Most Likely Separation of Intensity and Warping Effects in Image Registration

This paper introduces a class of mixed-effects models for joint modeling of spatially correlated intensity variation and warping variation in 2D images. Spatially correlated intensity variation and warp variation are modeled as random effects, resulting in a nonlinear mixed-effects model that enables simultaneous estimation of template and model parameters by optimization of the likelihood function. We propose an algorithm for fitting the model which alternates estimation of variance parameters and image registration. This approach avoids the potential estimation bias in the template estimate that arises when treating registration as a preprocessing step. We apply the model to datasets of facial images and 2D brain magnetic resonance images to illustrate the simultaneous estimation and prediction of intensity and warp effects

Deep-learning-based 2.5D flow field estimation for maximum intensity projections of 4D optical coherence tomography

In microsurgery, lasers have emerged as precise tools for bone ablation. A challenge is automatic control of laser bone ablation with 4D optical coherence tomography (OCT). OCT as high resolution imaging modality provides volumetric images of tissue and foresees information of bone position and orientation (pose) as well as thickness. However, existing approaches for OCT based laser ablation control rely on external tracking systems or invasively ablated artificial landmarks for tracking the pose of the OCT probe relative to the tissue. This can be superseded by estimating the scene flow caused by relative movement between OCT-based laser ablation system and patient. Therefore, this paper deals with 2.5D scene flow estimation of volumetric OCT images for application in laser ablation. We present a semi-supervised convolutional neural network based tracking scheme for subsequent 3D OCT volumes and apply it to a realistic semi-synthetic data set of ex vivo human temporal bone specimen. The scene flow is estimated in a two-stage approach. In the first stage, 2D lateral scene flow is computed on census-transformed en-face arguments-of-maximum intensity projections. Subsequent to this, the projections are warped by predicted lateral flow and 1D depth flow is estimated. The neural network is trained semi-supervised by combining error to ground truth and the reconstruction error of warped images with assumptions of spatial flow smoothness. Quantitative evaluation reveals a mean endpoint error of (4.7 ± 3.5) voxel or (27.5 ± 20.5) μm for scene flow estimation caused by simulated relative movement between the OCT probe and bone. The scene flow estimation for 4D OCT enables its use for markerless tracking of mastoid bone structures for image guidance in general, and automated laser ablation control. © 2019 SPIE

PatchMatch algorithms for motion estimation and stereo reconstruction

Correspondence problems are difficult and fundamental topics in computer vision, which aim to find the displacement field between two consecutive images within an image sequence. Both stereo matching and motion estimation belong to the domain of correspondence problems. A common technique is to define a parametric model and estimate its parameters via some optimization algorithms. In this context, this thesis extends the recently proposed PatchMatch algorithm, which is originally designed for finding approximate nearest neighbors, to model parameter estimation. Specifically, there are three purposes of this thesis: (i) We analyze and extend the PatchMatch algorithm to model parameter estimation. (ii) Afterwards, some commonly used parametric models for motion estimation and stereo matching in the literature are reviewed. (iii) Finally, the extended PatchMatch algorithm is implemented and applied to estimate the model parameters summarized above. The estimation performance is evaluated and compared with some other methods in the literature based on the three public benchmarks: Middlebury, KITTI and MPI Sintel

Variational image fusion

The main goal of this work is the fusion of multiple images to a single composite that offers more information than the individual input images. We approach those fusion tasks within a variational framework. First, we present iterative schemes that are well-suited for such variational problems and related tasks. They lead to efficient algorithms that are simple to implement and well-parallelisable. Next, we design a general fusion technique that aims for an image with optimal local contrast. This is the key for a versatile method that performs well in many application areas such as multispectral imaging, decolourisation, and exposure fusion. To handle motion within an exposure set, we present the following two-step approach: First, we introduce the complete rank transform to design an optic flow approach that is robust against severe illumination changes. Second, we eliminate remaining misalignments by means of brightness transfer functions that relate the brightness values between frames. Additional knowledge about the exposure set enables us to propose the first fully coupled method that jointly computes an aligned high dynamic range image and dense displacement fields. Finally, we present a technique that infers depth information from differently focused images. In this context, we additionally introduce a novel second order regulariser that adapts to the image structure in an anisotropic way.Das Hauptziel dieser Arbeit ist die Fusion mehrerer Bilder zu einem Einzelbild, das mehr Informationen bietet als die einzelnen Eingangsbilder. Wir verwirklichen diese Fusionsaufgaben in einem variationellen Rahmen. Zunächst präsentieren wir iterative Schemata, die sich gut für solche variationellen Probleme und verwandte Aufgaben eignen. Danach entwerfen wir eine Fusionstechnik, die ein Bild mit optimalem lokalen Kontrast anstrebt. Dies ist der Schlüssel für eine vielseitige Methode, die gute Ergebnisse für zahlreiche Anwendungsbereiche wie Multispektralaufnahmen, Bildentfärbung oder Belichtungsreihenfusion liefert. Um Bewegungen in einer Belichtungsreihe zu handhaben, präsentieren wir folgenden Zweischrittansatz: Zuerst stellen wir die komplette Rangtransformation vor, um eine optische Flussmethode zu entwerfen, die robust gegenüber starken Beleuchtungsänderungen ist. Dann eliminieren wir verbleibende Registrierungsfehler mit der Helligkeitstransferfunktion, welche die Helligkeitswerte zwischen Bildern in Beziehung setzt. Zusätzliches Wissen über die Belichtungsreihe ermöglicht uns, die erste vollständig gekoppelte Methode vorzustellen, die gemeinsam ein registriertes Hochkontrastbild sowie dichte Bewegungsfelder berechnet. Final präsentieren wir eine Technik, die von unterschiedlich fokussierten Bildern Tiefeninformation ableitet. In diesem Kontext stellen wir zusätzlich einen neuen Regularisierer zweiter Ordnung vor, der sich der Bildstruktur anisotrop anpasst

Variational image fusion

The main goal of this work is the fusion of multiple images to a single composite that offers more information than the individual input images. We approach those fusion tasks within a variational framework. First, we present iterative schemes that are well-suited for such variational problems and related tasks. They lead to efficient algorithms that are simple to implement and well-parallelisable. Next, we design a general fusion technique that aims for an image with optimal local contrast. This is the key for a versatile method that performs well in many application areas such as multispectral imaging, decolourisation, and exposure fusion. To handle motion within an exposure set, we present the following two-step approach: First, we introduce the complete rank transform to design an optic flow approach that is robust against severe illumination changes. Second, we eliminate remaining misalignments by means of brightness transfer functions that relate the brightness values between frames. Additional knowledge about the exposure set enables us to propose the first fully coupled method that jointly computes an aligned high dynamic range image and dense displacement fields. Finally, we present a technique that infers depth information from differently focused images. In this context, we additionally introduce a novel second order regulariser that adapts to the image structure in an anisotropic way.Das Hauptziel dieser Arbeit ist die Fusion mehrerer Bilder zu einem Einzelbild, das mehr Informationen bietet als die einzelnen Eingangsbilder. Wir verwirklichen diese Fusionsaufgaben in einem variationellen Rahmen. Zunächst präsentieren wir iterative Schemata, die sich gut für solche variationellen Probleme und verwandte Aufgaben eignen. Danach entwerfen wir eine Fusionstechnik, die ein Bild mit optimalem lokalen Kontrast anstrebt. Dies ist der Schlüssel für eine vielseitige Methode, die gute Ergebnisse für zahlreiche Anwendungsbereiche wie Multispektralaufnahmen, Bildentfärbung oder Belichtungsreihenfusion liefert. Um Bewegungen in einer Belichtungsreihe zu handhaben, präsentieren wir folgenden Zweischrittansatz: Zuerst stellen wir die komplette Rangtransformation vor, um eine optische Flussmethode zu entwerfen, die robust gegenüber starken Beleuchtungsänderungen ist. Dann eliminieren wir verbleibende Registrierungsfehler mit der Helligkeitstransferfunktion, welche die Helligkeitswerte zwischen Bildern in Beziehung setzt. Zusätzliches Wissen über die Belichtungsreihe ermöglicht uns, die erste vollständig gekoppelte Methode vorzustellen, die gemeinsam ein registriertes Hochkontrastbild sowie dichte Bewegungsfelder berechnet. Final präsentieren wir eine Technik, die von unterschiedlich fokussierten Bildern Tiefeninformation ableitet. In diesem Kontext stellen wir zusätzlich einen neuen Regularisierer zweiter Ordnung vor, der sich der Bildstruktur anisotrop anpasst

Computer-assisted detection of lung cancer nudules in medical chest X-rays

Diagnostic medicine was revolutionized in 1895 with Rontgen's discovery of x-rays. X-ray photography has played a very prominent role in diagnostics of all kinds since then and continues to do so. It is true that more sophisticated and successful medical imaging systems are available. These include Magnetic Resonance Imaging (MRI), Computerized Tomography (CT) and Positron Emission Tomography (PET). However, the hardware instalment and operation costs of these systems remain considerably higher than x-ray systems. Conventional x-ray photography also has the advantage of producing an image in significantly less time than MRI, CT and PET. X-ray photography is still used extensively, especially in third world countries. The routine diagnostic tool for chest complaints is the x-ray. Lung cancer may be diagnosed by the identification of a lung cancer nodule in a chest x-ray. The cure of lung cancer depends upon detection and diagnosis at an early stage. Presently the five-year survival rate of lung cancer patients is approximately 10%. If lung cancer can be detected when the tumour is still small and localized, the five-year survival rate increases to about 40%. However, currently only 20% of lung cancer cases are diagnosed at this early stage. Giger et al wrote that "detection and diagnosis of cancerous lung nodules in chest radiographs are among the most important and difficult tasks performed by radiologists"