Soma-Axon Coupling Configurations That Enhance Neuronal Coincidence Detection

Coincidence detector neurons transmit timing information by responding preferentially to concurrent synaptic inputs. Principal cells of the medial superior olive (MSO) in the mammalian auditory brainstem are superb coincidence detectors. They encode sound source location with high temporal precision, distinguishing submillisecond timing differences among inputs. We investigate computationally how dynamic coupling between the input region (soma and dendrite) and the spike-generating output region (axon and axon initial segment) can enhance coincidence detection in MSO neurons. To do this, we formulate a two-compartment neuron model and characterize extensively coincidence detection sensitivity throughout a parameter space of coupling configurations. We focus on the interaction between coupling configuration and two currents that provide dynamic, voltage-gated, negative feedback in subthreshold voltage range: sodium current with rapid inactivation and low-threshold potassium current, IKLT. These currents reduce synaptic summation and can prevent spike generation unless inputs arrive with near simultaneity. We show that strong soma-to-axon coupling promotes the negative feedback effects of sodium inactivation and is, therefore, advantageous for coincidence detection. Furthermore, the feedforward combination of strong soma-to-axon coupling and weak axon-to-soma coupling enables spikes to be generated efficiently (few sodium channels needed) and with rapid recovery that enhances high-frequency coincidence detection. These observations detail the functional benefit of the strongly feedforward configuration that has been observed in physiological studies of MSO neurons. We find that IKLT further enhances coincidence detection sensitivity, but with effects that depend on coupling configuration. For instance, in models with weak soma-to-axon and weak axon-to-soma coupling, IKLT in the axon enhances coincidence detection more effectively than IKLT in the soma. By using a minimal model of soma-to-axon coupling, we connect structure, dynamics, and computation. Although we consider the particular case of MSO coincidence detectors, our method for creating and exploring a parameter space of two-compartment models can be applied to other neurons

Enhancing the significance of gravitational wave bursts through signal classification

The quest to observe gravitational waves challenges our ability to discriminate signals from detector noise. This issue is especially relevant for transient gravitational waves searches with a robust eyes wide open approach, the so called all- sky burst searches. Here we show how signal classification methods inspired by broad astrophysical characteristics can be implemented in all-sky burst searches preserving their generality. In our case study, we apply a multivariate analyses based on artificial neural networks to classify waves emitted in compact binary coalescences. We enhance by orders of magnitude the significance of signals belonging to this broad astrophysical class against the noise background. Alternatively, at a given level of mis-classification of noise events, we can detect about 1/4 more of the total signal population. We also show that a more general strategy of signal classification can actually be performed, by testing the ability of artificial neural networks in discriminating different signal classes. The possible impact on future observations by the LIGO-Virgo network of detectors is discussed by analysing recoloured noise from previous LIGO-Virgo data with coherent WaveBurst, one of the flagship pipelines dedicated to all-sky searches for transient gravitational waves

Neural Dynamics of Phonetic Trading Relations for Variable-Rate CV Syllables

The perception of CV syllables exhibits a trading relationship between voice onset time (VOT) of a consonant and duration of a vowel. Percepts of [ba] and [wa] can, for example, depend on the durations of the consonant and vowel segments, with an increase in the duration of the subsequent vowel switching the percept of the preceding consonant from [w] to [b]. A neural model, called PHONET, is proposed to account for these findings. In the model, C and V inputs are filtered by parallel auditory streams that respond preferentially to transient and sustained properties of the acoustic signal, as in vision. These streams are represented by working memories that adjust their processing rates to cope with variable acoustic input rates. More rapid transient inputs can cause greater activation of the transient stream which, in turn, can automatically gain control the processing rate in the sustained stream. An invariant percept obtains when the relative activations of C and V representations in the two streams remain uncha.nged. The trading relation may be simulated as a result of how different experimental manipulations affect this ratio. It is suggested that the brain can use duration of a subsequent vowel to make the [b]/[w] distinction because the speech code is a resonant event that emerges between working mernory activation patterns and the nodes that categorize them.Advanced Research Projects Agency (90-0083); Air Force Office of Scientific Reseearch (F19620-92-J-0225); Pacific Sierra Research Corporation (91-6075-2

Interpreting Deep Visual Representations via Network Dissection

The success of recent deep convolutional neural networks (CNNs) depends on learning hidden representations that can summarize the important factors of variation behind the data. However, CNNs often criticized as being black boxes that lack interpretability, since they have millions of unexplained model parameters. In this work, we describe Network Dissection, a method that interprets networks by providing labels for the units of their deep visual representations. The proposed method quantifies the interpretability of CNN representations by evaluating the alignment between individual hidden units and a set of visual semantic concepts. By identifying the best alignments, units are given human interpretable labels across a range of objects, parts, scenes, textures, materials, and colors. The method reveals that deep representations are more transparent and interpretable than expected: we find that representations are significantly more interpretable than they would be under a random equivalently powerful basis. We apply the method to interpret and compare the latent representations of various network architectures trained to solve different supervised and self-supervised training tasks. We then examine factors affecting the network interpretability such as the number of the training iterations, regularizations, different initializations, and the network depth and width. Finally we show that the interpreted units can be used to provide explicit explanations of a prediction given by a CNN for an image. Our results highlight that interpretability is an important property of deep neural networks that provides new insights into their hierarchical structure.Comment: *B. Zhou and D. Bau contributed equally to this work. 15 pages, 27 figure

A neural circuit for navigation inspired by C. elegans Chemotaxis

We develop an artificial neural circuit for contour tracking and navigation inspired by the chemotaxis of the nematode Caenorhabditis elegans. In order to harness the computational advantages spiking neural networks promise over their non-spiking counterparts, we develop a network comprising 7-spiking neurons with non-plastic synapses which we show is extremely robust in tracking a range of concentrations. Our worm uses information regarding local temporal gradients in sodium chloride concentration to decide the instantaneous path for foraging, exploration and tracking. A key neuron pair in the C. elegans chemotaxis network is the ASEL & ASER neuron pair, which capture the gradient of concentration sensed by the worm in their graded membrane potentials. The primary sensory neurons for our network are a pair of artificial spiking neurons that function as gradient detectors whose design is adapted from a computational model of the ASE neuron pair in C. elegans. Simulations show that our worm is able to detect the set-point with approximately four times higher probability than the optimal memoryless Levy foraging model. We also show that our spiking neural network is much more efficient and noise-resilient while navigating and tracking a contour, as compared to an equivalent non-spiking network. We demonstrate that our model is extremely robust to noise and with slight modifications can be used for other practical applications such as obstacle avoidance. Our network model could also be extended for use in three-dimensional contour tracking or obstacle avoidance

Importance Sampling for Objetive Funtion Estimations in Neural Detector Traing Driven by Genetic Algorithms

To train Neural Networks (NNs) in a supervised way, estimations of an objective function must be carried out. The value of this function decreases as the training progresses and so, the number of test observations necessary for an accurate estimation has to be increased. Consequently, the training computational cost is unaffordable for very low objective function value estimations, and the use of Importance Sampling (IS) techniques becomes convenient. The study of three different objective functions is considered, which implies the proposal of estimators of the objective function using IS techniques: the Mean-Square error, the Cross Entropy error and the Misclassification error criteria. The values of these functions are estimated by IS techniques, and the results are used to train NNs by the application of Genetic Algorithms. Results for a binary detection in Gaussian noise are provided. These results show the evolution of the parameters during the training and the performances of the proposed detectors in terms of error probability and Receiver Operating Characteristics curves. At the end of the study, the obtained results justify the convenience of using IS in the training