Mining Heterogeneous Multivariate Time-Series for Learning Meaningful Patterns: Application to Home Health Telecare

For the last years, time-series mining has become a challenging issue for researchers. An important application lies in most monitoring purposes, which require analyzing large sets of time-series for learning usual patterns. Any deviation from this learned profile is then considered as an unexpected situation. Moreover, complex applications may involve the temporal study of several heterogeneous parameters. In that paper, we propose a method for mining heterogeneous multivariate time-series for learning meaningful patterns. The proposed approach allows for mixed time-series -- containing both pattern and non-pattern data -- such as for imprecise matches, outliers, stretching and global translating of patterns instances in time. We present the early results of our approach in the context of monitoring the health status of a person at home. The purpose is to build a behavioral profile of a person by analyzing the time variations of several quantitative or qualitative parameters recorded through a provision of sensors installed in the home

Segment-based multiple sequence alignment

Motivation: Many multiple sequence alignment tools have been developed in the past, progressing either in speed or alignment accuracy. Given the importance and wide-spread use of alignment tools, progress in both categories is a contribution to the community and has driven research in the field so far. Results: We introduce a graph-based extension to the consistency-based, progressive alignment strategy. We apply the consistency notion to segments instead of single characters. The main problem we solve in this context is to define segments of the sequences in such a way that a graph-based alignment is possible. We implemented the algorithm using the SeqAn library and report results on amino acid and DNA sequences. The benefit of our approach is threefold: (1) sequences with conserved blocks can be rapidly aligned, (2) the implementation is conceptually easy, generic and fast and (3) the consistency idea can be extended to align multiple genomic sequences. Availability: The segment-based multiple sequence alignment tool can be downloaded from http://www.seqan.de/projects/msa.html. A novel version of T-Coffee interfaced with the tool is available from http://www.tcoffee.org. The usage of the tool is described in both documentations. Contact: [email protected]

Sparse Dynamic Programming on DAGs with Small Width

The minimum path cover problem asks us to find a minimum-cardinality set of paths that cover all the nodes of a directed acyclic graph (DAG). We study the case when the size k of a minimum path cover is small, that is, when the DAG has a small width. This case is motivated by applications in pan-genomics, where the genomic variation of a population is expressed as a DAG. We observe that classical alignment algorithms exploiting sparse dynamic programming can be extended to the sequence-against-DAG case by mimicking the algorithm for sequences on each path of a minimum path cover and handling an evaluation order anomaly with reachability queries. Namely, we introduce a general framework for DAG-extensions of sparse dynamic programming. This framework produces algorithms that are slower than their counterparts on sequences only by a factor k. We illustrate this on two classical problems extended to DAGs: longest increasing subsequence and longest common subsequence. For the former, we obtain an algorithm with running time O(k vertical bar E vertical bar log vertical bar V vertical bar). This matches the optimal solution to the classical problem variant when the input sequence is modeled as a path. We obtain an analogous result for the longest common subsequence problem. We then apply this technique to the co-linear chaining problem, which is a generalization of the above two problems. The algorithm for this problem turns out to be more involved, needing further ingredients, such as an FM-index tailored for large alphabets and a two-dimensional range search tree modified to support range maximum queries. We also study a general sequence-to-DAG alignment formulation that allows affine gap costs in the sequence. The main ingredient of the proposed framework is a new algorithm for finding a minimum path cover of a DAG (V, E) in O(k vertical bar E vertical bar log vertical bar V vertical bar) time, improving all known time-bounds when k is small and the DAG is not too dense. In addition to boosting the sparse dynamic programming framework, an immediate consequence of this new minimum path cover algorithm is an improved space/time tradeoff for reachability queries in arbitrary directed graphs.Peer reviewe

Rollercoasters and Caterpillars

A rollercoaster is a sequence of real numbers for which every maximal contiguous subsequence - increasing or decreasing - has length at least three. By translating this sequence to a set of points in the plane, a rollercoaster can be defined as an x-monotone polygonal path for which every maximal sub-path, with positive- or negative-slope edges, has at least three vertices. Given a sequence of distinct real numbers, the rollercoaster problem asks for a maximum-length (not necessarily contiguous) subsequence that is a rollercoaster. It was conjectured that every sequence of n distinct real numbers contains a rollercoaster of length at least ceil[n/2] for n>7, while the best known lower bound is Omega(n/log n). In this paper we prove this conjecture. Our proof is constructive and implies a linear-time algorithm for computing a rollercoaster of this length. Extending the O(n log n)-time algorithm for computing a longest increasing subsequence, we show how to compute a maximum-length rollercoaster within the same time bound. A maximum-length rollercoaster in a permutation of {1,...,n} can be computed in O(n log log n) time. The search for rollercoasters was motivated by orthogeodesic point-set embedding of caterpillars. A caterpillar is a tree such that deleting the leaves gives a path, called the spine. A top-view caterpillar is one of maximum degree 4 such that the two leaves adjacent to each vertex lie on opposite sides of the spine. As an application of our result on rollercoasters, we are able to find a planar drawing of every n-vertex top-view caterpillar on every set of 25/3(n+4) points in the plane, such that each edge is an orthogonal path with one bend. This improves the previous best known upper bound on the number of required points, which is O(n log n). We also show that such a drawing can be obtained in linear time, when the points are given in sorted order