An optimal factor analysis approach to improve the wavelet-based image resolution enhancement techniques

The existing wavelet-based image resolution enhancement techniques have many assumptions, such as limitation of the way to generate low-resolution images and the selection of wavelet functions, which limits their applications in different fields. This paper initially identifies the factors that effectively affect the performance of these techniques and quantitatively evaluates the impact of the existing assumptions. An approach called Optimal Factor Analysis employing the genetic algorithm is then introduced to increase the applicability and fidelity of the existing methods. Moreover, a new Figure of Merit is proposed to assist the selection of parameters and better measure the overall performance. The experimental results show that the proposed approach improves the performance of the selected image resolution enhancement methods and has potential to be extended to other methods

Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Optimization the initial weights of artificial neural networks via genetic algorithm applied to hip bone fracture prediction

This paper aims to find the optimal set of initial weights to enhance the accuracy of artificial neural networks (ANNs) by using genetic algorithms (GA). The sample in this study included 228 patients with first low-trauma hip fracture and 215 patients without hip fracture, both of them were interviewed with 78 questions. We used logistic regression to select 5 important factors (i.e., bone mineral density, experience of fracture, average hand grip strength, intake of coffee, and peak expiratory flow rate) for building artificial neural networks to predict the probabilities of hip fractures. Three-layer (one hidden layer) ANNs models with back-propagation training algorithms were adopted. The purpose in this paper is to find the optimal initial weights of neural networks via genetic algorithm to improve the predictability. Area under the ROC curve (AUC) was used to assess the performance of neural networks. The study results showed the genetic algorithm obtained an AUC of 0.858±0.00493 on modeling data and 0.802 ± 0.03318 on testing data. They were slightly better than the results of our previous study (0.868±0.00387 and 0.796±0.02559, resp.). Thus, the preliminary study for only using simple GA has been proved to be effective for improving the accuracy of artificial neural networks.This research was supported by the National Science Council (NSC) of Taiwan (Grant no. NSC98-2915-I-155-005), the Department of Education grant of Excellent Teaching Program of Yuan Ze University (Grant no. 217517) and the Center for Dynamical Biomarkers and Translational Medicine supported by National Science Council (Grant no. NSC 100- 2911-I-008-001)

Morphological Network: How Far Can We Go with Morphological Neurons?

In recent years, the idea of using morphological operations as networks has received much attention. Mathematical morphology provides very efficient and useful image processing and image analysis tools based on basic operators like dilation and erosion, defined in terms of kernels. Many other morphological operations are built up using the dilation and erosion operations. Although the learning of structuring elements such as dilation or erosion using the backpropagation algorithm is not new, the order and the way these morphological operations are used is not standard. In this paper, we have theoretically analyzed the use of morphological operations for processing 1D feature vectors and shown that this gets extended to the 2D case in a simple manner. Our theoretical results show that a morphological block represents a sum of hinge functions. Hinge functions are used in many places for classification and regression tasks (Breiman (1993)). We have also proved a universal approximation theorem -- a stack of two morphological blocks can approximate any continuous function over arbitrary compact sets. To experimentally validate the efficacy of this network in real-life applications, we have evaluated its performance on satellite image classification datasets since morphological operations are very sensitive to geometrical shapes and structures. We have also shown results on a few tasks like segmentation of blood vessels from fundus images, segmentation of lungs from chest x-ray and image dehazing. The results are encouraging and further establishes the potential of morphological networks.Comment: 35 pages, 19 figures, 7 table

Less is More: Micro-expression Recognition from Video using Apex Frame

Despite recent interest and advances in facial micro-expression research, there is still plenty room for improvement in terms of micro-expression recognition. Conventional feature extraction approaches for micro-expression video consider either the whole video sequence or a part of it, for representation. However, with the high-speed video capture of micro-expressions (100-200 fps), are all frames necessary to provide a sufficiently meaningful representation? Is the luxury of data a bane to accurate recognition? A novel proposition is presented in this paper, whereby we utilize only two images per video: the apex frame and the onset frame. The apex frame of a video contains the highest intensity of expression changes among all frames, while the onset is the perfect choice of a reference frame with neutral expression. A new feature extractor, Bi-Weighted Oriented Optical Flow (Bi-WOOF) is proposed to encode essential expressiveness of the apex frame. We evaluated the proposed method on five micro-expression databases: CAS(ME)$^2$, CASME II, SMIC-HS, SMIC-NIR and SMIC-VIS. Our experiments lend credence to our hypothesis, with our proposed technique achieving a state-of-the-art F1-score recognition performance of 61% and 62% in the high frame rate CASME II and SMIC-HS databases respectively.Comment: 14 pages double-column, author affiliations updated, acknowledgment of grant support adde