Connectivity analysis with structural equation modelling: an example of the effects of voxel selection

Structural equation modelling (SEM) of neuroimaging data is commonly applied to a network of distributed brain regions. We applied SEM to an fMRI dataset to identify condition-specific effects in a simple experiment composed of visual stimulation and baseline conditions. The visual network was composed of three well-defined anatomical regions (V1, V2, and V5) and three path connections (V1 → V2, V1 → V5, and V2 → V5). This network was used to test four hypotheses: (1) whether the condition-specific effects for all three connections vary according to the data selected for modelling; (2) whether the “summary” measures that are often used are indeed appropriate; (3) whether measures taken from the voxel timecourse can reliably predict the condition-specific effects for each one of the three path connections, and (4) whether all voxels within an anatomical region yield equivalent SEM outcomes. There was some variability in the significance of the condition-specific effects across randomly selected voxels within regions. However, the SEM outcome from the “summary” measures was comparable to the most frequent pattern of condition-specific effects. Magnitude, delay, spread, and goodness-of-fit measures taken from a gamma fit to the voxel time courses predicted reliably the significance of the SEM condition-specific effects for each connection. This result enabled us to identify spatially coherent regions at the boundaries of V2 that displayed different condition-specific effects from those seen in the majority of the voxels. Although the generality of these results awaits further investigation, this example highlights a number of important issues for SEM

Optimizing construction of scheduled data flow graph for on-line testability

The objective of this work is to develop a new methodology for behavioural synthesis using a flow of synthesis, better suited to the scheduling of independent calculations and non-concurrent online testing. The traditional behavioural synthesis process can be defined as the compilation of an algorithmic specification into an architecture composed of a data path and a controller. This stream of synthesis generally involves scheduling, resource allocation, generation of the data path and controller synthesis. Experiments showed that optimization started at the high level synthesis improves the performance of the result, yet the current tools do not offer synthesis optimizations that from the RTL level. This justifies the development of an optimization methodology which takes effect from the behavioural specification and accompanying the synthesis process in its various stages. In this paper we propose the use of algebraic properties (commutativity, associativity and distributivity) to transform readable mathematical formulas of algorithmic specifications into mathematical formulas evaluated efficiently. This will effectively reduce the execution time of scheduling calculations and increase the possibilities of testability

Analysis of Ultrafast Transient Absorption Spectroscopy Data using Integrative Data Analysis Platform: 1. Data Processing, Fitting, and Model Selection

This manuscript describes a workflow for analysis of transient absorption (TA) spectroscopy data using Integrative Data Analysis Platforms (IDAP) software package. Time-dependent spectral series are analyzed through evaluation of the isosbestic point and kinetics of excited state and ground-state bleach decays. Model fitting and selection based on Akaike\u27s Information Criterion is discussed. As a practical example, we analyze excitation decays of a common protein label, Alexa Fluor 647

Assessment of flying-quality criteria for air-breathing aerospacecraft

A study of flying quality requirements for air breathing aerospacecraft gives special emphasis to the unusual operational requirements and characteristics of these aircraft, including operation at hypersonic speed. The report considers distinguishing characteristics of these vehicles, including dynamic deficiencies and their implications for control. Particular emphasis is given to the interaction of the airframe and propulsion system, and the requirements for dynamic systems integration. Past operational missions are reviewed to define tasks and maneuvers to be considered for this class of aircraft. Areas of special concern with respect to vehicle dynamics and control are identified. Experience with the space shuttle orbiter is reviewed with respect to flight control system mechanization and flight experience in approach and landing flying qualities for the National Aerospace Plane (NASP)

Experimental L-band SST satellite communications/surveillance terminal study. Volume 1 - Study summary

Study of design for experimental L band supersonic transport communications/surveillance termina

Analysis and hardware testing of cell capacitor discharge currents during DC faults in half-bridge modular multilevel converters

This paper focuses on the behaviour of the cell capacitor discharge currents during DC faults in half-bridge modular multilevel converters. Active switches, not designed for fault conditions, are tripped to minimize discharge currents effect on the semiconductor switches. Two levels of device protection are commonly in place; driver level protection monitoring collector-emitter voltage and overcurrent protection with feedback measurement and control. However, unavoidable tripping delay times, arising from factors such as sensor lags, controller sampling delays and hardware propagation delays, impact transient current shape and hence affect the selection of semiconductor device ratings as well as arm inductance. Analytical expressions are obtained for current slew rate, peak transient current and resultant I2t for the cell capacitor discharge current taking into account such delays. The study is backed by experimental testing on discharge of a 900V MMC capacitor