Neuroplasticity of language networks in aphasia: advances, updates, and future challenges

Researchers have sought to understand how language is processed in the brain, how brain damage affects language abilities, and what can be expected during the recovery period since the early 19th century. In this review, we first discuss mechanisms of damage and plasticity in the post-stroke brain, both in the acute and the chronic phase of recovery. We then review factors that are associated with recovery. First, we review organism intrinsic variables such as age, lesion volume and location and structural integrity that influence language recovery. Next, we review organism extrinsic factors such as treatment that influence language recovery. Here, we discuss recent advances in our understanding of language recovery and highlight recent work that emphasizes a network perspective of language recovery. Finally, we propose our interpretation of the principles of neuroplasticity, originally proposed by Kleim and Jones (1) in the context of extant literature in aphasia recovery and rehabilitation. Ultimately, we encourage researchers to propose sophisticated intervention studies that bring us closer to the goal of providing precision treatment for patients with aphasia and a better understanding of the neural mechanisms that underlie successful neuroplasticity.P50 DC012283 - NIDCD NIH HHSPublished versio

Medical imaging analysis with artificial neural networks

Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging

Magnification Control in Winner Relaxing Neural Gas

An important goal in neural map learning, which can conveniently be accomplished by magnification control, is to achieve information optimal coding in the sense of information theory. In the present contribution we consider the winner relaxing approach for the neural gas network. Originally, winner relaxing learning is a slight modification of the self-organizing map learning rule that allows for adjustment of the magnification behavior by an a priori chosen control parameter. We transfer this approach to the neural gas algorithm. The magnification exponent can be calculated analytically for arbitrary dimension from a continuum theory, and the entropy of the resulting map is studied numerically conf irming the theoretical prediction. The influence of a diagonal term, which can be added without impacting the magnification, is studied numerically. This approach to maps of maximal mutual information is interesting for applications as the winner relaxing term only adds computational cost of same order and is easy to implement. In particular, it is not necessary to estimate the generally unknown data probability density as in other magnification control approaches.Comment: 14pages, 2 figure