An Evolutionary Neural Network Approach for Slopes Stability Assessment

A current big challenge for developed or developing countries is how to keep large-scale transportation infrastructure networks operational under all conditions. Network extensions and budgetary constraints for maintenance purposes are among the main factors that make transportation network management a non-trivial task. On the other hand, the high number of parameters affecting the stability condition of engineered slopes makes their assessment even more complex and difficult to accomplish. Aiming to help achieve the more efficient management of such an important element of modern society, a first attempt at the development of a classification system for rock and soil cuttings, as well as embankments based on visual features, was made in this paper using soft computing algorithms. The achieved results, although interesting, nevertheless have some important limitations to their successful use as auxiliary tools for transportation network management tasks. Accordingly, we carried out new experiments through the combination of modern optimization and soft computing algorithms. Thus, one of the main challenges to overcome is related to the selection of the best set of input features for a feedforward neural network for earthwork hazard category (EHC) identification. We applied a genetic algorithm (GA) for this purpose. Another challenging task is related to the asymmetric distribution of the data (since typically good conditions are much more common than bad ones). To address this question, three training sampling approaches were explored: no resampling, the synthetic minority oversampling technique (SMOTE), and oversampling. Some relevant observations were taken from the optimization process, namely, the identification of which variables are more frequently selected for EHC identification. After finding the most efficient models, a detailed sensitivity analysis was applied over the selected models, allowing us to measure the relative importance of each attribute in EHC identification

Controller tuning by means of multi-objective optimization algorithms: a global tuning framework

© 2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.A holistic multi-objective optimization design technique for controller tuning is presented. This approach gives control engineers greater flexibility to select a controller that matches their specifications. Furthermore, for a given controller it is simple to analyze the tradeoff achieved between conflicting objectives. By using the multi-objective design technique it is also possible to perform a global comparison between different control strategies in a simple and robust way. This approach thereby enables an analysis to be made of whether a preference for a certain control technique is justified. This proposal is evaluated and validated in a nonlinear multiple-input multiple-output system using two control strategies: a classical proportional- integral-derivative control scheme and a feedback state controller.This work was supported in part by the FPI-2010/19 Grant and the Project PAID-06-11 from the Universitat Politecnica de Valencia and in part by the Projects DPI2008-02133, TIN2011-28082, and ENE2011-25900 from the Spanish Ministry of Science and Innovation.Reynoso Meza, G.; García-Nieto Rodríguez, S.; Sanchís Saez, J.; Blasco, X. (2013). Controller tuning by means of multi-objective optimization algorithms: a global tuning framework. IEEE Transactions on Control Systems Technology. 21(2):445-458. https://doi.org/10.1109/TCST.2012.2185698S44545821

Enhancing controller's tuning reliability with multi-objective optimisation: From Model in the loop to Hardware in the loop

[EN] In general, the starting point for the complex task of designing a robust and efficient control system is the use of nominal models that allow to establish a first set of parameters for the selected control scheme. Once the initial stage of design is achieved, control engineers face the difficult task of Fine-Tuning for a more realistic environment, where the environment conditions are as similar as possible to the real system. For this reason, in the last decades the use of Hardware-in-The-Loop (HiL) systems has been introduced. This simulation technique guarantees realistic simulation environments to test the designs but without danger of damaging the equipment. Also, in this iterative process of Fine-Tuning, it is usual to use different (generally conflicting/opposed) criteria that take into account the sensitivities that always appear in every project, such as economic, security, robustness, performance, for example. In this framework, the use of multi-objective techniques are especially useful since they allow to study the different design alternatives based on the multiple existing criteria. Unfortunately, the combination of multi-objective techniques and verification schemes based on Hardware-In-The-Loop presents a high incompatibility. Since obtaining the optimal set of solutions requires a high computational cost that is greatly increased when using Hardware- In-the-Loop. For this reason, it is often necessary to use less realistic but more computationally efficient verification schemes such as Model in the Loop (MiL), Software in the Loop (SiL) and Processor in the Loop (PiL). In this paper, a combined methodology is presented, where multi-objective optimisation and multi-criteria decision making steps are sequentially performed to achieve a final control solution. The authors claim that while going towards the optimisation sequence over MiL -> SiL -> PiL -> HiL platforms, the complexity of the problem is unveiled to the designer, allowing to state meaningful design objectives. In addition, safety in the step between simulation and reality is significantly increased.The authors would like to acknowledge the Spanish Ministry of Economy and Competitiveness for providing funding through the project DPI2015-71443-R and the grant BES-2012-056210. This work has been partially supported by the National Council of Scientific and Technological Development of Brazil (CNPq) through the BJT/304804/2014-2 and PQ-2/304066/2016-8 grants.Reynoso Meza, G.; Velasco-Carrau, J.; Garcia-Nieto, S.; Blasco, X. (2017). Enhancing controller's tuning reliability with multi-objective optimisation: From Model in the loop to Hardware in the loop. Engineering Applications of Artificial Intelligence. 64:52-66. https://doi.org/10.1016/j.engappai.2017.05.005S52666

Asymmetric distances to improve n-dimensional Pareto fronts graphical analysis

isualization tools and techniques to analyze n-dimensional Pareto fronts are valuable for designers and decision makers in order to analyze straightness and drawbacks among design alternatives. Their usefulness is twofold: on the one hand, they provide a practical framework to the decision maker in order to select the preferable solution to be imple- mented; on the other hand, they may improve the decision maker s design insight,i.e. increasing the designer s knowledge on the multi-objective problem at hand. In this work, an order based asymmetric topology for finite dimensional spaces is introduced. This asymmetric topology, associated to what we called asymmetric distance, provides a theoretical and interpretable framework to analyze design alternatives for n-dimensional Pareto fronts. The use of this asymmetric distance will allow a new way to gather dominance and relative distance together. This property can be exploited inside interactive visualization tools. Additionally, a composed norm based on asymmetric distance has been developed. The composed norm allows a fast visualization of designer preferences hypercubes when Level Diagram visualization is used for multidimensional Pareto front analysis. All these proposals are evaluated and validated through different engineering benchmarks; the presented results show the usefulness of this asymmetric topology to improve visualization interpretability.This work was partially supported by EVO-CONTROL project (ref. PROMETEO/2012/028, Generalitat Valenciana - Spain) and the National Council of Scientific and Technologic Development of Brazil (CNPq) with the postdoctoral fellowship BJT-304804/2014-2.Blasco Ferragud, FX.; Reynoso Meza, G.; Sánchez Pérez, EA.; Sánchez Pérez, JV. (2016). Asymmetric distances to improve n-dimensional Pareto fronts graphical analysis. Information Sciences. 340:228-249. doi:10.1016/j.ins.2015.12.039S22824934

Multi-Objective Optimization for Wind Estimation and Aircraft Model Identification

In this paper, a novel method for aerodynamic model identification of a micro-air vehicle is proposed. The principal contribution is a technique of wind estimation that provides information about the existing wind during flight when no air-data sensors are available. The estimation technique employs multi-objective optimization algorithms that utilize identification errors to propose the wind-speed components that best fit the dynamic behavior observed. Once the wind speed is estimated, the flight experimentation data are corrected and utilized to perform an identification of the aircraft model parameters. A multi-objective optimization algorithm is also used, but with the objective of estimating the aerodynamic stability and control derivatives. Employing data from different flights offers the possibility of obtaining sets of models that form the Pareto fronts. Deciding which model best adjusts to the experiments performed (compromise model) will be the ultimate task of the control engineer.The authors would like to thank the Spanish Ministry of Innovation and Science for providing funding through grant BES-2012-056210 and projects TIN-2011-28082 and ENE-25900. We also want to acknowledge the Generalitat Valenciana for financing this work through project PROMETEO/2012/028.Velasco Carrau, J.; García-Nieto Rodríguez, S.; Salcedo Romero De Ávila, JV.; Bishop, RH. (2015). Multi-Objective Optimization for Wind Estimation and Aircraft Model Identification. Journal of Guidance, Control, and Dynamics. 39(2):372-389. https://doi.org/10.2514/1.G001294S37238939

Unmanned Aerial Vehicles Modelling and Control Design. A Multi-Objective Optimization Approach

[ES] Aquesta tesi presenta els resultats de la feina de recerca dut a terme sobre el modelatge i el disseny de controladors per a micro-aeronaus no tripulades mitjançant tècniques d'optimització multi-objectiu. Dos principals camps d'estudi estan presents al llarg d'ella. D'una banda, l'estudi de com modelar i controlar plataformes aèries de petita envergadura. I, de l'altra, l'estudi sobre l'ús de tècniques heurístiques d'optimització multi-objectiu per aplicar en el procés de parametrització de models i controladors en micro-aeronaus no tripulades. S'obtenen com a resultat principal una sèrie d'eines que permeten prescindir d'experiments en túnels de vent o de sensòrica d'alt cost, passant directament a la utilització de dades de vol experimental a la identificació paramètrica de models dinàmics. A més, es demostra com la utilització d'eines d'optimització multi-objectiu en diferents fases de desenvolupament de controladors ajuda a augmentar el coneixement sobre la plataforma a controlar i augmenta la fiabilitat i robustesa dels controladors desenvolupats, disminuint el risc de passar de les fases prèvies de el disseny a la validació en vol real.[CA] Esta tesis presenta los resultados del trabajo de investigación llevado a cabo sobre el modelado y el diseño de controladores para micro-aeronaves no tripuladas mediante técnicas de optimización multi-objetivo. Dos principales campos de estudio están presentes a lo largo de ella. Por un lado, el estudio de cómo modelar y controlar plataformas aéreas de pequeña envergadura. Y, por otro, el estudio sobre el empleo de técnicas heurísticas de optimización multi-objetivo para aplicar en el proceso de parametrización de modelos y controladores en micro-aeronaves no tripuladas. Se obtienen como resultado principal una serie de herramientas que permiten prescindir de experimentos en túneles de viento o de sensórica de alto coste, pasando directamente a la utilización de datos de vuelo experimental en la identificación paramétrica de modelos dinámicos. Además, se demuestra como la utilización de herramientas de optimización multi-objetivo en diferentes fases del desarrollo de controladores ayuda a aumentar el conocimiento sobre la plataforma a controlar y aumenta la fiabilidad y robustez de los controladores desarrollados, disminuyendo el riesgo de pasar de las fases previas del diseño a la validación en vuelo real.[EN] This thesis presents the results of the research work carried out on the modelling and design of controllers for micro-unmanned aerial vehicles by means of multi-objective optimization techniques. Two main fields of study are present throughout it. On one hand, the study of how to model and control small aerial platforms. And, on the other, the study on the use of heuristic multi-objective optimization techniques to apply in the process of models and controllers parameterization in micro-unmanned aerial vehicles. The main result is a series of tools that make it possible manage without wind tunnel experiments or high-cost air-data sensors, going directly to the use of experimental flight data in the parametric identification of dynamic models. In addition, a demonstration is given on how the use of multi-objective optimization tools in different phases of controller development helps to increase knowledge about the platform to be controlled and increases the reliability and robustness of the controllers developed, reducing the risk of hoping from the initial design phases to validation in real flight.Velasco Carrau, J. (2020). Unmanned Aerial Vehicles Modelling and Control Design. A Multi-Objective Optimization Approach [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/156034TESI

A Smart-Distributed Pareto Front Using ev-MOGA Evolutionary Algorithm

[EN] Obtaining multi-objective optimization solutions with a small number of points smartly distributed along the Pareto front is a challenge. Optimization methods, such as the nor- malized normal constraint (NNC), propose the use of a filter to achieve a smart Pareto front distribution. The NCC optimization method presents several disadvantages related with the procedure itself, initial condition dependency, and computational burden. In this article, the epsilon-variable multi-objective genetic algorithm (ev-MOGA) is pre- sented. This algorithm characterizes the Pareto front in a smart way and removes the disadvantages of the NNC method. Finally, examples of a three-bar truss design and controller tuning optimizations are presented for comparison purposes.This work was partially supported by the FPI-2010/19 grant and the PAID-06-11 project from the Universitat Politècnica de València, projects TIN2011-28082 and ENE2011-25900 (Spanish Ministry of Economy and Competitiveness) and the GV/2012/073 (Generalitat Valenciana).Herrero Durá, JM.; Reynoso Meza, G.; Martínez Iranzo, MA.; Blasco Ferragud, FX.; Sanchís Saez, J. (2014). A Smart-Distributed Pareto Front Using ev-MOGA Evolutionary Algorithm. International Journal of Artificial Intelligence Tools. 23(2):1-22. https://doi.org/10.1142/S021821301450002XS122232Marler, R. T., & Arora, J. S. (2009). The weighted sum method for multi-objective optimization: new insights. Structural and Multidisciplinary Optimization, 41(6), 853-862. doi:10.1007/s00158-009-0460-7Messac, A., & Mattson, C. A. (2002). Optimization and Engineering, 3(4), 431-450. doi:10.1023/a:1021179727569Messac, A., Ismail-Yahaya, A., & Mattson, C. A. (2003). The normalized normal constraint method for generating the Pareto frontier. Structural and Multidisciplinary Optimization, 25(2), 86-98. doi:10.1007/s00158-002-0276-1Martínez, M., Sanchis, J., & Blasco, X. (2006). Global and well-distributed Pareto frontier by modified normalized normal constraint methods for bicriterion problems. Structural and Multidisciplinary Optimization, 34(3), 197-209. doi:10.1007/s00158-006-0071-5Martínez, M., García-Nieto, S., Sanchis, J., & Blasco, X. (2009). Genetic algorithms optimization for normalized normal constraint method under Pareto construction. Advances in Engineering Software, 40(4), 260-267. doi:10.1016/j.advengsoft.2008.04.004Mattson, C. A., & Messac, A. (2005). Pareto Frontier Based Concept Selection Under Uncertainty, with Visualization. Optimization and Engineering, 6(1), 85-115. doi:10.1023/b:opte.0000048538.35456.45Mattson, C. A., Mullur, A. A., & Messac, A. (2004). Smart Pareto filter: obtaining a minimal representation of multiobjective design space. Engineering Optimization, 36(6), 721-740. doi:10.1080/0305215042000274942Coello Coello, C. A. (2006). Evolutionary multi-objective optimization: a historical view of the field. IEEE Computational Intelligence Magazine, 1(1), 28-36. doi:10.1109/mci.2006.1597059Zhou, A., Qu, B.-Y., Li, H., Zhao, S.-Z., Suganthan, P. N., & Zhang, Q. (2011). Multiobjective evolutionary algorithms: A survey of the state of the art. Swarm and Evolutionary Computation, 1(1), 32-49. doi:10.1016/j.swevo.2011.03.001Bonissone, P., Subbu, R., & Lizzi, J. (2009). Multicriteria decision making (mcdm): a framework for research and applications. IEEE Computational Intelligence Magazine, 4(3), 48-61. doi:10.1109/mci.2009.933093Laumanns, M., Thiele, L., Deb, K., & Zitzler, E. (2002). Combining Convergence and Diversity in Evolutionary Multiobjective Optimization. Evolutionary Computation, 10(3), 263-282. doi:10.1162/106365602760234108Coello Coello, C. A. (2002). Theoretical and numerical constraint-handling techniques used with evolutionary algorithms: a survey of the state of the art. Computer Methods in Applied Mechanics and Engineering, 191(11-12), 1245-1287. doi:10.1016/s0045-7825(01)00323-1Mezura-Montes, E., & Coello Coello, C. A. (2011). Constraint-handling in nature-inspired numerical optimization: Past, present and future. Swarm and Evolutionary Computation, 1(4), 173-194. doi:10.1016/j.swevo.2011.10.001ÅSTRÖM, K. J., PANAGOPOULOS, H., & HÄGGLUND, T. (1998). Design of PI Controllers based on Non-Convex Optimization. Automatica, 34(5), 585-601. doi:10.1016/s0005-1098(98)00011-9Reynoso-Meza, G., Sanchis, J., Blasco, X., & Herrero, J. M. (2012). Multiobjective evolutionary algorithms for multivariable PI controller design. Expert Systems with Applications, 39(9), 7895-7907. doi:10.1016/j.eswa.2012.01.11

Where the Zigzags go: a microhabitat analysis for the Plethodon dorsalis complex within the Tennessee River gorge

Understudied high-biomass animals such as the Northern Zigzag salamander (Plethodon dorsalis) are known contributors to essential nutrient cycles within their respective habitats. Knowing that these sensitive creatures serve as bioindicators for the overall health and quality of many ecosystems, we should aim to comprehend their habitat requirements. Doing so could ultimately allow conservationists to set more accurate baselines for various mitigation and land management practices. Due to our location within the southeast amphibian biodiversity hot spot, sampling of P. dorsalis is conducted in the Tennessee River Gorge (TRG). Sampling of survey polygons began on October 28, 2018 and concluded on June 8, 2019. Three 2,000 m² sites are selected based on presence of target species and a GIS processed land cover dataset in an attempt to best represent the diverse landscape of selected slopes within the 27,000 acre TRG. Specimens are located using a time based natural cover object survey method. Microhabitat is analyzed within 1 m² of each location containing a P. dorsalis specimen along an elevation gradient (250-300, 300-350 and 350-400 m). For each animal-present location, a randomly selected animal-absent plot is analyzed. This assessment attempts to identify differences in microhabitat preference based on selected versus available habitat using predictive geospatial models and AICc values. These AICс values demonstrate the performance of covariates measured and model fit in relation to salamander presence. Results suggest that different factors influence the distribution of P. dorsalis with respect to microhabitat selection

Identificación de modelos dinámicos y ajuste de controladores basado en algoritmos evolutivos multiobjetivo

[ES] Identificación de las expresiones que modelan los coeficientes aerodinámicos de una aeronave no tripulada (UAV) mediante diferentes metodologías. La primera de ellas hace uso de una regresión cuadrática, mientras que la segunda emplea un algoritmo de Diferenciación Evolutiva en la optimización de diversos objetivos.[EN] Identification of the expressions that model de aerodinamic coefficients of an Unmanned Aerial Vehicle (UAV) by means of two different aproaches. The first one makes use of a quadratic regression while the second one uses a Diferential Evolution algorithm in the optimization of multiple objectivesVelasco Carrau, J. (2013). Identificación de modelos dinámicos y ajuste de controladores basado en algoritmos evolutivos multiobjetivo. http://hdl.handle.net/10251/36468Archivo delegad

Modelling and multiobjective optimization for simulation of cyanobacterial metabolism

The present thesis is devoted to the development of models and algorithms to improve metabolic simulations of cyanobacterial metabolism. Cyanobacteria are photosynthetic bacteria of great biotechnological interest to the development of sustainable bio-based manufacturing processes. For this purpose, it is fundamental to understand metabolic behaviour of these organisms, and constraint-based metabolic modelling techniques offer a platform for analysis and assessment of cell's metabolic functionality. Reliable simulations are needed to enhance the applicability of the results, and this is the main goal of this thesis. This dissertation has been structured in three parts. The first part is devoted to introduce needed fundamentals of the disciplines that are combined in this work: metabolic modelling, cyanobacterial metabolism and multi-objective optimisation. In the second part the reconstruction and update of metabolic models of two cyanobacterial strains is addressed. These models are then used to perform metabolic simulations with the application of the classic Flux Balance Analysis (FBA) methodology. The studies conducted in this part are useful to illustrate the uses and applications of metabolic simulations for the analysis of living organisms. And at the same time they serve to identify important limitations of classic simulation techniques based on mono-objective linear optimisation that motivate the search of new strategies. Finally, in the third part a novel approach is defined based on the application of multi-objective optimisation procedures to metabolic modelling. Main steps in the definition of multi-objective problem and the description of an optimisation algorithm that ensure the applicability of the obtained results, as well as the multi-criteria analysis of the solutions are covered. The resulting tool allows the definition of non-linear objective functions and constraints, as well as the analysis of multiple Pareto-optimal solutions. It avoids some of the main drawbacks of classic methodologies, leading to more flexible simulations and more realistic results. Overall this thesis contributes to the advance in the study of cyanobacterial metabolism by means of definition of models and strategies that improve plasticity and predictive capacities of metabolic simulations.La presente tesis está dedicada al desarrollo de modelos y algoritmos para mejorar las simulaciones metabólicas de cianobacterias. Las cianobacterias son bacterias fotosintéticas de gran interés biotecnológico para el desarrollo de bioprocesos productivos sostenibles. Para este propósito, es fundamental entender el comportamiento metabólico de estos organismos, y el modelado metabólico basado en restricciones ofrece una plataforma para el análisis y la evaluación de las funcionalidades metabólicas de las células. Se necesitan simulaciones fidedignas para aumentar la aplicabilidad de los resultados, y este es el objetivo principal de esta tesis. Esta disertación se ha estructurado en tres partes. La primera parte está dedicada a introducir los fundamentos necesarios de las disciplinas que se combinan en este trabajo: el modelado metabólico, el metabolismo de cianobacterias, y la optimización multiobjetivo. En la segunda parte, se encara la reconstrucción y la actualización de los modelos metabólicos de dos cepas de cianobacterias. Estos modelos se usan después para llevar a cabo simulaciones metabólicas con la aplicación de la metodología clásica Flux Balance Analysis (FBA). Los estudios realizados en esta parte son útiles para ilustrar los usos y aplicaciones de las simulaciones metabólicas para el análisis de los organismos vivos. Y al mismo tiempo sirven para identificar importantes limitaciones de las técnicas clásicas de simulación basadas en optimización lineal mono-objetivo que motivan la búsqueda de nuevas estrategias. Finalmente, en la tercera parte, se define una nueva aproximación basada en la aplicación al modelado metabólico de procedimientos de optimización multiobjetivo. Se cubren los principales pasos en la definición de un problema multiobjetivo y la descripción de un algoritmo de optimización que aseguren la aplicabilidad de los resultados obtenidos, así como el análisis multi-criterio de las soluciones. La herramienta resultante permite la definición de funciones objetivo y restricciones no lineales, así como el análisis de múltiples soluciones en el sentido de Pareto. Esta herramienta evita algunos de los principales inconvenientes de las metodologías clásicas, lo que lleva a obtener simulaciones más flexibles y resultados más realistas. En conjunto, esta tesis contribuye al avance en el estudio del metabolismo de cianobacterias por medio de la definición de modelos y estrategias que mejoran la plasticidad y las capacidades predictivas de las simulaciones metabólicas.La present tesi està dedicada al desenvolupament de models i algorismes per a millorar les simulacions metabòliques de cianobacteris. Els cianobacteris són bacteris fotosintètics de gran interés biotecnològic per al desenvolupament de bioprocessos productius sostenibles. Per a aquest propòsit, és fonamental entendre el comportament metabòlic d'aquests organismes, i el modelatge metabòlic basat en restriccions ofereix una plataforma per a l'anàlisi i l'avaluació de les funcionalitats metabòliques de les cèl·lules. Es necessiten simulacions fidedignes per a augmentar l'aplicabilitat dels resultats, i aquest és l'objectiu principal d'aquesta tesi. Aquesta dissertació s'ha estructurat en tres parts. La primera part està dedicada a introduir els fonaments necessaris de les disciplines que es combinen en aquest treball: el modelatge metabòlic, el metabolisme de cianobacteris i l'optimització multiobjectiu. En la segona part, s'adreça la reconstrucció i l'actualització dels models metabòlics de dos soques de cianobacteris. Aquests models s'empren després per a portar a terme simulacions metabòliques amb l'aplicació de la metodologia clàssica Flux Balance Analysis (FBA). Els estudis realitzats en aquesta part són útils per a il·lustrar els usos i aplicacions de les simulacions metabòliques per a l'anàlisi dels organismes vius. I al mateix temps serveixen per a identificar importants limitacions de les tècniques clàssiques de simulació basades en optimització lineal mono-objectiu que motiven la cerca de noves estratègies. Finalment, en la tercera part, es defineix una nova aproximació basada en l'aplicació al modelatge metabòlic de procediments d'optimització multiobjectiu. Es cobreixen els principals passos en la definició d'un problema multiobjectiu i la descripció d'un algorisme d'optimització que asseguren l'aplicabilitat dels resultats obtinguts, així com l'anàlisi multi-criteri de les solucions. La ferramenta resultant permet la definició de funcions objectiu i restriccions no lineals, així com l'anàlisi de múltiples solucions òptimes en el sentit de Pareto. Aquesta ferramenta evita alguns dels principals inconvenients de les metodologies clàssiques, el que porta a obtenir simulacions més flexibles i resultats més realistes. En conjunt, aquesta tesi contribueix a l'avanç en l'estudi del metabolisme de cianobacteris per mitjà de la definició de models i estratègies que milloren la plasticitat i les capacitats predictives de les simulacions metabòliques.Siurana Paula, M. (2017). Modelling and multiobjective optimization for simulation of cyanobacterial metabolism [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/9057