1,910 research outputs found
Mobile Glaucoma Detection Application
Glaucoma is a debilitating optical degeneration disease that can lead to vision loss and eventually blindness. Given its asymptomatic nature, most people with Glaucoma arenât even aware that they have the disease. As a result, the disease is often left untreated until it is too late. Detecting the presence of Glaucoma is one of the most important steps in treating Glaucoma, but is unfortunately also the most difficult to enforce. The Mobile Glaucoma Detection application aims to reduce the growing number of individuals who are unaware that they have Glaucoma by providing a simple detection mechanism to notify users if they are at risk. The system does this by enabling its users to independently conduct Tonometry exams through the application. Tonometry examinations allow doctors to determine if the intra-ocular pressure levels in a personâs eyes put them at risk for Glaucoma. The M.G.D.A(Mobile Glaucoma Detection Application) allows users to determine their intra-ocular pressure levels from the comfort of their own home via a special contact lens paired with a smartphone application. The system also offers users the opportunity to monitor, regulate, and track their use and progress through the system
The mPower Study, Parkinson Disease Mobile Data Collected Using Researchkit
Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide meaningful feedback to individuals. The impact of high-resolution activity data collected from mobile phones is only beginning to be explored. Here we present data from mPower, a clinical observational study about Parkinson disease conducted purely through an iPhone app interface. The study interrogated aspects of this movement disorder through surveys and frequent sensor-based recordings from participants with and without Parkinson disease. Benefitting from large enrollment and repeated measurements on many individuals, these data may help establish baseline variability of real-world activity measurement collected via mobile phones, and ultimately may lead to quantification of the ebbs-and-flows of Parkinson symptoms. App source code for these data collection modules are available through an open source license for use in studies of other conditions. We hope that releasing data contributed by engaged research participants will seed a new community of analysts working collaboratively on understanding mobile health data to advance human health
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Development and evaluation of point-of-care diagnostic technologies for providers and consumers
Point-of-care (POC) diagnostic technologies aim to expand access to traditional laboratory-based testing to near-patient settings. These settings can range from emergency or intensive care-units (ICUs) in the United States, to remote health posts in sub Saharan Africa. Differences in budget and infrastructure play a role in characterizing the wide array of possible ânear patientâ settings and must be taken into consideration in the engineering design process. In this dissertation we use translational engineering to develop practical and accessible microfluidic POC immunoassays for diverse settings, that include both provider and consumer facing applications.
First, we examined Lyme Disease in the U.S., where existing diagnostic technologies face the challenge of rapid and accurate serodiagnosis in the face of largely non-specific clinical symptoms. We developed a multiplexed rapid test that could replicate enzyme-linked immunosorbent assay (ELISA) performance for Lyme Disease diagnosis. After screening candidate biomarkers, we evaluated performance of the multiplexed microfluidic test against ELISA using clinical serum samples and illustrated the potential to streamline current clinical algorithms requiring two immunoassays (ELISA and Western Blot) into one standalone test suitable for physicianâs offices or urgent care clinics in the U.S. We also showed exploratory work towards a similar multiplexed test design for another bacterial spirochete infection, Leptospirosis.
Next, we built on previous work towards a POC HIV-syphilis antenatal screening tool, to develop a smartphone-integrated, microfluidic assay for healthcare workers to use in low resource settings. The low-cost (34 to produce and provides results in 15 minutes. In this work, we focus on assay development efforts undertaken towards development of a fully integrated POC product suitable for deployment in the field, with practical considerations for the use of fingerstick blood, stability, scale-up and transport. We also streamlined the number of manual steps for end-user operation, through the use of lyophilized secondary antibodies, preloaded reagents on cassette, and an automatic result readout. While laboratory demonstration with clinical samples is important for initial characterization of POC devices, field evaluation reveals diagnostic performance under real-world conditions. We tested the device in the hands of minimally trained healthcare workers in Rwanda and saw comparable performance to other immunoassays run under field conditions. We also performed a follow-up pilot field study in Rwanda to evaluate the feasibility of the smartphone dongle platform for self-testing by patients/consumers in a low-resource setting, one of the most challenging use-cases for POC devices.
Finally, we sought to integrate intellectual frameworks from behavioral research and user-experience (UX) design in creating a new framework for evaluation of consumer-facing microfluidic devices, specifically towards HIV home-testing in the U.S. While overall rates of HIV are decreasing in the U.S., the population of gay, bisexual and other men who have sex with men (MSM) are disproportionately affected. Self-testing products for sexually transmitted infection (STI) testing could address unmet needs for these target populations in both increasing access and frequency of testing, as well as integrating use with sexual partners for early diagnosis or even prevention. We worked with a cohort of MSMs at high risk for HIV/STI transmission in New York City, and performed for the first time, a structured assessment of completely naĂŻve users interacting with a smartphone interfaced microfluidic diagnostic device (âSMARTtestâ). We integrated UX design value model of device usability, credibility, accessibility and acceptability into our evaluation framework, which influence userâs information, knowledge, motivation and behavioral skills towards engaging with a prevention method (âIMBâ model). Thus far, such frameworks have rarely been applied to other consumer health monitoring devices, including microfluidic POC devices. As the microfluidic field moves towards more field demonstrations of devices, more untrained and minimally trained users will have access to such tools. It is important to understand how they use devices, what the device failure points are and what the most relevant design features are to spur user adoption and meaningful usage.
Underlying our work in creating accessible and practical POC immunoassay tools for infectious disease detection, is the illustration of the translational development roadmap from proof-of-concept assay development to field studies and user-based evaluations for intended end-use settings that range from U.S. based primary care clinics, rural health centers in low-resource settings as well as self-testing environments in both. Incorporating an understanding of the target use-case setting is critical in translating technologies for clinical use, whether in the infrastructure and services that are available, or end-user needs and constraints such as clinical workflow patterns, level of technical expertise and perceptions of usefulness and value. We show how user/use-case focused application of downstream translational engineering and testing informs upstream design choices and accelerates development of POC devices for real-world use. The sum of this work aims to illustrate tenets of translational engineering design and testing to advance insight into building POC products that are poised for greater adoption by target end users, whether they are health providers or consumers
The impact of a digital wheeze detector on parental disease management of pre-school children suffering from wheezingâa pilot study
Background: Viral airway infections are a major reason for doctor's visits at pre-school age, especially when associated with wheezing. While proper treatment requires adequate recognition of airway obstruction, caretakers are often struggling with this judgment, consequently leading to insufficient or late treatment and an unnecessary discomfort of the patient. Digital technologies may serve to support parental decision taking. The aim of the present pilot study is to acquire data on the feasibility of recruitment and observation procedures for a randomized controlled trial on the impact of a digital wheeze detector in a home management setting of pre-school wheezing.
Methods: This single-armed pilot study enrolled patients with a doctor's diagnosis of wheezing aged 9 to 72 months. Participants were asked to use a digital wheeze detector (WheezeScan, Omron Healthcare, Japan) 2x/day for 30 days and record the child's respiratory symptoms, detection of wheezing, and medication intake via an electronic diary (eDiary) app. Demographic and clinical data were collected at the recruitment visit. The asthma control test and the Parent Asthma Management Self-Efficacy Scale (PAMSES) were assessed both, at recruitment and follow-up.
Results: Twenty families were recruited and completed the monitoring. All but one completed the follow-up after 30 days. The recruitment procedures were feasible, and adherence to daily monitoring reached an average of 81%. The use of the wheeze detector was rated as uncomplicated. Parents detected wheezing without digital support in only 22/708 (3.1%) of the recorded events. By contrast, the wheeze detector indicated an airway obstruction in 140/708 (19.8%) of the recordings.
Conclusion: In parallel to feasible recruitment procedures, we observed good usability of the wheeze detection device and high adherence to eDiary recording. The positive outcomes show that the WheezeScan may empower parents by increasing their capacity for wheeze detection. This deserves to be investigated in a larger randomized controlled trial
Mobile Crowd Sensing Services for Tinnitus Assessment, Therapy and Research
Tinnitus, the phantom sensation of sound, is a highly prevalent disorder that is difficult to treat; i.e., available treatments are only effective for patient subgroups. Sufficiently large and qualitative longitudinal data sets, which aggregate the individualsâ demographic and clinical characteristics, together with their response to specific therapeutic interventions, would therefore facilitate evidence-based treatment suggestions for individual patients. Currently, clinical trials are the standard instrument for realizing evidence-based medicine. However, the related information gathering is limited. For example, clinical trials try to reduce the complexity of the individual case by generating homogeneous groups to obtain significant results. From the latter, individual treatment decisions are inferred. A complementary approach would be to assess the effect of specific interventions in large samples considering the individual peculiarity of each subject. This allows providing individualized treatment decisions. Recently, mobile crowd sensing emerged as an approach for collecting large and ecological valid datasets at rather low costs. By providing mobile crowd sensing services to large numbers of patients, large datasets can be gathered cheaply on a daily basis. In the TrackYourTinnitus project, we implemented a mobile crowd sensing platform to reveal new medical aspects on tinnitus and its treatment. Additionally, we work on mobile services exploring approaches for understanding tinnitus and for improving its diagnostic and therapeutic management. We present the TrackYourTinnitus platform as well as its goals, architecture and preliminary results. Overall, the platform and its mobile services offer promising perspectives for tinnitus research and treatment
The far side of mobile application integrated development environments
Š Springer International Publishing Switzerland 2016. Smart phones are, nowadays, a necessity for the vast majority of individuals around the globe. In addition to the ubiquitous computing paradigm supported by such devices, there are numerous software applications that utilize the high computational capabilities that they offer. This type of software is a vital part of what is known as e-Commerce, with a variety of business models proposed and implemented. Lately, a new era of free-ware mobile application has arisen with paid features and promoted content in them. Piracy is not only the weakest point of softwareâs financial ecosystem for conventional computing systems but also for smartphones. Actions like replication, redistribution and licensing violations can cause financial losses of colossal extent to their creators. Mobile applications also introduce the following peculiarity: They are distributed through predefined channels (Application Stores) owned by mobile operating system vendors such as Apple, Google and Microsoft. In this research we present several scenarios where cracked and modified applications can be freely used into every non jailbroken iOS device. Moreover it is demonstrated that not even in strict mobile environments, such as Appleâs, end-users should be considered as trusted entities from application developers by default
iPad use in stroke neuro-rehabilitation
Neuro-rehabilitation services are essential in reducing post-stroke impairments, enhancing independence, and improving recovery in hospital and post-discharge. However these services are therapist-dependent and resource intensive. Patientsâ disengagement and boredom in stroke units are common which adversely affect functional and psychological outcomes. Novel techniques such as use of iPads⢠are increasingly researched to overcome such challenges. The aim of this review is to determine the feasibility, effectiveness, acceptability, and barriers to the use of iPads⢠in stroke neuro-rehabilitation. Four databases and manual literature search were used to identify published studies using the terms âiPadâ, âStrokeâ, and âneuro-rehabilitationâ. Studies were included in accordance with the review selection criteria. A total of 16 articles were included in the review. The majority of the studies focused on iPads use in speech and language therapy. Although of small scale, the studies highlighted that iPads are feasible, have the potential to improve rehabilitation outcomes, and can improve patientâs social isolation. Patientsâ stroke severity and financial limitations are some of the barriers highlighted in this review. This review presents preliminary data supportive for the use of iPad technology in stroke neuro-rehabilitation. However, further research is needed to determine impact on rehabilitation goals acquisition, clinical efficacy, and cost-efficiency
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