417 research outputs found
Multi-branch Convolutional Neural Network for Multiple Sclerosis Lesion Segmentation
In this paper, we present an automated approach for segmenting multiple
sclerosis (MS) lesions from multi-modal brain magnetic resonance images. Our
method is based on a deep end-to-end 2D convolutional neural network (CNN) for
slice-based segmentation of 3D volumetric data. The proposed CNN includes a
multi-branch downsampling path, which enables the network to encode information
from multiple modalities separately. Multi-scale feature fusion blocks are
proposed to combine feature maps from different modalities at different stages
of the network. Then, multi-scale feature upsampling blocks are introduced to
upsize combined feature maps to leverage information from lesion shape and
location. We trained and tested the proposed model using orthogonal plane
orientations of each 3D modality to exploit the contextual information in all
directions. The proposed pipeline is evaluated on two different datasets: a
private dataset including 37 MS patients and a publicly available dataset known
as the ISBI 2015 longitudinal MS lesion segmentation challenge dataset,
consisting of 14 MS patients. Considering the ISBI challenge, at the time of
submission, our method was amongst the top performing solutions. On the private
dataset, using the same array of performance metrics as in the ISBI challenge,
the proposed approach shows high improvements in MS lesion segmentation
compared with other publicly available tools.Comment: This paper has been accepted for publication in NeuroImag
Deep learning approaches for segmentation of multiple sclerosis lesions on brain MRI
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system which causes lesions in brain tissues, especially visible in white matter with magnetic resonance imaging (MRI). The diagnosis of MS lesions, which is often performed visually with MRI, is an important task as it can help characterizing the progression of the disease and monitoring the efficacy of a candidate treatment. automatic detection and segmentation of MS lesions from MRI images offer the potential for a faster and more cost-effective performance which could also be immune to expert bias segmentation.
In this thesis, we study automated approaches to segment MS lesions from MRI images. The thesis begins with a review of the existing literature on MS lesion segmentation and discusses their general limitations. We then propose three novel approaches that rely on Convolutional Neural Networks (CNNs) to segment MS lesions.
The first approach demonstrates that the parameters of a CNN learned from natural images, transfer well to the tasks of MS lesion segmentation. In the second approach, we describe a novel multi-branch CNN architecture with end-to-end training that can take advantage of each MRI modalities individually. In that work, we also investigated the combination of MRI modalities leading to the best segmentation performance. In the third approach, we show an effective and novel generalization method for MS lesion segmentation when data are collected from multiple MRI scanning sites and as suffer from (site-)domain shifts. Finally, this thesis concludes with open questions that may benefit from future work. This thesis demonstrates the potential role of CNNs as a common methodological building block to address clinical problems in MS segmentation
HyperDense-Net: A hyper-densely connected CNN for multi-modal image segmentation
Recently, dense connections have attracted substantial attention in computer
vision because they facilitate gradient flow and implicit deep supervision
during training. Particularly, DenseNet, which connects each layer to every
other layer in a feed-forward fashion, has shown impressive performances in
natural image classification tasks. We propose HyperDenseNet, a 3D fully
convolutional neural network that extends the definition of dense connectivity
to multi-modal segmentation problems. Each imaging modality has a path, and
dense connections occur not only between the pairs of layers within the same
path, but also between those across different paths. This contrasts with the
existing multi-modal CNN approaches, in which modeling several modalities
relies entirely on a single joint layer (or level of abstraction) for fusion,
typically either at the input or at the output of the network. Therefore, the
proposed network has total freedom to learn more complex combinations between
the modalities, within and in-between all the levels of abstraction, which
increases significantly the learning representation. We report extensive
evaluations over two different and highly competitive multi-modal brain tissue
segmentation challenges, iSEG 2017 and MRBrainS 2013, with the former focusing
on 6-month infant data and the latter on adult images. HyperDenseNet yielded
significant improvements over many state-of-the-art segmentation networks,
ranking at the top on both benchmarks. We further provide a comprehensive
experimental analysis of features re-use, which confirms the importance of
hyper-dense connections in multi-modal representation learning. Our code is
publicly available at https://www.github.com/josedolz/HyperDenseNet.Comment: Paper accepted at IEEE TMI in October 2018. Last version of this
paper updates the reference to the IEEE TMI paper which compares the
submissions to the iSEG 2017 MICCAI Challeng
Applications of Deep Learning Techniques for Automated Multiple Sclerosis Detection Using Magnetic Resonance Imaging: A Review
Multiple Sclerosis (MS) is a type of brain disease which causes visual, sensory, and motor problems for people with a detrimental effect on the functioning of the nervous system. In order to diagnose MS, multiple screening methods have been proposed so far; among them, magnetic resonance imaging (MRI) has received considerable attention among physicians. MRI modalities provide physicians with fundamental information about the structure and function of the brain, which is crucial for the rapid diagnosis of MS lesions. Diagnosing MS using MRI is time-consuming, tedious, and prone to manual errors. Research on the implementation of computer aided diagnosis system (CADS) based on artificial intelligence (AI) to diagnose MS involves conventional machine learning and deep learning (DL) methods. In conventional machine learning, feature extraction, feature selection, and classification steps are carried out by using trial and error; on the contrary, these steps in DL are based on deep layers whose values are automatically learn. In this paper, a complete review of automated MS diagnosis methods performed using DL techniques with MRI neuroimaging modalities is provided. Initially, the steps involved in various CADS proposed using MRI modalities and DL techniques for MS diagnosis are investigated. The important preprocessing techniques employed in various works are analyzed. Most of the published papers on MS diagnosis using MRI modalities and DL are presented. The most significant challenges facing and future direction of automated diagnosis of MS using MRI modalities and DL techniques are also provided
Spinal cord gray matter segmentation using deep dilated convolutions
Gray matter (GM) tissue changes have been associated with a wide range of
neurological disorders and was also recently found relevant as a biomarker for
disability in amyotrophic lateral sclerosis. The ability to automatically
segment the GM is, therefore, an important task for modern studies of the
spinal cord. In this work, we devise a modern, simple and end-to-end fully
automated human spinal cord gray matter segmentation method using Deep
Learning, that works both on in vivo and ex vivo MRI acquisitions. We evaluate
our method against six independently developed methods on a GM segmentation
challenge and report state-of-the-art results in 8 out of 10 different
evaluation metrics as well as major network parameter reduction when compared
to the traditional medical imaging architectures such as U-Nets.Comment: 13 pages, 8 figure
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