Significación pronóstica de la interleuquina 18 (IL-18) en el Síndrome coronario agudo con elevación de ST (SCACEST)

Multiple sclerosi

High-resolution whole-body mapping of warm and cold thermosensitivity in people with multiple sclerosis

High-resolution whole-body mapping of warm and cold thermosensitivity in people with multiple sclerosi

Modeling multiple sclerosis in laboratory animals

Inflammatory demyelinating disease of the central nervous system is one of the most frequent causes of neurological disability in young adults. While in situ analysis and in vitro models do shed some light onto the processes of tissue damage and cellular interactions, the development of neuroinflammation and demyelination is a far too complex process to be adequately modeled by simple test tube systems. Thus, animal models using primarily genetically modified mice have been proven to be of paramount importance. In this chapter, we discuss recent advances in modeling brain diseases focusing on murine models and report on new tools to study the pathogenesis of complex diseases such as multiple sclerosi

A preliminary analysis of gait performance of patients with multiple sclerosis using a sensorized crutch tip

The quality of life and functional mobility of patients with Multiple Sclerosis (MS) can significantly improve with exercise and a rehabilitation therapy adjusted to the needs of each patient. The assessment of gait and functional mobility of patients with MS is usually done based on clinical scales and tests, which have various limitations. This work presents the preliminary results of a clinical study carried out with patients with MS walking with a sensorized crutch tip. This tip allows to define new indicators that can be correlated with the clinical assessment scales and provide further objective and quantitative information to assess gait performance and level of impairment of patients with MS, and characterize their gait patterns. The results suggest that parameters such as the average cycle time and the average percentage of body weight might be useful to evaluate the gait performance and level of disability. Moreover, parameters related with the pitch angle of the crutch allow to determine crutch usage patterns and spot differences between patients with similar functional performance.This work was supported by the Government of the Basque Country (grant PRE-2018-2-210), by the University of the Basque Country (project GIU19/45), by the Ministerio de Ciencia e Innovacion (MCI) under grant number DPI2017-82694-R (AEI/FEDER, UE), by Fundacion Euskampus and Fundacion BB

TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease

In this review we summarize the essential findings about the function of tumour necrosis factor (TNF) and its cognate receptors TNFR1 and TNFR2, and lymphotoxin α (LT-α) ligands in immune-mediated CNS inflammation and demyelination. The advent of homologous recombination technology in rodents provides a new method which has been used during the last 5 years and has led to insights into the pathophysiology of experimental autoimmune encephalomyelitis (EAE) in an unprecedented way. Studies with knockout mice in which genes of the TNF ligand/receptor superfamily are not expressed and studies with transgenic mice overexpressing TNF and TNFR reveal the critical role of the TNFR1 signalling pathway in the control of CNS demyelination and inflammation. These studies provide novel findings and at the same time shed light on the complex pathophysiology of EAE. Together, these findings may contribute to better understanding of EAE and open new avenues in experimental therapies for multiple sclerosi