4,216 research outputs found
Molecular Communication Using Brownian Motion with Drift
Inspired by biological communication systems, molecular communication has
been proposed as a viable scheme to communicate between nano-sized devices
separated by a very short distance. Here, molecules are released by the
transmitter into the medium, which are then sensed by the receiver. This paper
develops a preliminary version of such a communication system focusing on the
release of either one or two molecules into a fluid medium with drift. We
analyze the mutual information between transmitter and the receiver when
information is encoded in the time of release of the molecule. Simplifying
assumptions are required in order to calculate the mutual information, and
theoretical results are provided to show that these calculations are upper
bounds on the true mutual information. Furthermore, optimized degree
distributions are provided, which suggest transmission strategies for a variety
of drift velocities.Comment: 20 pages, 7 figures, Accepted for publication in IEEE Trans. on
NanoBioscienc
The case for absolute ligand discrimination : modeling information processing and decision by immune T cells
Some cells have to take decision based on the quality of surroundings
ligands, almost irrespective of their quantity, a problem we name "absolute
discrimination". An example of absolute discrimination is recognition of
not-self by immune T Cells. We show how the problem of absolute discrimination
can be solved by a process called "adaptive sorting". We review several
implementations of adaptive sorting, as well as its generic properties such as
antagonism. We show how kinetic proofreading with negative feedback implements
an approximate version of adaptive sorting in the immune context. Finally, we
revisit the decision problem at the cell population level, showing how
phenotypic variability and feedbacks between population and single cells are
crucial for proper decision
Designing stem cell niches for differentiation and self-renewal
Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in contact with their specialized microenvironment, termed the stem cell niche. Niches provide structural and functional cues that are both biochemical and biophysical, stem cells integrate this complex array of signals with intrinsic regulatory networks to meet physiological demands. Although, some of these regulatory mechanisms remain poorly understood or difficult to harness with traditional culture systems. Biomaterial strategies are being developed that aim to recapitulate stem cell niches, by engineering microenvironments with physiological-like niche properties that aim to elucidate stem cell-regulatory mechanisms, and to harness their regenerative capacity in vitro. In the future, engineered niches will prove important tools for both regenerative medicine and therapeutic discoveries
Molecular communication in fluid media: The additive inverse Gaussian noise channel
We consider molecular communication, with information conveyed in the time of
release of molecules. The main contribution of this paper is the development of
a theoretical foundation for such a communication system. Specifically, we
develop the additive inverse Gaussian (IG) noise channel model: a channel in
which the information is corrupted by noise with an inverse Gaussian
distribution. We show that such a channel model is appropriate for molecular
communication in fluid media - when propagation between transmitter and
receiver is governed by Brownian motion and when there is positive drift from
transmitter to receiver. Taking advantage of the available literature on the IG
distribution, upper and lower bounds on channel capacity are developed, and a
maximum likelihood receiver is derived. Theory and simulation results are
presented which show that such a channel does not have a single quality measure
analogous to signal-to-noise ratio in the AWGN channel. It is also shown that
the use of multiple molecules leads to reduced error rate in a manner akin to
diversity order in wireless communications. Finally, we discuss some open
problems in molecular communications that arise from the IG system model.Comment: 28 pages, 8 figures. Submitted to IEEE Transactions on Information
Theory. Corrects minor typos in the first versio
Communication and quorum sensing in non-living mimics of eukaryotic cells.
Cells in tissues or biofilms communicate with one another through chemical and mechanical signals to coordinate collective behaviors. Non-living cell mimics provide simplified models of natural systems; however, it has remained challenging to implement communication capabilities comparable to living cells. Here we present a porous artificial cell-mimic containing a nucleus-like DNA-hydrogel compartment that is able to express and display proteins, and communicate with neighboring cell-mimics through diffusive protein signals. We show that communication between cell-mimics allows distribution of tasks, quorum sensing, and cellular differentiation according to local environment. Cell-mimics can be manufactured in large quantities, easily stored, chemically modified, and spatially organized into diffusively connected tissue-like arrangements, offering a means for studying communication in large ensembles of artificial cells
A new landscape of host–protozoa interactions involving the extracellular vesicles world
This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © Cambridge University Press 2018Extracellular vesicles (EVs) are released by a wide number of cells including blood cells, immune system cells, tumour cells, adult and embryonic stem cells. EVs are a heterogeneous group of vesicles (~30–1000 nm) including microvesicles and exosomes. The physiological release of EVs represents a normal state of the cell, raising a metabolic equilibrium between catabolic and anabolic processes. Moreover, when the cells are submitted to stress with different inducers or in pathological situations (malignancies, chronic diseases, infectious diseases.), they respond with an intense and dynamic release of EVs. The EVs released from stimulated cells vs those that are released constitutively may themselves differ, both physically and in their cargo. EVs contain protein, lipids, nucleic acids and biomolecules that can alter cell phenotypes or modulate neighbouring cells. In this review, we have summarized findings involving EVs in certain protozoan diseases. We have commented on strategies to study the communicative roles of EVs during host–pathogen interaction and hypothesized on the use of EVs for diagnostic, preventative and therapeutic purposes in infectious diseases. This kind of communication could modulate the innate immune system and reformulate concepts in parasitism. Moreover, the information provided within EVs could produce alternatives in translational medicine.Peer reviewedFinal Accepted Versio
- …