Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization

Structural heterogeneity constitutes one of the main substrates influencing impulse propagation in living tissues. In cardiac muscle, improved understanding on its role is key to advancing our interpretation of cell-to-cell coupling, and how tissue structure modulates electrical propagation and arrhythmogenesis in the intact and diseased heart. We propose fractional diffusion models as a novel mathematical description of structurally heterogeneous excitable media, as a mean of representing the modulation of the total electric field by the secondary electrical sources associated with tissue inhomogeneities. Our results, validated against in-vivo human recordings and experimental data of different animal species, indicate that structural heterogeneity underlies many relevant characteristics of cardiac propagation, including the shortening of action potential duration along the activation pathway, and the progressive modulation by premature beats of spatial patterns of dispersion of repolarization. The proposed approach may also have important implications in other research fields involving excitable complex media

Systems control theory applied to natural and synthetic musical sounds

Systems control theory is a far developped field which helps to study stability, estimation and control of dynamical systems. The physical behaviour of musical instruments, once described by dynamical systems, can then be controlled and numerically simulated for many purposes. The aim of this paper is twofold: first, to provide the theoretical background on linear system theory, both in continuous and discrete time, mainly in the case of a finite number of degrees of freedom ; second, to give illustrative examples on wind instruments, such as the vocal tract represented as a waveguide, and a sliding flute

Mathematical and Numerical Aspects of Dynamical System Analysis

From Preface: This is the fourteenth time when the conference “Dynamical Systems: Theory and Applications” gathers a numerous group of outstanding scientists and engineers, who deal with widely understood problems of theoretical and applied dynamics. Organization of the conference would not have been possible without a great effort of the staff of the Department of Automation, Biomechanics and Mechatronics. The patronage over the conference has been taken by the Committee of Mechanics of the Polish Academy of Sciences and Ministry of Science and Higher Education of Poland. It is a great pleasure that our invitation has been accepted by recording in the history of our conference number of people, including good colleagues and friends as well as a large group of researchers and scientists, who decided to participate in the conference for the first time. With proud and satisfaction we welcomed over 180 persons from 31 countries all over the world. They decided to share the results of their research and many years experiences in a discipline of dynamical systems by submitting many very interesting papers. This year, the DSTA Conference Proceedings were split into three volumes entitled “Dynamical Systems” with respective subtitles: Vibration, Control and Stability of Dynamical Systems; Mathematical and Numerical Aspects of Dynamical System Analysis and Engineering Dynamics and Life Sciences. Additionally, there will be also published two volumes of Springer Proceedings in Mathematics and Statistics entitled “Dynamical Systems in Theoretical Perspective” and “Dynamical Systems in Applications”

Fractional dynamical model for the generation of ECG like signals from filtered coupled Van-der Pol oscillators

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.In this paper, an incommensurate fractional order (FO) model has been proposed to generate ECG like waveforms. Earlier investigation of ECG like waveform generation is based on two identical Van-der Pol (VdP) family of oscillators, which are coupled by time delays and gains. In this paper, we suitably modify the three state equations corresponding to the nonlinear cross-product of states, time delay coupling of the two oscillators and low-pass filtering, using the concept of fractional derivatives. Our results show that a wide variety of ECG like waveforms can be simulated from the proposed generalized models, characterizing heart conditions under different physiological conditions. Such generalization of the modelling of ECG waveforms may be useful to understand the physiological process behind ECG signal generation in normal and abnormal heart conditions. Along with the proposed FO models, an optimization based approach is also presented to estimate the VdP oscillator parameters for representing a realistic ECG like signal.The work presented in this paper was supported by the E.U. ARTEMIS Joint Undertaking under the Cyclic and Person-Centric Health Management: Integrated appRoach for hOme, mobile and clinical eNvironments – (CHIRON) Project, Grant Agreement # 2009-1-100228

Fractional Group Iterative Methods For Two Dimensional Time-Fractional Differential Equations

Fractional partial differential equations (FPDEs) are highly effective and powerful tools for modeling problems in engineering, physics, and other fields because of their non-local properties. Most FPDEs can not solved analytically. Therefore, developing accurate, efficient, stable, and easy-to-implement methods is an important task. To date, ample numerical methods have been proposed for solving the time and/or space FPDEs, such as the finite difference and finite element methods. A large and sparse system of linear equations will arise when FPDEs are discretised using certain discretisation schemes based on finite element or finite difference methods which requires a considerable amount of execution time since earlier solutions have to be saved if the current solution is to be computed. This thesis focuses on the development of new, accurate, efficient, and fast numerical methods for solving FPDEs