2,098 research outputs found
A Comparison of Spatial-based Targeted Disease Containment Strategies using Mobile Phone Data
Epidemic outbreaks are an important healthcare challenge, especially in
developing countries where they represent one of the major causes of mortality.
Approaches that can rapidly target subpopulations for surveillance and control
are critical for enhancing containment processes during epidemics.
Using a real-world dataset from Ivory Coast, this work presents an attempt to
unveil the socio-geographical heterogeneity of disease transmission dynamics.
By employing a spatially explicit meta-population epidemic model derived from
mobile phone Call Detail Records (CDRs), we investigate how the differences in
mobility patterns may affect the course of a realistic infectious disease
outbreak. We consider different existing measures of the spatial dimension of
human mobility and interactions, and we analyse their relevance in identifying
the highest risk sub-population of individuals, as the best candidates for
isolation countermeasures. The approaches presented in this paper provide
further evidence that mobile phone data can be effectively exploited to
facilitate our understanding of individuals' spatial behaviour and its
relationship with the risk of infectious diseases' contagion. In particular, we
show that CDRs-based indicators of individuals' spatial activities and
interactions hold promise for gaining insight of contagion heterogeneity and
thus for developing containment strategies to support decision-making during
country-level pandemics
Analyzing the Spread of Chagas Disease with Mobile Phone Data
We use mobile phone records for the analysis of mobility patterns and the
detection of possible risk zones of Chagas disease in two Latin American
countries. We show that geolocalized call records are rich in social and
individual information, which can be used to infer whether an individual has
lived in an endemic area. We present two case studies, in Argentina and in
Mexico, using data provided by mobile phone companies from each country. The
risk maps that we generate can be used by health campaign managers to target
specific areas and allocate resources more effectively.Comment: 6 pages, 6 figure
On the use of human mobility proxy for the modeling of epidemics
Human mobility is a key component of large-scale spatial-transmission models
of infectious diseases. Correctly modeling and quantifying human mobility is
critical for improving epidemic control policies, but may be hindered by
incomplete data in some regions of the world. Here we explore the opportunity
of using proxy data or models for individual mobility to describe commuting
movements and predict the diffusion of infectious disease. We consider three
European countries and the corresponding commuting networks at different
resolution scales obtained from official census surveys, from proxy data for
human mobility extracted from mobile phone call records, and from the radiation
model calibrated with census data. Metapopulation models defined on the three
countries and integrating the different mobility layers are compared in terms
of epidemic observables. We show that commuting networks from mobile phone data
well capture the empirical commuting patterns, accounting for more than 87% of
the total fluxes. The distributions of commuting fluxes per link from both
sources of data - mobile phones and census - are similar and highly correlated,
however a systematic overestimation of commuting traffic in the mobile phone
data is observed. This leads to epidemics that spread faster than on census
commuting networks, however preserving the order of infection of newly infected
locations. Match in the epidemic invasion pattern is sensitive to initial
conditions: the radiation model shows higher accuracy with respect to mobile
phone data when the seed is central in the network, while the mobile phone
proxy performs better for epidemics seeded in peripheral locations. Results
suggest that different proxies can be used to approximate commuting patterns
across different resolution scales in spatial epidemic simulations, in light of
the desired accuracy in the epidemic outcome under study.Comment: Accepted fro publication in PLOS Computational Biology. Abstract
shortened to fit Arxiv limits. 35 pages, 6 figure
Stochasticity in pandemic spread over the World Airline Network explained by local flight connections
Massive growth in human mobility has dramatically increased the risk and rate
of pandemic spread. Macro-level descriptors of the topology of the World
Airline Network (WAN) explains middle and late stage dynamics of pandemic
spread mediated by this network, but necessarily regard early stage variation
as stochastic. We propose that much of early stage variation can be explained
by appropriately characterizing the local topology surrounding the debut
location of an outbreak. We measure for each airport the expected force of
infection (AEF) which a pandemic originating at that airport would generate. We
observe, for a subset of world airports, the minimum transmission rate at which
a disease becomes pandemically competent at each airport. We also observe, for
a larger subset, the time until a pandemically competent outbreak achieves
pandemic status given its debut location. Observations are generated using a
highly sophisticated metapopulation reaction-diffusion simulator under a
disease model known to well replicate the 2009 influenza pandemic. The
robustness of the AEF measure to model misspecification is examined by
degrading the network model. AEF powerfully explains pandemic risk, showing
correlation of 0.90 to the transmission level needed to give a disease pandemic
competence, and correlation of 0.85 to the delay until an outbreak becomes a
pandemic. The AEF is robust to model misspecification. For 97% of airports,
removing 15% of airports from the model changes their AEF metric by less than
1%. Appropriately summarizing the size, shape, and diversity of an airport's
local neighborhood in the WAN accurately explains much of the macro-level
stochasticity in pandemic outcomes.Comment: article text: 6 pages, 5 figures, 28 reference
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