Observation of Nonlocal Modulation with Entangled Photons

We demonstrate a new type of quantum mechanical correlation where phase modulators at distant locations, acting on the photons of an entangled pair, interfere to determine the apparent depth of modulation. When the modulators have the same phase, the modulation depth doubles; when oppositely phased, the modulators negate each other.Comment: 4 pages, 4 figure

Solving Problems on Graphs of High Rank-Width

A modulator of a graph G to a specified graph class H is a set of vertices whose deletion puts G into H. The cardinality of a modulator to various tractable graph classes has long been used as a structural parameter which can be exploited to obtain FPT algorithms for a range of hard problems. Here we investigate what happens when a graph contains a modulator which is large but "well-structured" (in the sense of having bounded rank-width). Can such modulators still be exploited to obtain efficient algorithms? And is it even possible to find such modulators efficiently? We first show that the parameters derived from such well-structured modulators are strictly more general than the cardinality of modulators and rank-width itself. Then, we develop an FPT algorithm for finding such well-structured modulators to any graph class which can be characterized by a finite set of forbidden induced subgraphs. We proceed by showing how well-structured modulators can be used to obtain efficient parameterized algorithms for Minimum Vertex Cover and Maximum Clique. Finally, we use well-structured modulators to develop an algorithmic meta-theorem for deciding problems expressible in Monadic Second Order (MSO) logic, and prove that this result is tight in the sense that it cannot be generalized to LinEMSO problems.Comment: Accepted at WADS 201

Nonlocal Modulation of Entangled Photons

We consider ramifications of the use of high speed light modulators to questions of correlation and measurement of time-energy entangled photons. Using phase modulators, we find that temporal modulation of one photon of an entangled pair, as measured by correlation in the frequency domain, may be negated or enhanced by modulation of the second photon. Using amplitude modulators we describe a Fourier technique for measurement of biphoton wave functions with slow detectors

A verified equivalent-circuit model for slotwaveguide modulators

We formulate and experimentally validate an equivalent-circuit model based on distributed elements to describe the electric and electro-optic (EO) properties of travellingwave silicon-organic hybrid (SOH) slot-waveguide modulators. The model allows to reliably predict the small-signal EO frequency response of the modulators exploiting purely electrical measurements of the frequency-dependent RF transmission characteristics. We experimentally verify the validity of our model, and we formulate design guidelines for an optimum trade-off between optical loss due to free-carrier absorption (FCA), electro-optic bandwidth, and {\pi}-voltage of SOH slot-waveguide modulators

Nanomechanical optical devices fabricated with aligned wafer bonding

This paper reports on a new method for making some types of integrated optical nanomechanical devices. Intensity modulators as well as phase modulators were fabricated using several silicon micromachining techniques, including chemical mechanical polishing and aligned wafer bonding. This new method enables batch fabrication of the nanomechanical optical devices, and enhances their performance

Distortion in linearized electrooptic modulators

Intermodulation and harmonic distortion are calculated for a simple fiber-optic link with a representative set of link parameters and a variety of electrooptic modulators: simple Mach-Zehnder, linearized dual and triple Mach-Zehnder, simple directional coupler (two operating points), and linearized directional coupler with one and two dc electrodes. The resulting dynamic ranges, gains, and noise figures are compared for these modulators. A new definition of dynamic range is proposed to accommodate the more complicated variation of intermodulation with input power exhibited by linearized modulators. The effects of noise bandwidth, preamplifier distortion, and errors in modulator operating conditions are described

Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains

NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability. Functional NMDA receptors require two copies of the GluN1 subunit coassembled with GluN2 (and/or GluN3) subunits into a heteromeric tetramer. A diverse array of allosteric modulators can upregulate or downregulate NMDA receptor activity. These modulators include both synthetic compounds and endogenous modulators, such as cis-unsaturated fatty acids, 24(S)-hydroxycholesterol, and various neurosteroids. To evaluate the structural requirements for the formation and allosteric modulation of NMDA receptor pores, we have replaced portions of the rat GluN1, GluN2A, and GluN2B subunits with homologous segments from the rat GluK2 kainate receptor subunit. Our results with these chimeric constructs show that the NMDA receptor transmembrane domain is sufficient to account for most pore properties, but that regulation by some allosteric modulators requires additional cytoplasmic or extracellular domains. SIGNIFICANCE STATEMENT Glutamate receptors mediate excitatory synaptic transmission by forming cation channels through the membrane that open upon glutamate binding. Although many compounds have been identified that regulate glutamate receptor activity, in most cases the detailed mechanisms that underlie modulation are poorly understood. To identify what parts of the receptor are essential for pore formation and sensitivity to allosteric modulators, we generated chimeric subunits that combined segments from NMDA and kainate receptors, subtypes with distinct pharmacological profiles. Surprisingly, our results identify separate domain requirements for allosteric potentiation of NMDA receptor pores by pregnenolone sulfate, 24(S)-hydroxycholesterol, and docosahexaenoic acid, three endogenous modulators derived from membrane constituents. Understanding where and how these compounds act on NMDA receptors should aid in designing better therapeutic agents