Sample-specific peaks of the unknown com- pound from various spectral artifacts in ultra-high resolution Fourier transform mass spectra are separated. A set of possible isotope-resolved molecular formula (IMF) are created by iteratively searching the molecular fragment caches and combining with additional isotopes and then statistically filtering the results based on NAP and mass-to-charge (m/2) matching probabilities. An unknown compound is identified and its corresponding elemental molecular formula (EMF) from statistically-significant caches of isotopologues with compatible IMFs

Simple identification tools in FishBase

Simple identification tools for fish species were included in the FishBase information system from its inception. Early tools made use of the relational model and characters like fin ray meristics. Soon pictures and drawings were added as a further help, similar to a field guide. Later came the computerization of existing dichotomous keys, again in combination with pictures and other information, and the ability to restrict possible species by country, area, or taxonomic group. Today, www.FishBase.org offers four different ways to identify species. This paper describes these tools with their advantages and disadvantages, and suggests various options for further development. It explores the possibility of a holistic and integrated computeraided strategy

ORAL TREATMENT OF HEMOPHILIA

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject

The development and evaluation of an experiential computer simulation for animal science students

After reviewing the literature regarding the use of computers in education, the researcher identified a gap between state-of-art educational research and current educational practice; the majority of the presently available CAL software lacked appropriate design features that would enable the computer to meet its potential for the infusion of problem solving, information processing, and model building skills into the existing curriculum. With this gap in mind, the researcher proposed the development of a CAL lesson that could serve as a model of one type of computer use that better met the need for infusion of higher order thinking skills into the curriculum and also to serve as a model of how to develop software with these goals in mind;An experiential computer simulation was designed, using a state-of-the-art software development system, to enhance teaching and learning of a limited concept in animal science. A field test was undertaken with animal science students in order to determine lesson revisions needed to ensure the lesson adequately interacted with the varying student models. Results indicated that this lesson could enhance the existing curriculum, and that much attention throughout the developmental process must be focused on the possible student models and how the lesson can provide appropriate feedback for each student