22,929 research outputs found
VIOLA - A multi-purpose and web-based visualization tool for neuronal-network simulation output
Neuronal network models and corresponding computer simulations are invaluable
tools to aid the interpretation of the relationship between neuron properties,
connectivity and measured activity in cortical tissue. Spatiotemporal patterns
of activity propagating across the cortical surface as observed experimentally
can for example be described by neuronal network models with layered geometry
and distance-dependent connectivity. The interpretation of the resulting stream
of multi-modal and multi-dimensional simulation data calls for integrating
interactive visualization steps into existing simulation-analysis workflows.
Here, we present a set of interactive visualization concepts called views for
the visual analysis of activity data in topological network models, and a
corresponding reference implementation VIOLA (VIsualization Of Layer Activity).
The software is a lightweight, open-source, web-based and platform-independent
application combining and adapting modern interactive visualization paradigms,
such as coordinated multiple views, for massively parallel neurophysiological
data. For a use-case demonstration we consider spiking activity data of a
two-population, layered point-neuron network model subject to a spatially
confined excitation originating from an external population. With the multiple
coordinated views, an explorative and qualitative assessment of the
spatiotemporal features of neuronal activity can be performed upfront of a
detailed quantitative data analysis of specific aspects of the data.
Furthermore, ongoing efforts including the European Human Brain Project aim at
providing online user portals for integrated model development, simulation,
analysis and provenance tracking, wherein interactive visual analysis tools are
one component. Browser-compatible, web-technology based solutions are therefore
required. Within this scope, with VIOLA we provide a first prototype.Comment: 38 pages, 10 figures, 3 table
Data-driven modelling of biological multi-scale processes
Biological processes involve a variety of spatial and temporal scales. A
holistic understanding of many biological processes therefore requires
multi-scale models which capture the relevant properties on all these scales.
In this manuscript we review mathematical modelling approaches used to describe
the individual spatial scales and how they are integrated into holistic models.
We discuss the relation between spatial and temporal scales and the implication
of that on multi-scale modelling. Based upon this overview over
state-of-the-art modelling approaches, we formulate key challenges in
mathematical and computational modelling of biological multi-scale and
multi-physics processes. In particular, we considered the availability of
analysis tools for multi-scale models and model-based multi-scale data
integration. We provide a compact review of methods for model-based data
integration and model-based hypothesis testing. Furthermore, novel approaches
and recent trends are discussed, including computation time reduction using
reduced order and surrogate models, which contribute to the solution of
inference problems. We conclude the manuscript by providing a few ideas for the
development of tailored multi-scale inference methods.Comment: This manuscript will appear in the Journal of Coupled Systems and
Multiscale Dynamics (American Scientific Publishers
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